Molecular Mechanisms Underlying Prostate Cancer Lymph Node Metastasis

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Molecular Mechanisms Underlying Prostate Cancer Lymph Node Metastasis

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Author : Yiping Zeng
language : en
Publisher:
Release Date : 2006

Molecular Mechanisms Underlying Prostate Cancer Lymph Node Metastasis written by Yiping Zeng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Lymph nodes categories.

Abreg De La Vie Et Des Actions Glorieuses De L Eminentissime Cardinal Armand Jean Du Plessis Duc De Richelieu

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Author :
language : en
Publisher:
Release Date :

Abreg De La Vie Et Des Actions Glorieuses De L Eminentissime Cardinal Armand Jean Du Plessis Duc De Richelieu written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Elucidation Of The Molecular Mechanism Underlying Lymph Node Metastasis In Prostate Cancer

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Author :
language : en
Publisher:
Release Date : 2006

Elucidation Of The Molecular Mechanism Underlying Lymph Node Metastasis In Prostate Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Metastatic spread of prostate cancer is the second leading cause of deaths of men in theUnited States. Although there are many ways to treat non-metastatic form of prostate cancer, only androgen-deprivation therapy is available for the extensive stage. Again, the cancerwill often progress to an androgen refractory (independent), metastatic stage. Recent reportshave suggested that the expression of VEGF-C and its receptor VEGFR-3 are directly correlatedwith lymph node dissemination in prostate cancer. This finding leads us to think thatunderstanding the role of angiogenic molecules like VEGF-C, -D in molecular detail forlymphatic formation in prostate cancer will provide us the information regarding theirrelationship with lymph node metastasis. We have observed significant increase in reactiveoxygen species and activation of small GTPase RalA upon androgen withdrawal, which in turnupregulates VEGF-C in prostate cancer cells. Interestingly our results suggest a function ofVEGF-C, which is directly related to its role in increasing the metastatic propensity ofprostate cancer rather than inducing lymphangiogenesis.

Cancer Metastasis Through The Lymphovascular System

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Author : Stanley P. Leong
language : en
Publisher: Springer Nature
Release Date : 2022-06-24

Cancer Metastasis Through The Lymphovascular System written by Stanley P. Leong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-24 with Medical categories.

This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.

Precision Molecular Pathology Of Prostate Cancer

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Author : Brian D. Robinson
language : en
Publisher: Springer
Release Date : 2018-02-13

Precision Molecular Pathology Of Prostate Cancer written by Brian D. Robinson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-13 with Medical categories.

This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention

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Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11

Cancer Metastasis Molecular And Cellular Mechanisms And Clinical Intervention written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.

This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.

Experimental And Clinical Metastasis

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Author : Julia V. Burnier
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-01-04

Experimental And Clinical Metastasis written by Julia V. Burnier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-04 with Medical categories.

Metastatic disease is the most lethal aspect of human malignancies, making the understanding and continued research of the process of metastasis a crucial step in treating cancer. The proposed book, entitled “Experimental and Clinical Metastasis: A Comprehensive Review” aims to provide a clear and extensive review of the clinical and experimental implications of metastatic disease. This work focuses on recent contributions to the field of metastasis, and will highlight crucial findings in the molecular understanding of disseminated disease as well as standard and personalized medicine currently being investigated in the clinic. Topics will include, among many, gene properties of metastatic cells, molecular mechanisms of tumour growth and spread, animal models of metastasis, and clinical implications, markers and treatment for metastatic disease. With the participation of worldwide experts in the field of oncology, from major academic and government centres, this book will provide a leading manual for the study of the metastatic process, from benchside science to bedside care. In this light, the proposed book will facilitate classroom learning for both medical and graduate students, as well as serve as a tool for physicians and researchers interested in the metastatic process. In addition, this book will include the latest advances in basic science as well as leading technologies and theories of targeting metastatic cells. Most importantly, not only will basic and clinical aspects be discussed, but furthermore, the translational aspect of research in metastatic diseases will be emphasized.

Prostate Cancer

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Author : Scott M. Dehm
language : en
Publisher: Springer Nature
Release Date : 2020-01-03

Prostate Cancer written by Scott M. Dehm and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-03 with Medical categories.

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

Molecular Biology Of Prostate Cancer

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Author : Manfred Wirth
language : en
Publisher: Walter de Gruyter
Release Date : 2013-05-22

Molecular Biology Of Prostate Cancer written by Manfred Wirth and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.

Cancer Metastasis Through The Lymphovascular System

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Author : S. David Nathanson
language : en
Publisher:
Release Date : 2022

Cancer Metastasis Through The Lymphovascular System written by S. David Nathanson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Cancer categories.

This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .