Molecular Biology Of Endometrial Carcinoma
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Cell And Molecular Biology Of Endometrial Carcinoma
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Author : H. Kuramoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell And Molecular Biology Of Endometrial Carcinoma written by H. Kuramoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting the latest work in the cell and molecular biology of endometrial carcinoma, this volume is a valuable resource for gynecologists, pathologists, and molecular biologists.
Molecular Biology Of Endometrial Carcinoma
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Author : Ivana Marková
language : en
Publisher:
Release Date : 2012
Molecular Biology Of Endometrial Carcinoma written by Ivana Marková and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medicine categories.
Molecular Biology of Endometrial Carcinoma.
Molecular Genetics Of Endometrial Carcinoma
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Author : Lora Hedrick Ellenson
language : en
Publisher: Springer
Release Date : 2016-12-01
Molecular Genetics Of Endometrial Carcinoma written by Lora Hedrick Ellenson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-01 with Medical categories.
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Precision Molecular Pathology Of Uterine Cancer
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Author : Michael T. Deavers
language : en
Publisher: Springer
Release Date : 2017-10-28
Precision Molecular Pathology Of Uterine Cancer written by Michael T. Deavers and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-28 with Medical categories.
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Molecular Biology And Prevention Of Endometrial Cancer
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Author :
language : en
Publisher:
Release Date : 2003
Molecular Biology And Prevention Of Endometrial Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
To increase our understanding of the molecular aberrations associated with endometrial carcinogenesis and the biologic mechanisms underlying the protective effect of oral contraceptive therapy. Methods: 1) Oligonucleotide microarray analysis was performed on a panel of endometrial cancers. 2) A subset of adenocarcinoma cases from the International DES Registry was analyzed for MSI and the poor quality of the DNA from many of these cases prohibited an adequate analysis of the entire set. The cases are currently being evaluated for PTEN expression. 3) We are in the process of analyzing the endometrium from cymologous macaques that were exposed to long term progestins as part of the three year randomized controlled trial. 4) A clinical trial comparing progestin versus placebo is underway that will facilitate investigation of the effects of progestin exposure on the endometrial lining Results: 1) Different histological types of endometrial cancer have unique genomic expression patterns. 2) Endometrioid endometrial cancers with microsatellite instability have a genomic expression pattern that is different from those microsatellite stability.
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Author :
language : en
Publisher:
Release Date : 2001
written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Biology Of Female Cancers
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Author : Simon P. Langdon
language : en
Publisher: CRC Press
Release Date : 1997-03-18
Biology Of Female Cancers written by Simon P. Langdon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-03-18 with Medical categories.
Biology of Female Cancers explores what can be learned about female cancers by summarizing what is known about the mechanisms of growth regulation and genetic features associated with common forms of female cancers, including malignancies of the breast, ovary, uterus, cervix, vulva, and gestational trophoblastic disease. The book describes the etiology, incidence, pathology, staging, and treatment of each type of cancer. The risk of developing particular tumor types and how their growth may be influenced by hormones, growth factors, and cytokines is also discussed. For oncologists, gynecologists and obstetricians, cell biologists, and everyone interested in learning more about female cancers, the Biology of Female Cancers offers a comprehensive, unique approach.
Molecular Diagnosis And Targeting For Gynecologic Malignancy
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Author : Seiji Isonishi
language : en
Publisher: Springer Nature
Release Date : 2021-03-05
Molecular Diagnosis And Targeting For Gynecologic Malignancy written by Seiji Isonishi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-05 with Medical categories.
This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.
Molecular Research Of Endometrial Pathophysiology
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Author : Paola Viganò
language : en
Publisher: MDPI
Release Date : 2019-10-14
Molecular Research Of Endometrial Pathophysiology written by Paola Viganò and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-14 with Social Science categories.
The endometrium has been the subject of intense research in a variety of clinical settings, because of its importance in the reproductive process and its role in women’s health. In the past 15 years, significant efforts have been invested in defining the molecular phenotype of the receptive phase endometrium as well as of various endometrial pathologies. Although this has generated a wealth of information on the molecular landscape of human endometrium, there is a need to complement this information in light of the novel methodologies and innovative technical approaches. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms of endometrium and endometrium-related disorders. The progress made in the molecular actions of steroids, in the metabolism of steroids and intracrinology, in endometrial intracellular pathways, in stem cells biology, as well as in the molecular alterations underlying endometrium-related pathologies has been the focus of the reviews and papers included.]
Uterine Cancer
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Author : Franco Muggia
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-10
Uterine Cancer written by Franco Muggia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-10 with Medical categories.
For the Editors, the task of writing a Preface is most satisfying. It represents the completion of the book and a moment of reflection on whether the whole is more than the sum of all the parts. And also, one must reflect on how this book is likely to be utilized in this era of rapid communications. The Editors first met in May 2003 at a stimulating Italian symposium on endometrial cancer (organizers Drs. Luigi Frigerio, Roberto Grassi and Andrea Lissoni, with participation of the deans of Italian Gynecologic Oncology, Ugo Bianchi and Constantino Mangioni) that took place at Bergamo and Caravaggio. The impressive gains in biology and clinical trials were further discussed by the two editors and others that are co-authors in this venture on this side of the Atlantic at a 2004 Educational Session at the American Society of Clinical Oncology (ASCO). The pace of progress in various aspects of management of uterine cancer was no- worthy, not only was tumor biology fueling novel hypotheses such as questioning the mesenchymal origin of carcinosarcomas, but knowledge of molecular pathways was beginning to be applied as prognostic and as predictive factors portending benefit from systemic therapies. Surgical staging and sensitive imaging provided the underpinning for refining our treatment algorithms. Finally, a role for che- therapy had finally become established, principally through phase III studies c- paring chemotherapy to radiation in mostly locally advanced stages III and IV that had undergone resection.