Molecular Imaging Of Neurodegenerative Disorders

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Molecular Imaging Of Neurodegenerative Disorders

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Author : Donna J. Cross
language : en
Publisher: Springer Nature
Release Date : 2023-09-26

Molecular Imaging Of Neurodegenerative Disorders written by Donna J. Cross and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.

This book provides a comprehensive review of the role of molecular imaging in neurodegenerative diseases. A growing field, molecular imaging of neurodegeneration is becoming increasingly relevant with an aging population, and this book serves to provide both an introduction to the concept and background of neurodegeneration and an update on the most recent imaging advances. Throughout, chapters will review current applications of neuroimaging in neurodegenerative disorders, like dementia and movement disorders, and increase knowledge of quantification and semi-quantification methods for neuroimaging. Imaging methods such as PET/CT and PET/MR are covered, as well as more advanced technologies like artificial intelligence algorithms and novel radiotracers. Chapters are also intended to improve competency in reporting and interpretation skills with structured information on current practice. The book concludes with a collection of up to date practice cases for the interpretation of neurodegeneration in nuclear medicine imaging. This is an ideal guide for nuclear medicine physicians, neuroradiologists, neurologists, residents, trainees, and related medical professionals caring for patients with neurodegeneration.

Joint Imaging Applications In General Neurodegenerative Disease

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Author : Yongxia Zhou
language : en
Publisher:
Release Date : 2021

Joint Imaging Applications In General Neurodegenerative Disease written by Yongxia Zhou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Brain categories.

Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinson's disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations.Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis.In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment.

Imaging In Neurodegenerative Disorders

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Author : Luca Saba
language : en
Publisher: OUP Oxford
Release Date : 2015-01-08

Imaging In Neurodegenerative Disorders written by Luca Saba and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-08 with Medical categories.

Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

Imaging Of The Human Brain In Health And Disease

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Author : Philip Seeman
language : en
Publisher: Elsevier
Release Date : 2013-11-15

Imaging Of The Human Brain In Health And Disease written by Philip Seeman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-15 with Science categories.

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

Neurodegenerative Diseases

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Author : M. Flint Beal
language : en
Publisher: Cambridge University Press
Release Date : 2005-06-02

Neurodegenerative Diseases written by M. Flint Beal and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-02 with Medical categories.

Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Molecular Imaging For Brain Diseases

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Author : Daichi Sone
language : en
Publisher: Springer Nature
Release Date : 2025-04-22

Molecular Imaging For Brain Diseases written by Daichi Sone and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-22 with Science categories.

This volume aims provides timely reviews with special focus on the clinical aspects of brain molecular imaging. The chapters reflect the interdisciplinary nature of the field detailing, glutamate receptor imaging, tau and amyloid imaging, glucose metabolism, opioid receptor, dopamine receptor imaging, brain metabolite measurements by 1H-MRS, and analytical methods using artificial intelligence, which have become extremely important in recent years. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Molecular Imaging for Brain Diseases provides methods to navigate this complex field and inspire a deeper appreciation for the brain’s molecular underpinnings.

Neurodegenerative Disorders

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Author : Orla Hardiman
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-15

Neurodegenerative Disorders written by Orla Hardiman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-15 with Medical categories.

Neurodegenerative Disorders provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions including Alzheimer Disease; Dementia and Cerebrovascular Disease; Parkinson’s Disease; Fronto-Temporal Dementia; Amyotrophic Lateral Sclerosis; Huntington’s Disease; Parkinsonism Plus syndromes and Prion Diseases. Final chapters cover important management issues including the use of palliative care strategies, advance directives and competence. Written by experts in the field internationally Neurodegenerative Disorders is a practical guide for clinicians that will be indispensable for the management of these conditions.

Pet Mr Functional And Molecular Imaging Of Neurological Diseases And Neurosciences

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Author : Jie Lu
language : en
Publisher: Springer Nature
Release Date : 2023-05-29

Pet Mr Functional And Molecular Imaging Of Neurological Diseases And Neurosciences written by Jie Lu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-29 with Medical categories.

This book aims to summarize the research progress of integrated PET/MR brain function and molecular imaging, and more importantly, clinical application and research status of PET/MR of brain imaging from brain diseases to brain science. Starting from the overviews of brain function imaging technology, following chapters introduces clinical application of integrated PET/MR specific brain diseases in details, such as Alzheimer's disease, Parkinson's disease, epilepsy, and brain tumor, etc., which are hot issues of brain science research. It will be a useful reference to residents and practitioners in nuclear medicine, radiology, and neurology, as well as those interested in molecular imaging of brain.

Enzymes In Neurodegenerative Disorders

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Author : Bijo Mathew
language : en
Publisher: Springer Nature
Release Date : 2024-12-24

Enzymes In Neurodegenerative Disorders written by Bijo Mathew and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-24 with Science categories.

This book delves into the correlation between different enzymes and neurodegenerative disorders. It investigates the intricate processes that contribute to the decline of cognitive functions, memory impairment, and other incapacitating symptoms of Alzheimer's disease. The book examines the roles of diverse enzymes in Amyotrophic Lateral Sclerosis and their effects on the motor neurons, leading to muscle weakness, paralysis, and eventual fatality. Moreover, it examines the association between depression and the enzymes responsible, providing a fresh viewpoint on the biochemical foundation of this ailment. Lastly, the book explores the connection between enzymes and Parkinson's disease, discussing the mechanisms that cause the death of dopamine-producing neurons and the related symptoms. By examining the functions of various enzymes in Parkinson's disease, the book presents a distinct outlook on the intricate interplay between enzymes and several neurological conditions, imparting readers with a comprehensive understanding of the fundamental mechanisms that underlie these disorders.

The Molecular And Cellular Basis Of Neurodegenerative Diseases

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Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2018-03-29

The Molecular And Cellular Basis Of Neurodegenerative Diseases written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-29 with Medical categories.

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts