Myb Transcription Factors Their Role In Growth Differentiation And Disease
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Myb Transcription Factors Their Role In Growth Differentiation And Disease
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Author : Jon Frampton
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-13
Myb Transcription Factors Their Role In Growth Differentiation And Disease written by Jon Frampton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-13 with Medical categories.
This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.
Myb Transcription Factors
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Author : Jon Frampton
language : en
Publisher:
Release Date : 2014-09-01
Myb Transcription Factors written by Jon Frampton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with categories.
Transcription Factors
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Author : Katya Ravid
language : en
Publisher: John Wiley & Sons
Release Date : 2003-11-04
Transcription Factors written by Katya Ravid and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-04 with Science categories.
Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Oncogenes As Transcriptional Regulators
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Author : Moshe Yaniv
language : en
Publisher: Birkhäuser
Release Date : 2013-12-01
Oncogenes As Transcriptional Regulators written by Moshe Yaniv and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Science categories.
The intensive study of molecular events leading to cellular transformation in tissue culture or in intact organisms culminated in the identification of 100 or more genes that can be defined as oncogenes or tumor suppressor genes. Functionally, these genes can be divided into several classes, each involved in a different step in transmission of signals from the exterior of the cell to the nucleus. The first oncogenes to be biochemically character ized included membrane receptors for growth factors, growth factors themselves, protein kinases or small GTP binding proteins involved in signal transduction. Later, the development of techniques to study pro teins-DNA interaction in eucaryotes and the isolation and characterization of many promoter and enhancer sequences revealed that a number of the classical retroviral oncogenes were indeed transcription factors. In paral lel, the rapid progress in the identification and cloning of chromosomal translocations in human and animal malignancies and the increased reper toire of known transcription factors families revealed that many other transcription factors can playa critical role in cancer. A more recent devel opment concerns tumor suppressor genes. The realization that human tumors are frequently associated with a loss of function of one or several genes is also one of the landmarks of cancer research in the last 15 years. Again, as we will see below, some of these genes encode transcription factors. It is becoming increasingly difficult to cover in a single monograph all oncogenes and tumor suppressor genes.
The Paraoxonases Their Role In Disease Development And Xenobiotic Metabolism
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Author : Bharti Mackness
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-26
The Paraoxonases Their Role In Disease Development And Xenobiotic Metabolism written by Bharti Mackness and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-26 with Medical categories.
In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up-to-date, state-of-the-art review of current paraoxonase research. The book details a unique and novel enzyme whose physiological/pathological function(s) are just starting to be revealed.
Advances In Environmental Stress Biology And Important Agronomic Traits Improvement In Non Staple Crops
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Author : Meng Kou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-15
Advances In Environmental Stress Biology And Important Agronomic Traits Improvement In Non Staple Crops written by Meng Kou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-15 with Science categories.
Non-staple crops (sometimes known as underutilized, semidomesticated, orphan and/or forgotten crops) usually refer to under-researched grain and legume compared to staple crops, such as sweetpotato, buckwheat, millet, barley, pea, mung beans, and adzuki beans, which contain unique and beneficial nutrients that staple crops do not have. Combining them with staple foods is an important guarantee for a nutrition-balanced diet. With the deepening of research, the current research on non-staple crops has gradually started to create a wide range of materials, identify varieties and quality, improve yield, respond to environmental conditions and regulate growth and development. Therefore, it is an important research objective to improve the important agronomic traits of non-staple crops, including anthocyanins in sweetpotato, rutin in buckwheat, vitamins in millet, β-glucan in barley, etc. through both cultivation and molecular breeding methods and to create new germplasm resources with high yield and abundant nutrients. Recently, notable successes have been made using genomic-related approaches to uncover the genes responsible for important phenotypes in non-staple crops. The genetic basis of metabolomic divergence and domestication has been revealed in buckwheat, and the QTLs for controlling agronomic traits such as flesh color of sweetpotato have been obtained, however the function of related genes still needs further investigation. In addition, biotic and abiotic stresses in extreme climatic conditions change the yield and quality of crops by affecting the growth and development of crops and important metabolic regulation processes. Non-staple crops are often climate-resilient and grown in marginal regions with low-input conditions, including examples for tolerance of drought stress in cowpea and buckwheat, tolerance of heat in cassava and tolerance of barren in sweetpotato. Investigating the mechanism of their environmental adaptability would provide new insights for breeding of not only non-staple crops but also staple crops that are limited in the tolerance of a changing climate to ensure future food security. It is of great theoretical significance and practical application value to study the molecular regulatory network of non-staple crops under these stress conditions. • Using cultivation measures, plant growth regulators, fertilizers, and other methods to improve the environmental stress resistance and important agronomic traits in non-staple crops. • Revealing molecular mechanisms and regulatory network under all kinds of environmental stresses in non-major crops and improving stress tolerance through genetic engineering. • Identifying key regulatory genes of important agronomic traits in non- staple crops and improving molecular breeding methods.
