Mouse Models Of Developmental Genetic Disease
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Mouse Models Of Developmental Genetic Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2011-09-06
Mouse Models Of Developmental Genetic Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-06 with Science categories.
Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies. Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease
Mouse Models Of The Nuclear Envelopathies And Related Diseases
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Author :
language : en
Publisher: Elsevier
Release Date : 2014-06-16
Mouse Models Of The Nuclear Envelopathies And Related Diseases written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Science categories.
Volume 109 of Current Topics in Developmental Biology covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease. Covers the area of mouse models of developmental genetic disease International board of authors Provides a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s, muscle aging, lipodystrophy, and more
Mouse Models Of Development And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-04-20
Mouse Models Of Development And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-20 with Science categories.
Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Mouse Models of Development and Disease
Mouse Models In The Study Of Genetic Neurological Disorders
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Author : Brian Popko
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mouse Models In The Study Of Genetic Neurological Disorders written by Brian Popko and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.
Mouse Genetics
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Author : Shree Ram Singh
language : en
Publisher: Humana
Release Date : 2022-03-06
Mouse Genetics written by Shree Ram Singh and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-06 with categories.
Mouse Models Of Human Cancer
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Author : Eric C. Holland
language : en
Publisher: John Wiley & Sons
Release Date : 2004-08-27
Mouse Models Of Human Cancer written by Eric C. Holland and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-27 with Science categories.
Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.
Mouse Models Of Developmental Genetic Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2008-12-29
Mouse Models Of Developmental Genetic Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-29 with Science categories.
Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies. * Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area * Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution * Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease
Scientific Frontiers In Developmental Toxicology And Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-12-21
Scientific Frontiers In Developmental Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-12-21 with Nature categories.
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Inborn Errors Of Development
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Author : Charles J. Epstein
language : en
Publisher: Oxford University Press, USA
Release Date : 2004
Inborn Errors Of Development written by Charles J. Epstein and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.
Genetically Engineered Mice Handbook
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Author : John P. Sundberg
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Genetically Engineered Mice Handbook written by John P. Sundberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
This comprehensive book covers all aspects of the field of genetically engineered laboratory mice, including the creation of mutant mice through mouse models for developmental biology and the monitoring of laboratory mouse colonies. Written by leading biomedical investigators, pathologists, and clinicians, this book presents systematic approaches for analyzing mutant laboratory mice for specific medical applications. It provides a variety of methods for creating mutant mice, while covering legal aspects of mutant and inbred laboratory mice as well as the use and maintenance of international databases.