Models And Mechanisms To Evaluate Tissue Engineered Vascular Graft Stenosis
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Models And Mechanisms To Evaluate Tissue Engineered Vascular Graft Stenosis
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Author : Elizabeth S. Clark
language : en
Publisher:
Release Date : 2017
Models And Mechanisms To Evaluate Tissue Engineered Vascular Graft Stenosis written by Elizabeth S. Clark and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Congenital heart disease categories.
Congenital heart disease represents the most common form of birth defect and is present in up to 1% of all live births. Of particular interest to our group is the treatment of single ventricle disease, specifically hypoplastic left heart syndrome (HLHS) in which left-sided heart structures including the left ventricle, aorta, and mitral valve are malformed. We utilize tissue engineering principles to provide palliative treatment with Tissue-Engineered Vascular Grafts (TEVG) that allow for growth of the child’s own tissues. The TEVG overcomes limitations present in other composite grafts including thrombogenicity and lack of growth capacity. One limitation of our TEVG is that a small percentage of children develop critical stenosis requiring the utilization of interventional cardiovascular techniques. Developing both large and small animal models of TEVG stenosis will allow us to better understand clinical data sets as well as provide models to better characterize the development of neotissue formation and stenosis. The long-term goal of this project is to develop a second-generation composite vascular graft for use in children. The objective of this study is to elucidate the mechanism of TEVG neotissue formation in immunocompetent mice (Mus musculus) and characterize neotissue formation in a sheep (Ovis aries) model. Echocardiography, angiography, and magnetic resonance imaging are routinely used to evaluate children that have received the TEVG to treat HLHS. While angiography remains the clinical gold standard for evaluation of the lumen it only indirectly evaluates the vessel wall. Therefore, we sought to evaluate intravascular ultrasound (IVUS) to characterize neotissue formation in an in vivo ovine surgical model. IVUS demonstrated close correlation to angiographic and histologic changes. Additionally, IVUS measurement of graft lumen morphometry correlates with angiography measurements. This provides further data to support the use of IVUS in a clinical setting. Future preclinical experiments will utilize this modality as an additive approach to characterize the development of TEVG stenosis and neotissue remodeling over time, with specific regard to response to treatment with both interventional and therapeutic approaches. Previous research by our lab C57BL/6 mice has suggested that the transforming growth factor-ß (TGF-ß)/Smad2-3 pathway is involved in the development of TEVG stenosis. While the specific role of the TGF-ß pathway in the development of stenosis remains unknown, this pathway is upregulated in stenotic TEVG. To this end, this work seeks to evaluate the TGF-ß pathway in Cdh5-lineage cells in vivo in mice implanted with TEVG. A conditional genetic murine model was developed with endothelial-derived (Cdh5) loss of the TGF-ß receptors, TßRI and TßRII. Although TEVG have a low incidence of stenosis in both treated and control animals, Cdh5 TGF-ß pathway modulation results in altered neotissue formation including collagen production and polymeric degradation at early timepoints. We rationalize that by elucidating the cell(s) of origin for the neotissue and the role of TGF-ß receptor pathway will enable the development of targeted therapies in combination with TEVGs to improve clinical outcomes for children.
Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies
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Author : Laura Iop
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-23
Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies written by Laura Iop and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-23 with Medical categories.
Bioengineering And Biotechnology Approaches In Cardiovascular Regenerative Medicine Volume Ii
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Author : Jianyi Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-26
Bioengineering And Biotechnology Approaches In Cardiovascular Regenerative Medicine Volume Ii written by Jianyi Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-26 with Technology & Engineering categories.
This Research Topic is Volume II of a series. The previous volume, which has attracted over 40,000 views can be found here: Bioengineering and Biotechnology Approaches in Cardiovascular Regenerative MedicineCardiovascular diseases continue to be the leading cause of death while available clinical interventions have limited contributions to heart repair and regeneration. Cardiovascular regenerative medicine, characterized by a unique integration of biology, physical sciences, and bioengineering principles, has emerged as one of the most promising fields of translational research to regenerate the adult human heart.
Polymeric Biomaterials For Tissue Regeneration
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Author : Changyou Gao
language : en
Publisher: Springer Nature
Release Date : 2023-12-28
Polymeric Biomaterials For Tissue Regeneration written by Changyou Gao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-28 with Medical categories.
This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.
Hemodialysis Access
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Author : Sherene Shalhub
language : en
Publisher: Springer
Release Date : 2016-11-21
Hemodialysis Access written by Sherene Shalhub and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Medical categories.
This comprehensive reference on the fundamentals of hemodialysis access creation and advanced management for maintenance is designed to meet the needs of all surgeons and physicians responsible for the treatment and care of patients undergoing dialysis. The book opens by discussing every aspect of dialysis access planning, including selection of the right access for the individual patient and access strategies. Hemodialysis access techniques, from the most basic to the most complex and unconventional, are then described step by step, and guidance is provided on follow-up. Detailed attention is also devoted to the challenging management of specific complications of dialysis access surgery, including failing hemodialysis access. The book includes a wealth of informative, high-quality images and illustrations, and the authors are prominent vascular surgeons, transplant surgeons, general surgeons, nephrologists, and interventional radiologists from across the United States.
Fundamentals Of Vascular Biology
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Author : Margarethe Geiger
language : en
Publisher: Springer Nature
Release Date : 2024-11-27
Fundamentals Of Vascular Biology written by Margarethe Geiger and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-27 with Science categories.
This is a fully revised Second Edition of a well-structured textbook that offers essential knowledge on the vascular system. The reader will learn the properties, basic cellular mechanisms, and development of the different parts of the vascular system (including the heart and lung), gain knowledge on vascular and related diseases, and will be made familiar with common and most current methods and techniques applied to analyze the vascular system in patients, animal models, and ex vivo. This book is based on a Ph.D. Course for students from various scientific backgrounds given at the Medical University of Vienna, and it will be a valuable resource for Master ́s Students in vascular biology and biomedicine in general and a helpful tool for young researchers worldwide wishing to gain or refresh their knowledge in this field.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1987
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medicine categories.
Biomaterials Science
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Author : Buddy D. Ratner
language : en
Publisher: Academic Press
Release Date : 2012-12-31
Biomaterials Science written by Buddy D. Ratner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. - Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today - Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials - Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank
Nanomedicine
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Author : Ning Gu
language : en
Publisher: Springer Nature
Release Date : 2023-01-07
Nanomedicine written by Ning Gu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-07 with Technology & Engineering categories.
This handbook volume is part of the Reference Series: Micro/Nano Technologies. This individual volume provides a comprehensive, self-contained, and authoritative knowledge in nanomedicine. It covers the theoretical and practical aspects of functionalizations of nanoparticles as nanomedicine, including surface activation, characterization, and microemulsion systems. As a Springer Major Reference Work it is continuously updated online, allowing newcomers and other readers to keep in touch with the most up-to-date information. The book is particularly recommended to undergraduates, postgraduates, researchers, scientists, and field experts. It will inspire innovations in the highly interdisciplinary field of nanomedicine.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1994
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.