Molecular Basis For Genetic Instability In Werner Syndrome
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Molecular Basis For Genetic Instability In Werner Syndrome
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Author : Polly Rodgers Prince
language : en
Publisher:
Release Date : 1999
Molecular Basis For Genetic Instability In Werner Syndrome written by Polly Rodgers Prince and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Genome And Disease
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Author : Jean-Nicolas Volff
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2006-01-01
Genome And Disease written by Jean-Nicolas Volff and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-01 with Medical categories.
Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important 'caretaker' genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.
Chromosomal Instability And Aging
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Author : Fuki Hisama
language : en
Publisher: CRC Press
Release Date : 2003-01-29
Chromosomal Instability And Aging written by Fuki Hisama and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-29 with Medical categories.
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. The authors provide in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of aging processes and age-related diseases, including cancer development. Chromosomal Instability and Aging describes cloning genes for human chromosomal instability disorders, the causal factors and consequences of chromosomal injury, the telomere hypothesis of aging, and age-dependant mitochondrial genetic instability. It includes more than 2200 references to facilitate further research, making it an informative and timely guide.
The Genetic Basis Of Human Cancer
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Author : Kenneth W. Kinzler
language : en
Publisher: McGraw-Hill Professional Publishing
Release Date : 2002
The Genetic Basis Of Human Cancer written by Kenneth W. Kinzler and has been published by McGraw-Hill Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Health & Fitness categories.
-- Current coverage of diagnosis and treatment on a wide spectrum of active cancer research.
Handbook Of Models For Human Aging
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Author : P. Michael Conn
language : en
Publisher: Elsevier
Release Date : 2011-04-28
Handbook Of Models For Human Aging written by P. Michael Conn and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations
Molecular Mechanisms Of Werner S Syndrome
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Author : Michel Lebel
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-09-14
Molecular Mechanisms Of Werner S Syndrome written by Michel Lebel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-14 with Medical categories.
During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a great deal of information that gives some aspects of aging a better understanding. This book explores Werner's syndrome. To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.
Genes And Obesity
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-12-17
Genes And Obesity written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-17 with Science categories.
A number of genes have been identified that are associated with an increased body mass index (BMI), the standard measurement of obesity. By analyzing these genes, researchers hope to gain a better understanding of what causes obesity and develop ways to tackle the problem. The study of genes and obesity could lead to new treatments. Genes and Obesity reviews the latest developments in the field. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Helicases From All Domains Of Life
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Author : Renu Tuteja
language : en
Publisher: Academic Press
Release Date : 2018-10-15
Helicases From All Domains Of Life written by Renu Tuteja and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-15 with Science categories.
Helicases are ubiquitous enzymes found throughout evolution. Research in the helicase field has been going on for a long time now but in recent past with the completion of so many genomes, these enzymes have been discovered in a number of organisms. But the available literature is scattered. The huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make difficult for the interested scholar to grasp a comprehensive view of the field. Helicases from all Domains of Life is the first book to compile information about helicases from many different organisms in one place. Knowledge of the functions and features of helicases across the different kingdoms of life are a valuable source of novel ideas and information The book begins with a chapter on the evolutionary history of helicases followed by three "overview" chapters: one for bacteria/archaea (which are not mentioned), one for plants/algae and one for human helicases The overview chapters are followed by specific chapters on selected helicases of great importance from a biological/applicative point of view
Genome Stability And Human Diseases
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Author : Heinz-Peter Nasheuer
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-11
Genome Stability And Human Diseases written by Heinz-Peter Nasheuer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-11 with Medical categories.
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
Werner S Syndrome And Human Aging
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Author : Darrell Salk
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Werner S Syndrome And Human Aging written by Darrell Salk and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Medical categories.