Molecular Analysis Of Dna Rearrangements In The Immune System
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Molecular Analysis Of Dna Rearrangements In The Immune System
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Author : Rolf Jessberger
language : en
Publisher: Springer
Release Date : 2012-05-21
Molecular Analysis Of Dna Rearrangements In The Immune System written by Rolf Jessberger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-21 with Medical categories.
The vertebrate immune system is distinctive among defense systems of multicellular organisms. In addition to nonspecific immunity, it generates a randomized array of millions of antigen receptors (immunoglobulins and T-cell receptors). A subset of these receptors are critical for binding to invading microbes or biochemicals from them to tag the microbes for elimination. Three site-directed DNA modification processes are critical to this process in vertebrates. V(D)J recombination generates the array of exons that encode the antigen binding pockets. Recent work summarized in this volume describes the dissection of this process at the biochemical level. The mechanism of the reaction is now understood in considerable detail. The proteins that catalyze many steps of the process have now been identified by biochemical and genetic recon stitution and by analysis of genetic mutants defective in V(D)J recombination. Class switch recombination is the process by which the variable domain exon of the heavy chain is changed from IgM to IgG, IgA. or IgE. Recent progress is described in the de velopment of an extrachromosomal substrate assay system. Molecular genetic analysis of the process in transgenics is defining some of the cis sequence requirements. Biochemical assays for defining enzymatic components are also described. In addition to exciting progress in V(D)J recombination and class switch recombination, one chapter describes recent pro gress in somatic hypermutation.
Biomedical Index To Phs Supported Research Pt A Subject Access A H
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Author :
language : en
Publisher:
Release Date : 1994
Biomedical Index To Phs Supported Research Pt A Subject Access A H written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.
Structural Approaches To Sequence Evolution
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Author : Ugo Bastolla
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-26
Structural Approaches To Sequence Evolution written by Ugo Bastolla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-26 with Science categories.
Recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1990
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medicine categories.
Nucleic Acids Abstracts
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Author :
language : en
Publisher:
Release Date : 1997
Nucleic Acids Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Nucleic acids categories.
Genetic Instability And Tumorigenesis
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Author : Michael B. Kastan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Genetic Instability And Tumorigenesis written by Michael B. Kastan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is "how do these genetic changes occur in somatic cells?". Epidemiologic data suggest that exposure to environmental carcinogens con tributes to the genesis of at least 80% of all human cancers (DOLL and PETO 1981). Thus, it is natural to suspect that the genetic changes in somatic cells which con tribute to the transformed phenotype arise from DNA damage caused by such exposures. Therefore, understanding how cells respond to DNA-damaging agents is likely to be an important component of our understanding of the genesis of human tumors.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1989
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.
Essentials Of Anatomic Pathology
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Author : Liang Cheng
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-02-14
Essentials Of Anatomic Pathology written by Liang Cheng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-14 with Medical categories.
A distinguished panel of experts concisely interprets recent diagnostic advances in classic pathology to produce a readily accessible guide that helps the practicing pathologist achieve accurate everyday diagnoses. Arranging the important diagnostic features of the most common diseases and tumors by organ systems, this book provides for each disease the pertinent clinical information, its salient diagnostic features, relevant ancillary data (e.g., immunohistochemical profiles), the main differential diagnoses, and the latest tumor staging information, thus ensuring easy access to all the information essential for case sign-out. Authoritative and richly detailed, Essentials of Anatomic Pathology concisely summarizes all the critical information every pathologist needs today to recognize, understand, and accurately interpret both gross and light microscopic findings in anatomic pathology specimens.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1986
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medicine categories.
Adeno Associated Virus Aav Vectors In Gene Therapy
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Author : Kenneth I. Berns
language : en
Publisher: Springer
Release Date : 1996-08-01
Adeno Associated Virus Aav Vectors In Gene Therapy written by Kenneth I. Berns and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-01 with Medical categories.
Human gene therapy holds great promise for the cure of many genetic diseases. In order to achieve such a cure there are two requirements. First, the affected gene must be cloned, its se quence determined and its regulation adequately characterized. Second, a suitable vector for the delivery of a good copy of the affected gene must be available. For a vector to be of use several attributes are highly desirable: these include ability to carry the intact gene (although this may be either the genomic or the cDNA form) in a stable form, ability to introduce the gene into the desired cell type, ability to express the introduced gene in an appropriately regulated manner for an extended period of time, and a lack of toxicity for the recipient. Also of concern is the frequency of cell transformation and, in some cases, the ability to introduce the gene into nondividing stem cells. Sev eral animal viruses have been tested as potential vectors, but none has proven to have all the desired properties described above. For example, retroviruses are difficult to propagate in sufficient titers, do not integrate into nondividing cells, and are of concern because of their oncogenic properties in some hosts and because they integrate at many sites in the genome and, thus, are potentially insertional mutagens. Additionally, genes introduced by retroviral vectors are frequently expressed for relatively short periods of time. A second virus used as a vector in model systems has been adenovirus (Ad).