Plant Transcription Factors
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Author : Vikas Srivastava
language : en
Publisher: Elsevier
Release Date : 2022-11-09
Plant Transcription Factors written by Vikas Srivastava and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-09 with Science categories.
Plant Transcription Factors: Contribution in Development, Metabolism, and Environmental Stress provides comprehensive coverage of plant TFs and their various functions, evaluating their crucial role in growth and development, signaling, stress management and other key plant processes. Sections cover the significance of plant TFs in functional genomics, the influence of phyto-hormones on the modulation of plant TFs, plant development and metabolism, including shoot development, flowering development and alkaloid biosynthesis. The book's final section reviews the role of TFs in various plant stresses, including temperature, water and heavy metal stress. Written by leading experts around the globe, this book is an essential read to researchers interested in plant signaling and plant genomics. Presents the latest advances in plant transcription factors and their functions Discusses the influence of phyto-hormones on the modulation of plant transcription factors Highlights the relationship between plant TFs and plant development
Nmr Metabolomics In Cancer Research
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Author : Miroslava Čuperlović-Culf
language : en
Publisher: Elsevier
Release Date : 2012-12-17
Nmr Metabolomics In Cancer Research written by Miroslava Čuperlović-Culf and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-17 with Medical categories.
The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types
Ras Family Gtpases
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Author : Channing Der
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-04-29
Ras Family Gtpases written by Channing Der and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-29 with Medical categories.
Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. This book features chapters contributed by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
Recent Advances In Polyphenol Research Volume 7
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Author : Jess Reed
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-19
Recent Advances In Polyphenol Research Volume 7 written by Jess Reed and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-19 with Science categories.
RECENT ADVANCES IN POLYPHENOL RESEARCH Plant polyphenols are secondary metabolites that constitute one of the most common and widespread groups of natural products. They are essential plant components for adaptation to the environment and possess a large and diverse range of biological functions that provide many benefits to both plants and humans. Polyphenols, from their structurally simplest forms to their oligo/polymeric versions (i.e. tannin and lignin), are phytoestrogens, plant pigments, antioxidants, and structural components of the plant cell wall. The interaction between tannins and proteins is involved in plant defense against predation, cause astringency in foods and beverages, and affect the nutritional and health properties of human and animal food plants. This seventh volume of the highly regarded Recent Advances in Polyphenol Research series is edited by Jess Dreher Reed, Victor Armando Pereira de Freitas, and Stéphane Quideau, and brings together chapters written by some of the leading experts working in the polyphenol sciences today. Topics covered include: Chemistry and physicochemistry Biosynthesis, genetics and metabolic engineering Roles in plants and ecosystems Food, nutrition and health Applied polyphenols Distilling the most recent and illuminating data available, this new volume is an invaluable resource for chemists, biochemists, plant scientists, pharmacognosists and pharmacologists, biologists, ecologists, food scientists and nutritionists.