Home eBooks Download › molecular and cellular mechanisms of mutagenesis

Molecular And Cellular Mechanisms Of Mutagenesis

Download Molecular And Cellular Mechanisms Of Mutagenesis PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Molecular And Cellular Mechanisms Of Mutagenesis book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Molecular And Cellular Mechanisms Of Mutagenesis

DOWNLOAD

Author : J. Lemontt
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Molecular And Cellular Mechanisms Of Mutagenesis written by J. Lemontt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

It has been nearly 35 years since the peacetime Biology Division of Oak Ridge National Laboratory was started, born of rather inauspicious conditions. Virtually no facilities were available and most of the wartime scientists had left. So, when we started out, it was obvious to me that something had to be done to reestab lish research. Even more, because Oak Ridge was not known at that time for its biological work but rather for the separation of Uranium 235, nuclear reactor development, and radioisotope produc tion, a new tradition had to be promoted. Although good biological work had been done at Oak Ridge during the war to protect the workers and the results of this work were quite excellent, very few installations remained. When we started the work of the Biology Division, it became essential to make it part of the flow of mod~rn biology allover the world. As Director, I had to do more than just attract promising scientists. We created an atmosphere conducive to creative research and nurtured all of the other aspects of a productive laboratory. Of course, we carefully prepared the results of our work in publish able form. We made a sincere effort to invite seminar speakers and lecturers to come to Oak Ridge despite the sacrifices this presented to our early budget. We also had to do something more, and here I "cashed in" on my experience of the previous 15 years.

Molecular And Cellular Mechanisms Of Toxicity

DOWNLOAD

Author : Lewis L. Smith
language : en
Publisher: CRC Press
Release Date : 2019-06-04

Molecular And Cellular Mechanisms Of Toxicity written by Lewis L. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.

First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.

Molecular And Cellular Mechanisms Of Toxicity

DOWNLOAD

Author : Taylor & Francis Group
language : en
Publisher: CRC Press
Release Date : 2020-12-12

Molecular And Cellular Mechanisms Of Toxicity written by Taylor & Francis Group and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-12 with categories.

Induced Mutagenesis

DOWNLOAD

Author : Christopher W. Lawrence
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Induced Mutagenesis written by Christopher W. Lawrence and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, and the relative merits of different tests are currently under debate. Although such tests are of great value, and are indeed indispensable, they are not, nevertheless, sufficient. In the long term, accurate estimation of hazard will also require a better understanding of the various mechanisms of mutagenesis, and in many instances these remain remarkably elusive. Our knowledge and appreciation of the problem has increased substantially over the last few years, but the precise way in which many mutagens cause mutations is not yet known. The aims of this conference were therefore two-fold. The first was to survey present information about mutagenic mechanisms, drawing together data from work with various experimental approaches and organisms, in order to discern the principles governing the action of different mutagens. The second was to examine the implications of such principles for the execution and evaluation of test procedures, and critically assess the research areas that need further attention in order to improve the interpretation of test results. Chris Lawrence v ACKNOWLEDGEMENT We gratefully acknowledge the support provided for this Conference by the U.,S. Department of Energy, The Foundation for Microbiology, Exxon Corporation and the University of Rochester.

Dna Repair Mechanisms

DOWNLOAD

Author : Philip Hanawalt
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Dna Repair Mechanisms written by Philip Hanawalt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.

DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are grouped with the related workshop and poster manuscripts. The first two parts generally tackle repair in terms of its identification and quantification, as well as the models, systems, and perspectives it utilizes. The following parts discuss the various types of repair including base excision, nucleotide excision repair in bacteria, excision repair in mammalian cells, inducible/error-prone repair in prokaryotes, and strand break repair in mammalian cells among others. This reference material looks into the replicative bypass mechanisms in mammalian cells, viral probes, and hereditary repair defects. It explains repair deficiency and human disease, as well as mutagenesis and carcinogenesis. The last part of this book deals with the consequences and effects of DNA repair. This volume is a helpful source of reference for students, teachers, scientists, and researchers in the different fields of genetics, radiology, biochemistry, and environmental biology.

