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Multiple Sclerosis And Related Disorders Challenges And Approaches To Mechanisms Biomarkers And Therapeutic Targets


Multiple Sclerosis And Related Disorders Challenges And Approaches To Mechanisms Biomarkers And Therapeutic Targets
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Multiple Sclerosis And Related Disorders Challenges And Approaches To Mechanisms Biomarkers And Therapeutic Targets


Multiple Sclerosis And Related Disorders Challenges And Approaches To Mechanisms Biomarkers And Therapeutic Targets
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Author : Jinzhou Feng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-28

Multiple Sclerosis And Related Disorders Challenges And Approaches To Mechanisms Biomarkers And Therapeutic Targets written by Jinzhou Feng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-28 with Medical categories.


Multiple sclerosis (MS) is an autoimmune condition that causes inflammatory damage to the central nervous system. The pathologic features are diffuse and focal inflammation, demyelination, gliosis, and neuronal damage in the optic nerves, brain, and spinal cord. Multiple sclerosis remains a challenging and disabling disease. There is a greater understanding of the underlying genetic and environmental factors driving the disorder, including low vitamin D levels, smoking, and obesity. Early and accurate diagnosis is essential and needs to be supported by diagnostic criteria, including imaging and spinal fluid abnormalities in patients with clinically isolated syndromes. Other demyelinating diseases are neuromyelitis optica spectrum disorders (NMOSD), anti-myelin oligodendrocyte glycoprotein antibody disease (MOGAD), and acute disseminated encephalomyelitis (ADEM).



Multiple Sclerosis And Related Disorders


Multiple Sclerosis And Related Disorders
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Author : Douglas S. Goodin
language : en
Publisher: Elsevier
Release Date : 2014-02-05

Multiple Sclerosis And Related Disorders written by Douglas S. Goodin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-05 with Medical categories.


Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners. - A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis - Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options - Each chapter is translational and focuses on current research and impact on diagnosis and treatment options



Primer On Multiple Sclerosis


Primer On Multiple Sclerosis
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Author : Barbara S. Giesser
language : en
Publisher: Oxford University Press
Release Date : 2011

Primer On Multiple Sclerosis written by Barbara S. Giesser and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.


Primer on Multiple Sclerosis is a practical guide to the management of persons with Multiple Sclerosis. It provides guidelines for diagnosis and treatment of both symptoms and the underlying disease process, as well as updates on current basic science and research initiatives.



Rna At A Breaking Point Cytoplasmic Cleavage And Other Post Transcriptional Rna Processing In Neurodevelopment And Disease


Rna At A Breaking Point Cytoplasmic Cleavage And Other Post Transcriptional Rna Processing In Neurodevelopment And Disease
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Author : Catia Andreassi
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-29

Rna At A Breaking Point Cytoplasmic Cleavage And Other Post Transcriptional Rna Processing In Neurodevelopment And Disease written by Catia Andreassi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-29 with Science categories.




Advances In Genomics


Advances In Genomics
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Author : Vijai Singh
language : en
Publisher: Springer Nature
Release Date : 2024-07-31

Advances In Genomics written by Vijai Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-31 with Science categories.


This book provides a comprehensive overview of genomics and its diverse applications. Chapters cover genomics data generation methods, computational tools, gene annotation, transcriptomics, DNA barcoding, next-generation sequencing, functional genomics, metagenomics, synthetic genomics, microarray analysis, nutrigenomics, genome editing, and more. This book offers a valuable source of information for not only beginners in genomics, but also for students, researchers, scientists, clinicians, practitioners, policymakers, and stakeholders who are interested in harnessing the potential of genomics in many areas.



Multiple Sclerosis Therapeutics


Multiple Sclerosis Therapeutics
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Author : Jeffrey A. Cohen
language : en
Publisher: Cambridge University Press
Release Date : 2011-10-20

Multiple Sclerosis Therapeutics written by Jeffrey A. Cohen and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-20 with Medical categories.


This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.



Neuroprotection


Neuroprotection
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Author : Swapan K. Ray
language : en
Publisher: Springer Nature
Release Date : 2024-03-01

Neuroprotection written by Swapan K. Ray and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-01 with Science categories.


This volume contains cutting-edge molecular biology methods on neuroprotective mechanisms and specific preclinical models of the CNS injury, iseases and planning translation. Chapters guide readers through neuropathology, neuroprotection, Alzheimer’s disease, amyotrophic lateral sclerosis, ALS, Huntington’s disease , multiple sclerosis, Parkinson’s disease, spinal cord injury, traumatic brain injury, and ischemic brain injury. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuroprotection: Methods and Protocols aims to ensure successful results in the further study of this vital field.



Current Trends In The Diagnosis And Management Of Metabolic Disorders


Current Trends In The Diagnosis And Management Of Metabolic Disorders
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Author : Seth Kwabena Amponsah
language : en
Publisher: CRC Press
Release Date : 2023-12-14

Current Trends In The Diagnosis And Management Of Metabolic Disorders written by Seth Kwabena Amponsah and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-14 with Medical categories.


This volume provides an overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies. Metabolic disorders occur when metabolic processes in the body are disrupted. They contribute a significant burden to human health globally. They can be congenital or acquired, for example, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, osteopenia, mild-moderate hypovitaminosis D, erectile dysfunction, dyslipidemia, and thyroiditis. Metabolic disorders have gained significant importance due to the exponential increase in obesity worldwide. Early diagnosis of metabolic disorders is important in order to employ lifestyle and risk factor modification. Features: An overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies Describes recent trends in diagnosis of metabolic disorders Discusses management and treatment of metabolic diseases Allows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compounds Suitable globally for graduate and postgraduate students studying metabolic diseases



Biomarkers In Toxicology


Biomarkers In Toxicology
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Author : Ramesh C Gupta
language : en
Publisher: Academic Press
Release Date : 2019-02-13

Biomarkers In Toxicology written by Ramesh C Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-13 with Medical categories.


Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. - Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers - Includes completely revised chapters, along with additional chapters on the newest developments in the field - Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure - Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more



Advancing Healthcare Through Personalized Medicine


Advancing Healthcare Through Personalized Medicine
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Author : Priya Hays
language : en
Publisher: CRC Press
Release Date : 2017-02-24

Advancing Healthcare Through Personalized Medicine written by Priya Hays and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-24 with Business & Economics categories.


This innovative book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it will help mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to underlying concepts at the heart of personalized medicine - pharmacogenomics, targeted therapies and individualized diagnosis and treatment - and shows how, with the advent of genomic technologies, clinicians will have the capability to predict and diagnose disease more efficiently. Advocating a patient-centred approach at the heart of care, this introduction to personalized medicine, the science behind it, its economic effects, its effects upon patients and its overall implications for society will be invaluable to clinicians, to healthcare providers and to patients.