Mutation Detection
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Mutation Detection
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Author : R. G. H. Cotton
language : en
Publisher: IRL Press
Release Date : 1998-02-05
Mutation Detection written by R. G. H. Cotton and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02-05 with Science categories.
Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.
Pcr Mutation Detection Protocols
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Author : Bimal D. M. Theophilus
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Pcr Mutation Detection Protocols written by Bimal D. M. Theophilus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
1Bimal D. Theophilus and Ralph Rapley provide biological and clinical investigators with a comprehensive collection of new, recent, and updated PCR-based screening methods suitable for detecting the presence of both known and novel mutations. The methods cover point mutations (e.g., ASO-PCR, SSCP, DGGE, chemical cleavage), deletions (multiplex PCR, FISH, blotting), non-sense mutations (PTT), and more. The new and exciting techniques of DNA array analysis, along with such recently developed experimental methods as conformation-sensitive gel electrophoresis, are also included. Each chapter explains the basic theory behind the technique and provides valuable notes essential for its successful execution.
Guide To Mutation Detection
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Author : Human Genome Organisation
language : en
Publisher: John Wiley & Sons
Release Date : 2005-02-03
Guide To Mutation Detection written by Human Genome Organisation and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-02-03 with Science categories.
Guide to both the theory and practice of mutation detection technology, including detailed practical protocols that are derived from courses run by the Human Genome Organization (HUGO). Guide to Mutation Detection offers the only single source for assessing the molecular biological tools for mutation analysis in order to design an experiment. The first section reviews topics such as key technologies, mutation scanning, cleavage, quality control, high throughput approaches, databases, and nomenclature. The second part covers step-by-step protocols and discussion of methods such as tag-array minisequencing, electronic hybridization, pyrosequencing, fluorescent SSCP, DHPLC, array CGH, and MADGE.
Mutation Detection
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Author : Richard G. H. Cotton
language : en
Publisher:
Release Date : 2023
Mutation Detection written by Richard G. H. Cotton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Molecular genetics categories.
Fundamental to the study of cancer is the ability to detect mutations. This book aims to critically review the field. It refers to methodology and protocols, gives illustrative examples and puts the whole emerging field in context. The question of ethics is also discussed.
Laboratory Protocols For Mutation Detection
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Author : Ulf Landegren
language : en
Publisher: Oxford University Press, USA
Release Date : 1996
Laboratory Protocols For Mutation Detection written by Ulf Landegren and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with History categories.
Random mutagenesis and gene knockout experiments are standard techniques to investigate the effects of specific genetic factors. In recent years, improved methods for mutation analysis have greatly simplified the study of natural mutations and sequence variants to learn more about the function of our genetic makeup, and to predict and finely diagnose disease. Accordingly, mutation analysis is assuming a rapidly increasing importance in academic, clinical, and industrial research. This collection of protocols for mutation detection techniques arose as a set of formulas shared among participants at a HUGO-sponsored workshop held in Visby in 1995, where an impressive list of originators and major users of mutation detection methods gathered to exchange experiences. The techniques included span a wide range of areas; some are currently in use, while others illustrate principles that may be of importance in future test formats.
The Handbook Of Plant Mutation Screening
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Author : Khalid Meksem
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-21
The Handbook Of Plant Mutation Screening written by Khalid Meksem and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-21 with Science categories.
Induced mutagenesis is a common and promising method for screening for new crops with improved properties. This title introduces the different methods and then focuses on the screening, detection and analysis of the novel mutations. Written by a global team of authors the book is an indispensable tool for all scientists working on crop breeding in industry and academia.
Pcr Mutation Detection Protocols
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Author : Bimal D. M. Theophilus
language : en
Publisher:
Release Date : 2002
Pcr Mutation Detection Protocols written by Bimal D. M. Theophilus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Mutation (Biology) categories.
Technologies For Detection Of Dna Damage And Mutations
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Author : G.P. Pfeifer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Technologies For Detection Of Dna Damage And Mutations written by G.P. Pfeifer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exposure to a carcinogen, tumor develop ment, and genetic changes in tumor DNA have been established. To understand mutagenesis processes in more detail at the molecular level, we need to know the type and frequency of DNA adducts within cells, their distribution along genes and specific DNA sequences, as well as the rates at which they are repaired. We also need to know what types of mutations are produced and which gene positions are most prone to mutagenesis. This book provides a collection of techniques that are useful in mutagenesis research. The book is divided into three parts. In Part I, methods for DNA damage and repair analysis are provided.
Pcr Mutation Detection Protocols
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Author : Bimal D. M. Theophilus
language : en
Publisher: Springer
Release Date : 2010-10-28
Pcr Mutation Detection Protocols written by Bimal D. M. Theophilus and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-28 with Medical categories.
1Bimal D. Theophilus and Ralph Rapley provide biological and clinical investigators with a comprehensive collection of new, recent, and updated PCR-based screening methods suitable for detecting the presence of both known and novel mutations. The methods cover point mutations (e.g., ASO-PCR, SSCP, DGGE, chemical cleavage), deletions (multiplex PCR, FISH, blotting), non-sense mutations (PTT), and more. The new and exciting techniques of DNA array analysis, along with such recently developed experimental methods as conformation-sensitive gel electrophoresis, are also included. Each chapter explains the basic theory behind the technique and provides valuable notes essential for its successful execution.
Mutation Detection 2001
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Author : Damjan Glavač
language : en
Publisher:
Release Date : 2001
Mutation Detection 2001 written by Damjan Glavač and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.