Technologies For Detection Of Dna Damage And Mutations
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Technologies For Detection Of Dna Damage And Mutations
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Author : G.P. Pfeifer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Technologies For Detection Of Dna Damage And Mutations written by G.P. Pfeifer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exposure to a carcinogen, tumor develop ment, and genetic changes in tumor DNA have been established. To understand mutagenesis processes in more detail at the molecular level, we need to know the type and frequency of DNA adducts within cells, their distribution along genes and specific DNA sequences, as well as the rates at which they are repaired. We also need to know what types of mutations are produced and which gene positions are most prone to mutagenesis. This book provides a collection of techniques that are useful in mutagenesis research. The book is divided into three parts. In Part I, methods for DNA damage and repair analysis are provided.
Dna Damage Detection In Situ Ex Vivo And In Vivo
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Author : Vladimir V. Didenko
language : en
Publisher: Humana Press
Release Date : 2010-11-08
Dna Damage Detection In Situ Ex Vivo And In Vivo written by Vladimir V. Didenko and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-08 with Medical categories.
Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology. In DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols, expert researchers explore the latest advances in the area, covering both recent and established techniques to detect and quantify DNA damage at scales ranging from subcellular to the level of a whole live organism. Chapters present all major assays used in molecular and cellular biology for the labeling of DNA damage in situ, ex vivo, and in vivo. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embryology, experimental pharmacology, drug design, and environmental science.
2019 Innovations In Power And Advanced Computing Technologies I Pact
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Author :
language : en
Publisher:
Release Date : 2019
2019 Innovations In Power And Advanced Computing Technologies I Pact written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Mutation Detection
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Author : R. G. H. Cotton
language : en
Publisher: IRL Press
Release Date : 1998-02-05
Mutation Detection written by R. G. H. Cotton and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-02-05 with Science categories.
Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.
Protein Phosphorylation In Human Health
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Author : Cai Huang
language : en
Publisher: IntechOpen
Release Date : 2012-09-06
Protein Phosphorylation In Human Health written by Cai Huang and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-06 with Medical categories.
15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.
Dna Damage Recognition
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Author : Wolfram Siede
language : en
Publisher: CRC Press
Release Date : 2005-09-19
Dna Damage Recognition written by Wolfram Siede and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-19 with Medical categories.
Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employe
Dna Repair Mechanisms
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Author : ICN Pharmaceuticals, inc
language : en
Publisher:
Release Date : 1978
Dna Repair Mechanisms written by ICN Pharmaceuticals, inc and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Science categories.
DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are ...
Dna Repair Protocols
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Author : Daryl S. Henderson
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Dna Repair Protocols written by Daryl S. Henderson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
The first edition of this book, published in 1999 and called DNA Repair Protocols: Eukaryotic Systems, brought together laboratory-based methods for studying DNA damage and repair in diverse eukaryotes: namely, two kinds of yeast, a nematode, a fruit fly, a toad, three different plants, and human and murine cells. This second edition of DNA Repair Protocols covers mammalian cells only and hence its new subtitle, Mammalian Systems. There are two reasons for this fresh emphasis, both of them pragmatic: to cater to the interests of what is now a largely mammalocentric DNA repair field, and to expedite editing and prod- tion of this volume. Although DNA Repair Protocols: Mammalian Systems is a smaller book than its predecessor, it actually contains a greater variety of methods. Fourteen of the book’s thirty-two chapters are entirely new and areas of redundancy present in the first edition have been eliminated here (for example, now just two chapters describe assays for nucleotide excision repair [NER], rather than seven). All eighteen returning chapters have been revised, many of them ext- sively. In order to maintain a coherent arrangement of topics, the four-part p- titioning seen in the first edition was dispensed with and chapters concerned with ionizing radiation damage and DNA strand breakage and repair were re- cated to near the front of the book. Finally, an abstract now heads each chapter.
Separation Methods In Microanalytical Systems
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Author : Jorg P. Kutter
language : en
Publisher: CRC Press
Release Date : 2005-09-09
Separation Methods In Microanalytical Systems written by Jorg P. Kutter and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-09 with Science categories.
Focusing on what has been one of the driving forces behind the development of lab-on-a-chip devices, Separation Methods in Microanalytical Systems explores the implementation, realization, and operation of separation techniques and related complex workflows on microfabricated devices. The book details the design, manufacture, and integration of diverse components needed to perform an entire analytical procedure on a single miniaturized device. This volume is valuable reference for scientists and engineers anticipating the demand for function-specific chemical separation systems in biomedical diagnostics, environmental monitoring, and drug discovery applications.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 2000-05
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05 with Cancer categories.