Natural Products And Neuroprotection
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Natural Products And Neuroprotection
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Author : Cristina Angeloni
language : en
Publisher: MDPI
Release Date : 2020-06-17
Natural Products And Neuroprotection written by Cristina Angeloni and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Science categories.
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.
Natural Products And Neuroprotection
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Author : Cristina Angeloni
language : en
Publisher:
Release Date : 2020
Natural Products And Neuroprotection written by Cristina Angeloni and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.
Discovery And Development Of Neuroprotective Agents From Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: Elsevier
Release Date : 2017-05-18
Discovery And Development Of Neuroprotective Agents From Natural Products written by Goutam Brahmachari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-18 with Science categories.
Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
The Benefits Of Natural Products For Neurodegenerative Diseases
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Author : M. Mohamed Essa
language : en
Publisher: Springer
Release Date : 2016-09-20
The Benefits Of Natural Products For Neurodegenerative Diseases written by M. Mohamed Essa and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-20 with Medical categories.
Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
Neuroprotective Natural Products
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Author : Goutam Brahmachari
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-01
Neuroprotective Natural Products written by Goutam Brahmachari and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-01 with Medical categories.
Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.
Neuroprotection And Neurorestoration Natural Medicinal Products In Preventing And Ameliorating Cognitive Impairment
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Author : Jianxun Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-31
Neuroprotection And Neurorestoration Natural Medicinal Products In Preventing And Ameliorating Cognitive Impairment written by Jianxun Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-31 with Science categories.
The value and therapeutic potential of medicinal plants as molecular sources has been demonstrated throughout history and remains an important resource for identifying novel drug leads. A major asset in medicinal plant drug discovery is the presence of ethnopharmacological information that provides clues to the therapeutic efficacy of compounds in humans. With the coming of an aging society, neurodegenerative conditions have arguably become the most dreaded maladies of the elderly. The latest idea is that some aspects of the aging process can be reversed at a younger age if the brain is malleable. If this idea is realized, it may also be possible to slow or reverse neurodegeneration and cognitive impairment. Natural medicines display promising neuroprotective and neuroreparatived properties in neurological diseases.
Natural Products For Neurodegenerative Diseases
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Author : Yung Hou Wong
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2005
Natural Products For Neurodegenerative Diseases written by Yung Hou Wong and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Natural products categories.
Natural products have long been used for the relief of neurological symptoms, yet their mechanisms of action remain elusive. Recent investigations have started to unveil the complex molecular events associated with the therapeutic effects of natural products in neurodegenerative diseases. In this publication, leading experts share their perspectives and latest research findings on the roles of natural products in neuroprotection and neuronal regeneration. Multifunctional properties of constituents of botanicals and their derivatives are discussed to illustrate the possibilities towards the development of effective multitarget therapeutics. Researchers in the fields of neuroscience, molecular biology, alternative medicine and pharmacology will find that this issue provides a useful overview of the various mechanisms underlying the therapeutic effects of natural products in neurodegenerative diseases.
Neuroprotective Effects Of Phytochemicals In Neurological Disorders
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Author : Tahira Farooqui
language : en
Publisher: John Wiley & Sons
Release Date : 2017-01-03
Neuroprotective Effects Of Phytochemicals In Neurological Disorders written by Tahira Farooqui and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-03 with Medical categories.
Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
Lead Compounds From Medicinal Plants For The Treatment Of Neurodegenerative Diseases
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Author : Christophe Wiart
language : en
Publisher: Academic Press
Release Date : 2013-12-16
Lead Compounds From Medicinal Plants For The Treatment Of Neurodegenerative Diseases written by Christophe Wiart and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Medical categories.
Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration
Medicinal Herbs And Fungi
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Author : Dinesh Chandra Agrawal
language : en
Publisher: Springer Nature
Release Date : 2021-01-21
Medicinal Herbs And Fungi written by Dinesh Chandra Agrawal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-21 with Science categories.
The ever-rising increase in the consumption of medicinal herbs and its products and its exposure in the human population have generated concerns about the potential neurotoxicity of several new and existing botanicals. This book offers an accurate, relevant, and comprehensive coverage of a wide variety of medicinal herbs and fungi affecting the central and peripheral nervous system. It includes review articles that thoroughly describe the benefits and adverse effects of some of the most commonly used medicinal herbs and fungi, and the pathophysiological mechanisms underlying them. The book provides an all-inclusive overview of the diverse aspects of medicinal herbs and fungi related to neurotoxicity and/or neuroprotection, ranging from discussions of cellular and molecular processes and pathology to clinical aspects. The rich compilation brings together thorough and extensive research updates on the advances in the field. The chapters have been contributed by the experienced and eminent academicians, researchers, and scientists working in the field across the globe.