Modified Nucleosides And Cancer
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Modified Nucleosides And Cancer
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Author : G. Nass
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Modified Nucleosides And Cancer written by G. Nass and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, 1981 in Freiburg, West Germany. The workshop was organized by Gisela Nass and sponsored by the Deutsche Forschungsgemeinschaft. The purpose of the workshop was to cover the varied analytical methods for quantitative and qualitative determination of modified nucleosides and their metabolism including bio synthesis, all in relation to the function of these compounds in the origin and growth of cancer cells. The potential signi ficance of measuring modified nucleosides in body fluids for tumor diagnosis in humans received particular attention. Various fields of research which have previously been segregat ed are thus unified in this volume. Emphasis was also placed on the fact that modified nucleosides are constituents of the genetic material, the desoxyribonucleic> acid, on the one hand, and of the transfer ribonucleic acids on the other hand, with the latter macromolecules participating not only in the translation of genetic information into protein, but also in many regulatory processes in all single- and multi-, cellular organisms including man.
Modified Nucleosides In Cancer And Normal Metabolism Methods And Applications
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Author :
language : en
Publisher: Elsevier
Release Date : 1990-05-02
Modified Nucleosides In Cancer And Normal Metabolism Methods And Applications written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-05-02 with Science categories.
Modified Nucleosides in Cancer and Normal Metabolism - Methods and Applications
Modified Nucleosides And Cancer
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Author : G Nass
language : en
Publisher:
Release Date : 1983-02-01
Modified Nucleosides And Cancer written by G Nass and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983-02-01 with categories.
Modified Nucleic Acids In Biology And Medicine
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Author : Stefan Jurga
language : en
Publisher: Springer
Release Date : 2016-07-29
Modified Nucleic Acids In Biology And Medicine written by Stefan Jurga and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with Medical categories.
This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.
Modified Nucleosides
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Author : Piet Herdewijn
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Modified Nucleosides written by Piet Herdewijn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Science categories.
Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.
Synthesis Of Natural Modified Nucleosides And Their Mass Spectrometric Quantification In Cells And Tissue
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Author : Daniel Globisch
language : en
Publisher: Cuvillier Verlag
Release Date : 2011-05-13
Synthesis Of Natural Modified Nucleosides And Their Mass Spectrometric Quantification In Cells And Tissue written by Daniel Globisch and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-13 with Science categories.
Analytical Methods For Major And Modified Nucleosides Hplc Gc Ms Nmr Uv And Ft Ir
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Author :
language : en
Publisher: Elsevier
Release Date : 1989-12-13
Analytical Methods For Major And Modified Nucleosides Hplc Gc Ms Nmr Uv And Ft Ir written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-12-13 with Science categories.
Analytical Methods for Major and Modified Nucleosides - HPLC, GC, MS, NMR, UV and FT-IR
Palladium Catalyzed Modification Of Nucleosides Nucleotides And Oligonucleotides
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Author : Anant R. Kapdi
language : en
Publisher: Elsevier
Release Date : 2018-06-04
Palladium Catalyzed Modification Of Nucleosides Nucleotides And Oligonucleotides written by Anant R. Kapdi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-04 with Science categories.
Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides describes the procedures and protocols related to the modification of nucleosides, nucleotides and oligonucleotides via Pd-mediated cross-coupling processes. The book highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist this development. Users will find key synthetic protocols for these reactions in this latest volume in the Latest Trends in Palladium Chemistry series. As most of the research in the field of antiviral agents has centered on the use of modified nucleosides that have exhibited promising activity, this book provides an up-to-date reference for both professionals in industry and other interested parties. Provides synthetic routes for useful nucleoside molecules, information otherwise found only through time-consuming literature searches Covers metal-mediated and metal-catalyzed cross coupling processes of nucleosides and related compounds Includes Suzuki-Miyaura, Stille and Sonogashira reactions, as well as C-H bond functionalization Highlights the growing area of nucleic acid modification and how Pd-mediated coupling reactions can assist
Modified Nucleic Acids
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Author : Kazuhiko Nakatani
language : en
Publisher: Springer
Release Date : 2016-04-04
Modified Nucleic Acids written by Kazuhiko Nakatani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-04 with Science categories.
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Primary Liver Cancer
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Author : Jianren Gu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-02
Primary Liver Cancer written by Jianren Gu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
"Primary Liver Cancer: Challenges and Perspectives" presents the recent progress in basic and clinical research in Primary Liver Cancer (PLC) in China and around the world. PLC patients in China make up more than 50% of the total patients worldwide. By contributing to the book, the leading experts in the field of liver cancer in China as well as in the US share with readers their new concepts, practices, and experiences from bench to bed, from population study to individual survey, from molecular search to clinical practice, and from early diagnosis to treatment. The book is intended for researchers in the fields of epidemiology, molecular genetics, cell biology, immunology of HCC and other cancers, and clinical oncology in primary liver cancer. Jianren Gu is a Professor of molecular oncology at the Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine and Academician of Chinese Academy of Engineering.