Mouse Retinal Phenotyping
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Mouse Retinal Phenotyping
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Author : Naoyuki Tanimoto
language : en
Publisher: Humana
Release Date : 2019-04-05
Mouse Retinal Phenotyping written by Naoyuki Tanimoto and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-05 with Science categories.
The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Standards Of Mouse Model Phenotyping
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Author : Martin Hrabé de Angelis
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-03
Standards Of Mouse Model Phenotyping written by Martin Hrabé de Angelis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Science categories.
This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.
Morphological Mouse Phenotyping
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Author : Jesus Ruberte
language : en
Publisher: Elsevier
Release Date : 2017-01-27
Morphological Mouse Phenotyping written by Jesus Ruberte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with Medical categories.
Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organs Includes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona) Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology
Systematic Evaluation Of The Mouse Eye
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Author : Richard S. Smith
language : en
Publisher: CRC Press
Release Date : 2001-12-20
Systematic Evaluation Of The Mouse Eye written by Richard S. Smith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-12-20 with Medical categories.
Completion of the first phase of the Human Genome Project has presented scientists with a mountain of new information. The availability of all human genes and their locations is exciting, but their mechanisms of action and interaction with other genes are often unknown. Certain variations in the environment and characteristics of human genes make i
What S Wrong With My Mouse
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Author : Jacqueline N. Crawley
language : en
Publisher: John Wiley & Sons
Release Date : 2007-05-11
What S Wrong With My Mouse written by Jacqueline N. Crawley and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-11 with Science categories.
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.
Retinal Degenerations
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Author : Joyce Tombran-Tink
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-06
Retinal Degenerations written by Joyce Tombran-Tink and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-06 with Medical categories.
This book presents new and noteworthy research into retinal diseases. It focuses on what we currently know about the environment, genetics and mechanisms that lead to retinal degenerations, new diagnostics, and innovative therapeutic modalities to preserve vision. Written by renowned scientific investigators, this innovative collection of treatment strategies and technological discoveries allows for the realistic translation of research into practice.
Retinal Degeneration
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Author : Bernhard Weber
language : en
Publisher: Humana Press
Release Date : 2012-11-13
Retinal Degeneration written by Bernhard Weber and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Science categories.
Over the past decades, knowledge about the cellular and molecular basis underlying the visual process has remarkably increased. In Retinal Degeneration: Methods and Protocols, expert researchers in the field provide a guide of relevant and state-of-the-art methods for studying retinal homeostasis and disease. These include methods and techniques for addressing cell culture systems and animal models of disease, their generation, their phenotypic and molecular characterization as well as their use in therapeutic approaches to the retina. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Retinal Degeneration: Methods and Protocols aids scientists in continuing to study the cutting-edge techniques of retinal cell biology in health and disease.
The Molecular And Cellular Basis Of Retinal Diseases
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Author : Steven J. Pittler
language : en
Publisher: MDPI
Release Date : 2020-12-29
The Molecular And Cellular Basis Of Retinal Diseases written by Steven J. Pittler and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-29 with Science categories.
There are more than 300 genes that have been identified which carry mutations that cause various forms of retinal dysfunction and degeneration, making the study of retinal diseases a subject of high relevance. In this compendium of original and review articles, many of the diseases and pathways associated with disorders of the retina are examined using animal models, to provide the reader with a good overview of current retinal research. Within this volume, you will find research reports on many of the most prominent retinal disorders, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), choroidal neovascularization (CNV), and retinitis pigmentosa (RP). We hope that the work presented here will stimulate new ideas and lead to effective treatments for retinal diseases.
Chemical Anatomy Of The Zebrafish Retina
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Author : Stephen Yazulla
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-08-31
Chemical Anatomy Of The Zebrafish Retina written by Stephen Yazulla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-31 with Medical categories.
Chemical Anatomy of the Zebrafish Retina is an excellent reference, providing excellent images and insight into one of the most increasingly important model systems in neurobiology today. Papers include a visually stunning molecular phenotype atlas and an exhaustive treatment of the neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
Mouse As A Model Organism
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Author : Cord Brakebusch
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-29
Mouse As A Model Organism written by Cord Brakebusch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-29 with Medical categories.
Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.