Molecular Mechanisms Of Protein Transport In The Early Secretory Pathway
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Molecular Mechanisms Of Protein Transport In The Early Secretory Pathway
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Author : Erin Christine Gaynor
language : en
Publisher:
Release Date : 1997
Molecular Mechanisms Of Protein Transport In The Early Secretory Pathway written by Erin Christine Gaynor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Vesicular Transport In The Secretory And Endocytic Pathways
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Author : Anne Müsch
language : en
Publisher: Biota Publishing
Release Date : 2014-09-01
Vesicular Transport In The Secretory And Endocytic Pathways written by Anne Müsch and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with Science categories.
The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments. Table of Contents: Compartmentalization Is a Hallmark of Eukaryotic Cells / Organelles Can Be Classified Based on Their Origin / There Are Multiple Entry Points Into the Endomembrane System and a Network of Connecting Trafficking Routes / There Are Exceptions and Extensions to the Classic Trafficking Itineraries / A Mathematical Model Can Explain How Organelle Size Is Established and Maintained / Coats and SNAREs Constitute the Core Machinery for Vesicle Budding and Fusion / A Mathematical Model Explains How Coats and SNAREs Are Sufficient to Generate Organelle Identity / How Vesicle Formation Is Linked to Cargo Incorporation / RabGTPases Are the Master Regulators of Vesicular Traffic / The Mechanisms and Physiological Roles of Endocytosis / Models for Protein Transport in the Golgi Apparatus / Summary / Acknowledgments / References / Author Biography
Molecular Mechanisms Of Gtp Ase Activation In The Early Secretory Pathway
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Author : Aaron Michael Noel Joiner
language : en
Publisher:
Release Date : 2020
Molecular Mechanisms Of Gtp Ase Activation In The Early Secretory Pathway written by Aaron Michael Noel Joiner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Eukaryotic cells utilize vesicular trafficking pathways to transport various proteins and lipids between their organelles. These trafficking pathways are regulated in part via small GTPases. There are two conserved GTPases required for early secretory pathway function: Sar1 and Rab1. The activated, GTP-bound, form of Sar1 recruits the cytoplasmic COPII vesicle coat machinery to the ER membrane in the first stage of the eukaryotic secretory pathway. Active Rab1 recruits tethering factors and other effectors to promote the transport and fusion of COPII vesicles. Understanding the mechanisms involved in activation of these small GTPases is critical for our comprehension of vesicular trafficking. Here, I describe my investigations into the structure and function of the GEFs (guanine nucleotide exchange factors) involved in activating both Sar1 and Rab1. Activation of Sar1 at the ER by Sec12, a membrane-anchored GEF, is the initiating step of the secretory pathway. I solved the structure of a complex between Sar1 and the cytoplasmic GEF domain of Sec12. This structure represents the key nucleotide-free activation intermediate and reveals how the K-loop of Sec12 disrupts the nucleotide binding site of Sar1. I also propose a mechanism for how Sec12 facilitates membrane insertion of the amphipathic helix exposed by Sar1 upon GTP-binding, based on an unexpected basic patch on the GEF domain. Rab1 is activated by the TRAPPIII complex (transport protein particle) in both Golgi trafficking and in autophagy. I determined the molecular structure of the TRAPPIII complex bound to the nucleotide-free Rab1 intermediate and propose a mechanism for its orientation at the membrane surface. I also describe our efforts to unify the apparently discordant observations of TRAPP complexes in budding yeast and mammalian cells. There have been four distinct TRAPP complexes described in budding yeast and only two in mammalian cells. This difference has prevented a clear understanding of the specific functions of TRAPP complexes in all cell types. We demonstrate that as in mammalian cells, budding yeast have only two TRAPP complexes, TRAPPII and TRAPPIII. Our findings lead to a simple yet comprehensive model for TRAPPIII function in all eukaryotic cells.
