Molecular And Functional Models In Neuropsychiatry
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Molecular And Functional Models In Neuropsychiatry
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Author : Jim J. Hagan
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-02
Molecular And Functional Models In Neuropsychiatry written by Jim J. Hagan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-02 with Medical categories.
The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.
Synaptic Stress And Pathogenesis Of Neuropsychiatric Disorders
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Author : Maurizio Popoli
language : en
Publisher: Springer
Release Date : 2014-07-28
Synaptic Stress And Pathogenesis Of Neuropsychiatric Disorders written by Maurizio Popoli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-28 with Medical categories.
Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.
Molecular Biology Of Neuropsychiatric Disorders
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Author : Dieter B. Wildenauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-28
Molecular Biology Of Neuropsychiatric Disorders written by Dieter B. Wildenauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-28 with Science categories.
It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.
Genomics Circuits And Pathways In Clinical Neuropsychiatry
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Author : Thomas Lehner
language : en
Publisher: Academic Press
Release Date : 2016-06-07
Genomics Circuits And Pathways In Clinical Neuropsychiatry written by Thomas Lehner and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-07 with Science categories.
This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment
Neurobiology Of Mental Illness
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Author : Dennis S. Charney
language : en
Publisher: Oxford University Press
Release Date : 2005-07-21
Neurobiology Of Mental Illness written by Dennis S. Charney and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-21 with Medical categories.
The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.
Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders
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Author : XIAO-HONG LU
language : en
Publisher: Academic Press
Release Date : 2009-11-06
Novel Approaches To Studying Basal Ganglia And Related Neuropsychiatric Disorders written by XIAO-HONG LU and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-06 with Science categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering Novel Approaches to Studying Basal Ganglia and Related Neuropsychiatric Disorders. Topics covered include molecular profiling of direct and indirect striatal medium spiny neurons, the role of epigenetics in development and function of basal ganglia and transgenic animal models for Parkinson's disease.
The Handbook Of Neuropsychiatric Biomarkers Endophenotypes And Genes
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Author : Michael Ritsner
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-21
The Handbook Of Neuropsychiatric Biomarkers Endophenotypes And Genes written by Michael Ritsner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-21 with Medical categories.
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
The Handbook Of Neuropsychiatric Biomarkers Endophenotypes And Genes
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Author : Michael S. Ritsner
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-24
The Handbook Of Neuropsychiatric Biomarkers Endophenotypes And Genes written by Michael S. Ritsner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-24 with Medical categories.
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
Understanding Neuropsychiatric Disorders
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Author : Martha E. Shenton
language : en
Publisher: Cambridge University Press
Release Date : 2010-12-09
Understanding Neuropsychiatric Disorders written by Martha E. Shenton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-09 with Medical categories.
An informative and comprehensive review from the leading researchers in the field, this book provides a complete one-stop guide to neuroimaging techniques and their application to a wide range of neuropsychiatric disorders. For each disorder or group of disorders, separate chapters review the most up-to-date findings from structural imaging, functional imaging and/or molecular imaging. Each section ends with an overview from a internationally-renowned luminary in the field, addressing the question of 'What do we know and where are we going?' Richly illustrated throughout, each chapter includes a 'summary box', providing readers with explicit take-home messages. This is an essential resource for clinicians, researchers and trainees who want to learn how neuroimaging tools lead to new discoveries about brain and behaviour associations in neuropsychiatric disorders.
Charney Nestler S Neurobiology Of Mental Illness
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Author : Dennis S. Charney
language : en
Publisher: Oxford University Press
Release Date : 2018
Charney Nestler S Neurobiology Of Mental Illness written by Dennis S. Charney and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Medical categories.
Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.