Molecular And Cellular Crosstalk On Neuronal Functionality And Regulation From Development To Pathology
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Molecular And Cellular Crosstalk On Neuronal Functionality And Regulation From Development To Pathology
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Author : Inmaculada Segura
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-27
Molecular And Cellular Crosstalk On Neuronal Functionality And Regulation From Development To Pathology written by Inmaculada Segura and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-27 with Science categories.
Transcription Factors In The Nervous System
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Author : Gerald Thiel
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-12
Transcription Factors In The Nervous System written by Gerald Thiel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Science categories.
This first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases. With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, neurochemists and molecular biologists.
Crosstalk Between Microrna And Oxidative Stress In Physiology And Pathology
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Author : Antonella Fioravanti
language : en
Publisher: MDPI
Release Date : 2020-06-18
Crosstalk Between Microrna And Oxidative Stress In Physiology And Pathology written by Antonella Fioravanti and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-18 with Science categories.
MicroRNAs (miRNAs) are small noncoding RNAs that are 19–24 nucleotides in length, following maturation. Recent evidence has demonstrated their key role as post-transcriptional regulators of gene expression through the binding of specific sequences within target messenger RNA (mRNA). miRNAs are involved in the synthesis of a very large number of proteins, and it is speculated that they could regulate up to 30% of the human genome. They control virtually every cellular process and are essential for animal development, cell differentiation, and homeostasis. Altered miRNA expression has been linked to such pathological events as inflammatory, degenerative, or autoimmune processes and have been associated with several diseases, including cancer, cardiovascular diseases, diabetes mellitus, and rheumatic and neurological disorders. Recently, miRNAs have been found in many different biological fluids, and this observation suggests the potential of miRNAs as new candidate biomarkers for diagnosis, classification, prognosis, and responsiveness in the treatment of different pathological conditions. Furthermore, the development of therapeutic strategies that involve either restoring or repressing miRNAs expression and activity has attracted much attention. Significant progress has been made in the systems for delivery of miRNAs, even if substantial improvements in this area are still necessary. Although they have been extensively studied, a number of interesting questions regarding the physiological and pathological role of miRNAs have been postulated, and their potential diagnostic and therapeutic role remain yet unanswered. Reactive oxygen species (ROS) are free radical-containing oxygen molecules derived from cellular oxidative metabolism, including enzyme activities and mitochondrial respiration, and play a pivotal role in many cellular functions. Whereas ROS are essential for normal cellular processes, their aberrant production, or failure of the capacity to scavenge excessive ROS, induces an altered redox status with excessive synthesis of free radicals, leading to an imbalance in the redox environment of the cell. The loss of normal ROS levels causes lipid, protein, and DNA damage, which contribute to the development of various pathologies including neurological disorders, rheumatic and cardiovascular diseases, diabetes, and cancer. Increasing evidence highlights that there is crosstalk between miRNAs and components of redox signaling, even if this complex and the characteristics of mutual interaction need to be amply elucidated. Hence, both miRNAs and oxidative stress are involved in the multifactorial development and progression of acute and chronic diseases by influencing numerous signaling and metabolic pathways. The Special Issue entitled "Crosstalk between MicroRNA and Oxidative Stress in Physiology and Pathology" of the International Journal of Molecular Sciences includes original articles and reviews that provide new insights into the interaction between miRNAs and oxidative stress under normal and pathological conditions which can assist in the development of new therapeutic strategies. Finally, I would like to thank all the authors for their excellent contribution. I hope this Special Issue will provide readers with updated knowledge about the role of miRNAs and oxidative stress in physiology and pathology.
Emerging Mechanisms In Neuronal Signaling From Cell Biology To Pathogenesis
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Author : Mario Eduardo Guido
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-12
Emerging Mechanisms In Neuronal Signaling From Cell Biology To Pathogenesis written by Mario Eduardo Guido and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Molecular Mechanisms Of Glia In Development And Disease
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Author : Ryan B. MacDonald
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-11
Molecular Mechanisms Of Glia In Development And Disease written by Ryan B. MacDonald and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-11 with Science categories.
Modeling Neuromuscular Diseases To Determine Molecular Drivers Of Pathology And For Drug Discovery
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Author : David Lee Mack
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-14
Modeling Neuromuscular Diseases To Determine Molecular Drivers Of Pathology And For Drug Discovery written by David Lee Mack and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-14 with Science categories.
72nd Annual Meeting Of The Italian Society Of Physiology New Perspectives In Physiological Research
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Author : Giovanna Valenti
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-15
72nd Annual Meeting Of The Italian Society Of Physiology New Perspectives In Physiological Research written by Giovanna Valenti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.
The 72nd Meeting of the Italian Society of Physiology (SIF) gathers scientists from universities and institutes across Europe and offers a platform for discussing the most exciting developments in the areas of basic and translational physiology. This Frontiers Research Topic will collect varied contributions from original research to review articles from SIF participants covering key achievements and latest advancements in the field of physiology. This collection is led by Guest Editors Prof. Giovanna Valenti, Prof. Andrea Gerbino and Prof. Grazia Tamma from Università degli Studi di Bari Aldo Moro and Prof. Fiorenzo Conti from Università Politecnica delle Marche, Ancona, Italy.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1995
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medicine categories.
Crosstalk Between Microrna And Oxidative Stress In Physiology And Pathology
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Author : Antonella Fioravanti
language : en
Publisher:
Release Date : 2020
Crosstalk Between Microrna And Oxidative Stress In Physiology And Pathology written by Antonella Fioravanti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
MicroRNAs (miRNAs) are sm ...
Transcription Regulation Brain Development And Homeostasis A Finely Tuned And Orchestrated Scenario In Physiology And Pathology
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Author : Estela Maris Muñoz
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-21
Transcription Regulation Brain Development And Homeostasis A Finely Tuned And Orchestrated Scenario In Physiology And Pathology written by Estela Maris Muñoz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-21 with Science categories.