Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies
DOWNLOAD
Download Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies
DOWNLOAD
Author : Laura Iop
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-23
Vascular And Valvular Tissue Engineering Treating And Modeling Vasculopathies And Valvulopathies written by Laura Iop and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-23 with Medical categories.
Index Medicus
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2001-04
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-04 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Models And Mechanisms To Evaluate Tissue Engineered Vascular Graft Stenosis
DOWNLOAD
Author : Elizabeth S. Clark
language : en
Publisher:
Release Date : 2017
Models And Mechanisms To Evaluate Tissue Engineered Vascular Graft Stenosis written by Elizabeth S. Clark and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Congenital heart disease categories.
Congenital heart disease represents the most common form of birth defect and is present in up to 1% of all live births. Of particular interest to our group is the treatment of single ventricle disease, specifically hypoplastic left heart syndrome (HLHS) in which left-sided heart structures including the left ventricle, aorta, and mitral valve are malformed. We utilize tissue engineering principles to provide palliative treatment with Tissue-Engineered Vascular Grafts (TEVG) that allow for growth of the child’s own tissues. The TEVG overcomes limitations present in other composite grafts including thrombogenicity and lack of growth capacity. One limitation of our TEVG is that a small percentage of children develop critical stenosis requiring the utilization of interventional cardiovascular techniques. Developing both large and small animal models of TEVG stenosis will allow us to better understand clinical data sets as well as provide models to better characterize the development of neotissue formation and stenosis. The long-term goal of this project is to develop a second-generation composite vascular graft for use in children. The objective of this study is to elucidate the mechanism of TEVG neotissue formation in immunocompetent mice (Mus musculus) and characterize neotissue formation in a sheep (Ovis aries) model. Echocardiography, angiography, and magnetic resonance imaging are routinely used to evaluate children that have received the TEVG to treat HLHS. While angiography remains the clinical gold standard for evaluation of the lumen it only indirectly evaluates the vessel wall. Therefore, we sought to evaluate intravascular ultrasound (IVUS) to characterize neotissue formation in an in vivo ovine surgical model. IVUS demonstrated close correlation to angiographic and histologic changes. Additionally, IVUS measurement of graft lumen morphometry correlates with angiography measurements. This provides further data to support the use of IVUS in a clinical setting. Future preclinical experiments will utilize this modality as an additive approach to characterize the development of TEVG stenosis and neotissue remodeling over time, with specific regard to response to treatment with both interventional and therapeutic approaches. Previous research by our lab C57BL/6 mice has suggested that the transforming growth factor-ß (TGF-ß)/Smad2-3 pathway is involved in the development of TEVG stenosis. While the specific role of the TGF-ß pathway in the development of stenosis remains unknown, this pathway is upregulated in stenotic TEVG. To this end, this work seeks to evaluate the TGF-ß pathway in Cdh5-lineage cells in vivo in mice implanted with TEVG. A conditional genetic murine model was developed with endothelial-derived (Cdh5) loss of the TGF-ß receptors, TßRI and TßRII. Although TEVG have a low incidence of stenosis in both treated and control animals, Cdh5 TGF-ß pathway modulation results in altered neotissue formation including collagen production and polymeric degradation at early timepoints. We rationalize that by elucidating the cell(s) of origin for the neotissue and the role of TGF-ß receptor pathway will enable the development of targeted therapies in combination with TEVGs to improve clinical outcomes for children.
Advances In Heart Valve Biomechanics
DOWNLOAD
Author : Michael S. Sacks
language : en
Publisher: Springer
Release Date : 2019-04-08
Advances In Heart Valve Biomechanics written by Michael S. Sacks and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-08 with Science categories.
This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.
Principles Of Heart Valve Engineering
DOWNLOAD
Author : Arash Kheradvar
language : en
Publisher: Academic Press
Release Date : 2019-08-28
Principles Of Heart Valve Engineering written by Arash Kheradvar and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-28 with Science categories.
Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts. - Covers the depth and breadth of this interdisciplinary area of research - Encompasses a wide range of topics, from basic science, to the translational applications of heart valve engineering - Contains contributions from leading experts in the field that are heavily illustrated
Molecular Cellular And Tissue Engineering Of The Vascular System
DOWNLOAD
Author : Bingmei M. Fu
language : en
Publisher: Springer
Release Date : 2018-10-12
Molecular Cellular And Tissue Engineering Of The Vascular System written by Bingmei M. Fu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-12 with Science categories.
This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanisms of atherosclerotic plaque microcalcifications and human abdominal aortic aneurysms, experiments and modelling for red blood cell and tumor cell movement in microcirculation, transport across the blood-brain barrier and its role in Alzheimer’s disease, mathematical models for cell survival after hyperthermia, application of hypothermia in enhancing treatment for brain and spinal cord injuries, and damage of eardrums due to blast waves. This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.
Vascular Tissue Engineering
DOWNLOAD
Author : Feng Zhao
language : en
Publisher:
Release Date : 2021
Vascular Tissue Engineering written by Feng Zhao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cell biology categories.
This volume explores the latest techniques used to study the field of tissue engineered vascular grafts (TEVGs). The chapters in this book cover a wide array of topics such as deriving vascular cells from monocytes and induced pluripotent stem cells; engineering vascular grafts using various biomaterials and stem cells, stem cell-derived, or primary vascular cells; biomaterial modification by anticoagulation molecules; vascular bioengineering technologies such as 3D bioprinting; and fabrication of TEVGs with different geometry and multiphase structures. This book also features protocols for grafting and evaluation of vascular grafts in animal models, vascular imaging in animals, and the quantification of blood vessel permeability. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Vascular Tissue Engineering: Methods and Protocols is a valuable resource for biomedical engineers, cell biologists, vascular surgeons, doctors, and nurses.
Vascularization
DOWNLOAD
Author : Eric M. Brey
language : en
Publisher: CRC Press
Release Date : 2014-08-07
Vascularization written by Eric M. Brey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-07 with Medical categories.
A Complex and Growing Field The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration. Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications. This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine. Presents Areas of Substantial Clinical and Societal Impact The material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nanotechnology, drug delivery, stem cells, microfluidics, and biomaterial design that are optimized for supporting the formation of extensive vascular networks in regenerative medicine. A guide for researchers developing new methods for modulating vessel assembly, this text can also be used by senior undergraduate and graduate students taking courses focused on TERM.