Monocyte Heterogeneity And Function

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Monocyte Heterogeneity And Function

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Author : Pierre Guermonprez
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-11

Monocyte Heterogeneity And Function written by Pierre Guermonprez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-11 with Medical categories.

Heterogeneity Of Mononuclear Phagocytes

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Author : Othmar Förster
language : en
Publisher:
Release Date : 1981

Heterogeneity Of Mononuclear Phagocytes written by Othmar Förster and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Nature categories.

Monocyte Heterogeneity And The Formation Of Functionally Distinct Osteoclasts

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Author :
language : en
Publisher:
Release Date : 2017

Monocyte Heterogeneity And The Formation Of Functionally Distinct Osteoclasts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Macrophages And Related Cells

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Author : Michael A. Horton
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Macrophages And Related Cells written by Michael A. Horton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.

To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . .

Heterogeneity Of Monocytes And Monocyte Derived Cells In Human Lymph Nodes And Bone Marrow

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Author : Marwan Qubaja
language : en
Publisher:
Release Date : 2008

Heterogeneity Of Monocytes And Monocyte Derived Cells In Human Lymph Nodes And Bone Marrow written by Marwan Qubaja and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

Background: Human monocytes originate in the bone marrow from a common myeloid progenitor, and they are then released into the peripheral blood. Circulating monocytes are capable of differentiating into morphologically and functionally heterogeneous effector cells, including macrophages and dendritic cells. Based on CD14 and CD16 expression, human peripheral blood monocytes can be divided into a major CD14highCD16- population and two minor CD14highCD16+ and CD14dimCD16+ subpopulations. Objective: We aimed to study the heterogeneity of monocytes and monocyte-derived cells in human bone marrow and lymph nodes, in reactive and tumoral states, with the help of new monocyte/macrophage-derived markers evaluable on paraffin-embedded tissue. Materials and Methods: For this purpose, we studied a series of 33 bone marrow biopsies (BMBs) consisted of 8 normal BMBs, 15 cases of chronic myelomonocytic leukemia (CMML) and 10 cases of chronic myeloid leukemia (CML). We also studied a series of 27 lymph node biopsies including 15 biopsies of reactive lymph nodes and 12 diffuse large B cell lymphoma (DLBCL) nodal biopsies. We evaluated the expression of the following markers on bone marrow and lymph node biopsies: MPO, CD68 (KP1 and PG-M1), CD15, Glycophorin C, CD14, CD16, CD169, CD163, DC-SIGN, CD1a, CD11c, and CD123. Results: In normal BMBs, we clearly identified CD14+ monocytes with mono or bilobated nuclei, very difficult to differentiate from some neutrophils on morphology. These CD14+ monocytes were negative for PG-M1 and CD163. CD16+ monocytes were extremely rare on normal BMBs. Medullary macrophages and granulocytes were CD14-. We showed a significant expansion of dispersed CD14+ monocytes in CMML compared to CML and normal BMBs, but no increase in CD16+ monocytes. We also showed a significant decrease in the number of granulocytes expressing MPO, CD15 and CD16 in CMML, probably related to dysgranulopoiesis often encounterd in this disease. In reactive human lymph nodes, we showed that most sinusoidal histiocytes were strongly positive for CD14, CD16, CD169, and DC-SIGN. CD163 and CD11c variably stained sinusoidal histiocytes and a few cells in the germinal center having the morphology of dendritic cells. However, sinusoidal histiocytes with erythrophagocytosis lacked CD14, but expressed CD16 and CD169. In the lymph nodes of Kikuchi Fujimoto's disease, we demonstrated a strong expansion of the number of MPO+ monocyte-derived cells, and numerous monocyte-derived cells were also positive for CD123, CD14, CD11c and CD163. In DLBCL, we demonstrated a strong expansion of CD14+ monocyte-derived cells, except in cases associated with numerous mitosis, apoptotic bodies, and tingible body macrophages. We showed no increase in number of monocyte-derived cells positive for CD169, CD1a or DC-SIGN. Conclusion: We demonstrated that CD14 immunostaining makes it possible to clearly identify the rare monocyte population on normal BMBs and this is therefore useful for the histopathological diagnosis of CMML, being probably mainly associated with the expansion of the CD14+CD16- monocyte subpopulation. We also demonstrated the morphological and phenotypical heterogeneity of monocyte-derived cells in human lymph nodes. In reactive human lymph nodes, sinusoidal histiocytes are CD14+CD16+ whereas these sinusoidal histiocytes with erythrophagocytosis are CD14-CD16+. DLBCL is associated with the presence of numerous CD14+ monocyte-derived cells except in cases where numerous mitosis and tingible body macrophages are found. Whether these phenotypical changes are due to the recruitment of a different monocyte subpopulation (CD14+CD16-, CD14-CD16+) or to a downregulation of some receptors remains to be demonstrated. However, these changes are probably linked to the differential effector functions of these monocyte-derived cells.

Defining Guinea Pig Monocyte Heterogeneity Using Cells Separated By Counter Flow Centrifugation Elutriation

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Author : Stephen Joseph Noga
language : en
Publisher:
Release Date : 1983

Defining Guinea Pig Monocyte Heterogeneity Using Cells Separated By Counter Flow Centrifugation Elutriation written by Stephen Joseph Noga and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with categories.

Hemopoietic System

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Author : Thomas C. Jones
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Hemopoietic System written by Thomas C. Jones and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the hemopoietic system, is the eighth volume of a set prepared under the sponsorship of the International Life Sciences In stitute (ILSI).

Human Monocytes

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Author : Marek Zembala
language : en
Publisher:
Release Date : 1989

Human Monocytes written by Marek Zembala and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.

Monocytes represent one of the major types of white blood cells in man which prevent infection by ingesting and killing invading pathogens and by releasing factors which stimulate and regulate lymphocytes. Monocytes "purify" the blood, removing immune complexes, mediating inflammatory responses, and initiating tissue repair. Human Monocytes represents an up-to-date, definitive account of this important cell. It covers the cells biochemical, immunological, and inflammatory functionsand its role in many diseases, including asthma, atherosclerosis, rheumatoid arthritis, and AIDS.

Disorders Of The Monocyte Macrophage System

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Author : F. Schmalzl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Disorders Of The Monocyte Macrophage System written by F. Schmalzl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

The origin and function of normal monocytes and macrophages have been clearly defined by extensive investigations in human and in animal models. The central importance ofthis cell system for the biological defense mecha nisms is well established: phagocytosis, inactivation and destruction of organic and inorganic materials, an important role in the initiation ofhumo ral and cell mediated immunological responses, and the secretion of a varie ty of chemical mediator and effector substances are the most important fea tures of this ontogenetically ancient cell system. However, the data on this cellular system are rather recent, and this may explain why relatively little attention has been payed to the pathology of the monocyte-macrophage system (MMS) until now. In addition, this monograph should focus attention on the secondarypa thophysiological implications of the MMS in disorders not primarily origi nating from this system. Several techniques are available to identify even abnormal individuals of this cell system and, therefore, can be employed for the study of severely altered or neoplastic monocytic cells.

Inflammation 4 Volume Set

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Author : Jean-Marc Cavaillon
language : en
Publisher: John Wiley & Sons
Release Date : 2018-02-20

Inflammation 4 Volume Set written by Jean-Marc Cavaillon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-20 with Medical categories.

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.