Molecular Biology Of The Cell

DOWNLOAD

Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.

Molecular And Biochemical Toxicology

DOWNLOAD

Author : Robert C. Smart
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-05

Molecular And Biochemical Toxicology written by Robert C. Smart and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-05 with Science categories.

An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.

Mechanisms Of Environmental Mutagenesis Carcinogenesis

DOWNLOAD

Author : A. Kappas
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mechanisms Of Environmental Mutagenesis Carcinogenesis written by A. Kappas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

The 19th annual meeting of the European Environmental Mutagen Society was held in Rhodes, Greece, from October 21st to 26th, 1989. The programme was chosen to explore what is currently known about the mechanisms of mutagenesis and carcinogenesis, induced by environmental agents, and the questions regarding the relationship of these two processes. Recent findings, techniques and methodologies in the area of biomonitoring of humans exposed to environmental mutagens-carcinogens were presented and considerable attention was also paid to the aspects and issues of collaborative environmental policy. Researchers from allover the world contributed to the programme of the meeting with posters and oral presentations, providing a variety of new data and interesting scientific approaches. A number of outstanding scientists were invited to present the results of their work. It is only their presenta tions which are included in this book, covering the following topics: Mutations and carcinogenesis; mechanisms of chemical ly-induced genetic effects on molecular, chromosomal and cell division level; adaptability and repair mechanisms; chemical carcinogenesis and oncogenes; structure and metabolism of mutagens-carcinogens; biomonitoring and epidemiology of humans exposed to environmental mutagens-carcinogens. For the sake of evaluating and controlling the mutagenic and carcinogenic potential of our environment it is indispens able to understand the mechanisms and processes by which chemicals act on the genetic material, causing either heredi tary disease or cancer. The pUblication of these proceedings will hopefully contribute to this task.

Molecular Mechanisms Of Mutation In S Cerevisiae

DOWNLOAD

Author : Ewa Teresa Lis
language : en
Publisher: ProQuest
Release Date : 2008

Molecular Mechanisms Of Mutation In S Cerevisiae written by Ewa Teresa Lis and has been published by ProQuest this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Mutagenesis categories.

The transmission of genetic information from parent to daughter cells is a fundamental process essential to all life. Cells have evolved multiple mechanisms to protect the fidelity of genetic information. However, perfect DNA replication and repair is not desired as it would prevent evolution and generation of diversity. Thus cells also have mechanisms to introduce mutations into the genome. Using high-throughput genomic approaches, we isolated genes involved both in DNA damage repair as well as in mutagenesis. Characterization of DOA1, a gene isolated from the DNA damage repair screen, improved our understanding of ubiquitin homeostasis under DNA damage conditions. Specifically we showed that ubiquitin trimers were broken down to monoubiquitin, in a Doa1-dependent manner, and channeled into DNA damage tolerance pathways as well as to facilitate histone H2B ubiquitination. The mutagenesis screen isolated RNR4, a component of ribonucleotide reductase, a key enzyme involved in dNTP synthesis. Surprisingly we showed that rather than facilitating lesion bypass by the conventional TLS polymerases, the upregulation of dNTP levels following DNA damage allowed a replicative polymerase, Pol[delta to bypass lesions. Remarkably, we also showed that this novel mutation pathway can be efficiently inhibited with a small molecule. Moreover, the mutagenesis screen also isolated genes involved in the maintenance of ploidy. Most genes encoded components of chromatin remodeling showing just how important chromatin modification is to the faithful transmission of genetic information. Lastly, we also improved the conventional methods of measuring mutation and showed that the contribution of REV3 to mutation may be overestimated. In all, these studies have improved our understanding of how cells mutate and allowed us to begin to inhibit these processes as a therapeutic strategy.

Molecular And Environmental Aspects Of Mutagenesis

DOWNLOAD

Author : Louise Prakash
language : en
Publisher: Charles C. Thomas Publisher
Release Date : 1974

Molecular And Environmental Aspects Of Mutagenesis written by Louise Prakash and has been published by Charles C. Thomas Publisher this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Science categories.

Molecular And Cellular Mechanisms Of Mutagenesis

Recent Posts