Elucidation Of The Molecular Mechanism Underlying Lymph Node Metastasis In Prostate Cancer
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Elucidation Of The Molecular Mechanism Underlying Lymph Node Metastasis In Prostate Cancer
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Author :
language : en
Publisher:
Release Date : 2006
Elucidation Of The Molecular Mechanism Underlying Lymph Node Metastasis In Prostate Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Metastatic spread of prostate cancer is the second leading cause of deaths of men in theUnited States. Although there are many ways to treat non-metastatic form of prostate cancer, only androgen-deprivation therapy is available for the extensive stage. Again, the cancerwill often progress to an androgen refractory (independent), metastatic stage. Recent reportshave suggested that the expression of VEGF-C and its receptor VEGFR-3 are directly correlatedwith lymph node dissemination in prostate cancer. This finding leads us to think thatunderstanding the role of angiogenic molecules like VEGF-C, -D in molecular detail forlymphatic formation in prostate cancer will provide us the information regarding theirrelationship with lymph node metastasis. We have observed significant increase in reactiveoxygen species and activation of small GTPase RalA upon androgen withdrawal, which in turnupregulates VEGF-C in prostate cancer cells. Interestingly our results suggest a function ofVEGF-C, which is directly related to its role in increasing the metastatic propensity ofprostate cancer rather than inducing lymphangiogenesis.
Abreg De La Vie Et Des Actions Glorieuses De L Eminentissime Cardinal Armand Jean Du Plessis Duc De Richelieu
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Author :
language : en
Publisher:
Release Date :
Abreg De La Vie Et Des Actions Glorieuses De L Eminentissime Cardinal Armand Jean Du Plessis Duc De Richelieu written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Molecular Mechanisms Underlying Prostate Cancer Lymph Node Metastasis
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Author : Yiping Zeng
language : en
Publisher:
Release Date : 2006
Molecular Mechanisms Underlying Prostate Cancer Lymph Node Metastasis written by Yiping Zeng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Lymph nodes categories.
Molecular Biology Of Prostate Cancer
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Author : Manfred Wirth
language : en
Publisher: Walter de Gruyter
Release Date : 2013-05-22
Molecular Biology Of Prostate Cancer written by Manfred Wirth and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.
Atlas Of Lymphoscintigraphy And Sentinel Node Mapping
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Author : Giuliano Mariani
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-23
Atlas Of Lymphoscintigraphy And Sentinel Node Mapping written by Giuliano Mariani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-23 with Medical categories.
Although lymphoscintigraphy was originally introduced into clinical routine for identification of the cause of peripheral edema, more recently it has been widely applied for radioguided biopsy of the sentinel lymph node in patients with solid cancers. The procedure is now considered crucial for adequate planning of oncologic surgery in a growing number of cancers. This atlas presents a collection of richly illustrated teaching cases that demonstrate the clinical relevance and impact of lymphoscintigraphy in different pathologic conditions. After introductory chapters on the anatomy, physiology, and pathophysiology of lymphatic circulation, the role of lymphoscintigraphy in differential diagnosis of peripheral edema and characterization of intracavitary lymph effusions is addressed. The principal focus of the book, however, is on the use of lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. The most commonly observed lymphoscintigraphic patterns are depicted, and anatomic variants and technical pitfalls of the procedure receive careful attention. The role of tomographic multimodality imaging is also considered. The atlas will be an excellent learning tool for residents in nuclear medicine and other specialists with an interest in the field.
Inflammation And Cancer
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Author : Bharat B. Aggarwal
language : en
Publisher: Springer
Release Date : 2014-05-12
Inflammation And Cancer written by Bharat B. Aggarwal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Introduction To Cancer Metastasis
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Author : Aamir Ahmad
language : en
Publisher: Academic Press
Release Date : 2016-11-14
Introduction To Cancer Metastasis written by Aamir Ahmad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Medical categories.
Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe
The Oncogenomics Handbook
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Author : William J. LaRochelle
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-09
The Oncogenomics Handbook written by William J. LaRochelle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-09 with Medical categories.
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Metastatic Cancer Clinical And Biological Perspectives
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Author : Rahul Jandial
language : en
Publisher: CRC Press
Release Date : 2013-08-08
Metastatic Cancer Clinical And Biological Perspectives written by Rahul Jandial and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-08 with Medical categories.
Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Oral Cancer Detection
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Author : Prashanth Panta
language : en
Publisher: Springer
Release Date : 2019-01-04
Oral Cancer Detection written by Prashanth Panta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-04 with Medical categories.
This monograph equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection. All the methods employed in the oral cancer context are considered, from simple ones like oral screening to more complex emerging optical methods and biomarker identification strategies. Individual chapters focus on conventional oral screening and application of vital stains, optical methods like white light based fluorescence-reflectance imaging, narrow band imaging, direct-oral-microscopy, and more advanced methods like optical coherence tomography, an in-vivo optical biopsy technique, and photo-acoustic imaging that allows visualization of deeper tissue changes. Novel electrical methods like bio-impedance assessment, occult biophysical methods like crystallization test, and the most promising salivary biomarkers and point-of-care opportunities are covered. Helpful information is also provided on essential topics including, oral potentially malignant disorders, biological aspects and molecular mechanisms underlying oral cancer progression, global epidemiology, concept of diagnostic delays, traditional imaging, and classic histopathology and microscopic features. The newer techniques are currently of active research interest, and can soon become powerful chair-side tools with potential to reduce diagnostic delays and improve survival.