Molecular Biology Of Valvular Heart Disease
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Molecular Biology Of Valvular Heart Disease
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Author : Nalini M. Rajamannan
language : en
Publisher: Springer Science & Business
Release Date : 2014-04-28
Molecular Biology Of Valvular Heart Disease written by Nalini M. Rajamannan and has been published by Springer Science & Business this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Medical categories.
The cellular mechanisms of valvular heart disease have not been elucidated until the last decade. To date, there is no medical therapy that is FDA or CE mark approved for the treatment and/or slowing the progression of this disease. This textbook will provide the cellular basis for medical therapy. Over the past decade, research laboratories are more and more evolving into valvular biology programs from the traditional vascular biology. The science between the two disciplines, although has several similarities has unique cellular targets secondary to the embryologic derivation of the heart valve and the hemodynamics involved in the understanding of this disorders. This textbook will be a natural progression from the recently published text Cardiac Valvular Medicine, Springer 2012. This new textbook will provide the cellular details and the more basic molecular biology approaches towards understanding the disease, providing novel cellular targets and finally developing future clinical trials in the medical treatment of valvular heart disease in the future.
Mitral Valve Disease
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Author : Francis C. Wells
language : en
Publisher: Springer Nature
Release Date : 2021-04-12
Mitral Valve Disease written by Francis C. Wells and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-12 with Medical categories.
This book provides a comprehensive review of the basic science of the mitral valve needed to begin to comprehend both normal and the failing valve. This knowledge is infrequently discussed in the clinical arena, with a rush towards definition of lesions based on limited analysis. It provides a ready single source of the most important basic science subjects pertaining to the valve, and the pathologies found therein, and thus a more complete understanding of the factors that result in dysfunction may be appreciated. Mitral Valve Disease: Basic Sciences and Current Approaches to Management includes chapters on embryology and anatomy, including details of structural, comparative and functional features. Since the valve is completely influenced by genetics and molecular biology, subjects rarely if ever addressed in the clinical arena, these topics receive in-depth attention. Coverage concludes with lengthy discussions of the importance of multi-disciplinary work, along with the importance of the electrophysiological disturbances encountered in some groups of these patients. It therefore is an essential and up-to-date resource for the practicing and trainee cardiac surgeon and any researcher working within this topic.
Advances In Heart Valve Biomechanics
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Author : Michael S. Sacks
language : en
Publisher: Springer
Release Date : 2019-04-08
Advances In Heart Valve Biomechanics written by Michael S. Sacks and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-08 with Science categories.
This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.
Heart Failure
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Author : Arnold M. Katz
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2012-11-07
Heart Failure written by Arnold M. Katz and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-07 with Medical categories.
This Second Edition of Dr. Katz's highly acclaimed text has been thoroughly revised to incorporate the latest advances in the study and treatment of heart failure. The book explains the pathophysiology, molecular mechanisms, clinical manifestations, and therapy of heart failure in an integrated, reader-friendly manner that is accessible to both clinicians and basic scientists. More than 100 illustrations, most created for this book by the authors, complement the text. This edition has been completely reorganized. Chapters describe the hemodynamic basis for the clinical manifestations of heart failure; the neurohumoral responses in heart failure and key signaling pathways that mediate functional responses; the proliferative responses in failing hearts; the cellular and molecular abnormalities in the failing heart; the rationale for various therapeutic approaches; and the management of specific groups of patients. The chapters on therapy have been written by a noted clinician, Marvin A. Konstam.
From Biology To Clinical Management An Update On Aortic Valve Disease 2nd Edition
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Author : Cécile Oury
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-04
From Biology To Clinical Management An Update On Aortic Valve Disease 2nd Edition written by Cécile Oury and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-04 with categories.
Calcific aortic valve stenosis is the most frequent valvular heart disease in Western countries, affecting up to 13% of individuals over 75 years. The disease is associated with considerable morbidity and mortality. It is characterized by fibro-calcification of aortic valve cusps and concomitant left ventricular remodelling due to chronic pressure overload, which can evolve into overt heart failure. It progresses very slowly until the onset of symptoms, the indication for aortic valve replacement. Today, about 300,000 aortic valve replacements are performed annually worldwide, either via surgery or transcatheter implantation. This is the only treatment shown to improve survival. There is no pharmacological treatment to prevent or slow disease progression. Major risk factors include older age, congenital anomalies of the aortic valve (bicuspid valve), male gender, hypertension, dyslipidaemia, smoking, and diabetes. However, how these factors contribute to the disease in unclear. Due to the disease itself, patients are at increased risk of both thrombosis and bleeding, which, in addition to advanced age and comorbidities, makes antithrombotic management of these patients difficult. Regarding valve prostheses, the ideal prosthesis either mechanical or biological still does not exist. Clinically available prostheses can lead to major complications, thrombosis or infection, which necessitate reoperation or cause death in 50-60% of patients within 10 years post-implantation. Hence, there are major unmet medical needs in CAVS and more basic and translational research is definitely required. Our Research Topic depicts major challenges and research paths that could be followed to address these major health needs.
Cellular And Molecular Pathobiology Of Cardiovascular Disease
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Author : Monte Willis
language : en
Publisher: Academic Press
Release Date : 2013-12-23
Cellular And Molecular Pathobiology Of Cardiovascular Disease written by Monte Willis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-23 with Medical categories.
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Heart Valves
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Author : Paul A. Iaizzo
language : en
Publisher: Springer Nature
Release Date : 2023-06-08
Heart Valves written by Paul A. Iaizzo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-08 with Science categories.
This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.
Heart Development And Disease
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-04-02
Heart Development And Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-02 with Science categories.
Heart Development and Disease, Volume 156 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters including Macrophages during heart valve development, Computational models of cardiovascular biology, Mechanisms of early sarcomere assembly, Role of RNA binding proteins during heart development and disease, Early heart development and morphogenesis, PSC models for development and disease, ECM or SHF development, Role of metabolism during heart development, Cellular ploidy in cardiac biology, and Genetics of CHD in the human population. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Heart Development Disease
Pathophysiology Evaluation And Management Of Valvular Heart Diseases
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Author : Jeffrey S. Borer
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2004-01-01
Pathophysiology Evaluation And Management Of Valvular Heart Diseases written by Jeffrey S. Borer and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-01 with Medical categories.
Written by faculty members of the international symposium 'Valves in the Heart of the Big Apple: Evaluation and Management of Valvular Heart Diseases, this book is intended to complement and supplement the first volume, published in 2002. While the first volume reviews current information on valvular disease pathophysiology, epidemiology and evaluation as well as management strategies for affected patients, the current volume covers areas not discussed in the first and updates information on critical prognostication and management issues. Topics discussed include the selection of patients for surgery, current surgical approaches, natural history and management of selected complex congenital abnormalities involving heart valves, cellular and molecular pathophysiology of myocardial dysfunction. Consideration is also given to prognostication strategies and results as well as technical approaches to measuring disease characteristics. Providing a comprehensive overview of contemporary thinking about valvular heart diseases, this book will be of great value not only to cardiologists and cardiac surgeons, but also to medical students, medical and surgical residents, cardiology and cardiac surgery fellows and general internists.
The Developing Heart
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Author : Marianne J. Legato
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Developing Heart written by Marianne J. Legato and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Heart disease, despite recent improvements, continues to be the single most im portant cause of death and disability in the United States. It is estimated that the direct cost of medical care for cardiovascular disease is $6 billion dollars per year. Data compiled by the National Center for Health Statistics reveal a dramatic de cline in deaths from cardiovascular disease in the United States (greater than 20% since 1968). This phenomenon has been the subject of in-depth study. It is clear that the decline is real and not a statistical artifact. The decrease in mortality has been noted in all sections of the country, though the onset and rate of decline varies in different regions of the country. Both primary prevention, through changes in risk factors, and basic and applied research leading to earlier recognition and im proved treatment have contributed to the decline. They do not fully explain the decline. Further research is needed to clarify this issue. Clinical cardiologists have been exposed to a veritable explosion of new knowl edge of mechanisms of cardiovascular disease, development of new improved non-invasive diagnostic techniques, and the pharmacodynamics of agents affect ing the cardiovascular system. This new knowledge results from contributions made by individuals from diverse disciplines including cellular and molecular bi ologists, geneticists, hematologists, cardiologists, and cardiovascular surgeons.