Trafficking Inside Cells
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Author : Nava Segev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-30
Trafficking Inside Cells written by Nava Segev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-30 with Science categories.
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
Protein Targeting Transport And Translocation
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Author : Ross Dalbey
language : en
Publisher: Elsevier
Release Date : 2002-04-09
Protein Targeting Transport And Translocation written by Ross Dalbey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-09 with Science categories.
Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. Basic principles and techniques Targeting adn sorting sequences Protein export in bacteria Membrane protein integration into ER and bacterial membranes Protein translocation across the ER Disulfide bond formation in prokaryotes and eukaryotes Quality control in the export pathway Import of proteins into organelles The secretory pathway Vesicular transport Spectacular color throughout
The Liver
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Author : Irwin M. Arias
language : en
Publisher: John Wiley & Sons
Release Date : 2020-03-09
The Liver written by Irwin M. Arias and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-09 with Medical categories.
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Encyclopedia Of Molecular Pharmacology
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Author : Stefan Offermanns
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-14
Encyclopedia Of Molecular Pharmacology written by Stefan Offermanns and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-14 with Medical categories.
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Protein Secretion In Bacteria
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Author : Maria Sandkvist
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-02
Protein Secretion In Bacteria written by Maria Sandkvist and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with Science categories.
Protein transport into and across membranes is a fundamental process in bacteria that touches upon and unites many areas of microbiology, including bacterial cell physiology, adhesion and motility, nutrient scavenging, intrabacterial signaling and social behavior, toxin deployment, interbacterial antagonism and collaboration, host invasion and disruption, and immune evasion. A broad repertoire of mechanisms and macromolecular machines are required to deliver protein substrates across bacterial cell membranes for intended effects. Some machines are common to most, if not all bacteria, whereas others are specific to Gram-negative or Gram-positive species or species with unique cell envelope properties such as members of Actinobacteria and Spirochetes. Protein Secretion in Bacteria, authored and edited by an international team of experts, draws together the many distinct functions and mechanisms involved in protein translocation in one concise tome. This comprehensive book presents updated information on all aspects of bacterial protein secretion encompassing: Individual secretory systems–Sec, Tat, and T1SS through the newly discovered T9SS Mechanisms, structures, and functions of bacterial secretion systems Lipoprotein sorting pathways, outer membrane vesicles, and the sortase system Structures and roles of surface organelles, including flagella, pili, and curli Emerging technologies and translational implications Protein Secretion in Bacteria serves as both an introductory guide for students and postdocs and a ready reference for seasoned researchers whose work touches on protein export and secretion. This volume synthesizes the diversity of mechanisms of bacterial secretion across the microbial world into a digestible resource to stimulate new research, inspire continued identification and characterization of novel systems, and bring about new ways to manipulate these systems for biotechnological, preventative, and therapeutic applications.
Green Fluorescent Protein
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Author : Martin Chalfie
language : en
Publisher: John Wiley & Sons
Release Date : 2005-11-18
Green Fluorescent Protein written by Martin Chalfie and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-18 with Science categories.
Since the discovery of the gene for green fluorescent protein (GFP), derived from jellyfish, this protein that emits a green glow has initiated a revolution in molecular biosciences. With this tool, it is now possible to visualize nearly any protein of interest in any cell or tissue of any species. Since the publication of the first edition, there have been tremendously significant technological advances, including development of new mutant variants. Proteins are now available in yellow and blue, and Novel Fluorescent Proteins (NFPs) have expanded their utility in developing biosensors, biological markers, and other biological applications. This updated, expanded new edition places emphasis on the rise of NFPs, including new chapters on NFP properties with detailed protocols, applications of GFPs and NFPs in industry research, and biosensors. This book provides a solid theoretical framework, along with detailed, practical guidance on use of GFPs and NFPs with discussion of potential pitfalls. The expert contributors provide real examples in showing how to tailor GFP/NFP to specific systems, maximize expression, and enhance detection.