Neonatal Immunity
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Neonatal Immunity
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Author : Constantin Bona
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-05
Neonatal Immunity written by Constantin Bona and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-05 with Medical categories.
A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
Immunology Of The Neonate
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Author : G.Roberto Burgio
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunology Of The Neonate written by G.Roberto Burgio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Over the last few years, many new observations have profoundly changed our concepts of the immune competence of the newborn. For the immune system, as for other systems and functions, the neonatal age represents a crucial transition period. In fact the immune characteristics of the fetus are likely to result fro- or be conditioned by - several often contradictory physiological requirements. On the one hand, it would certainly be an advantage for the fetus to acquire a complete immunocompetence as soon as possible in order to be able to cope with the eventual transplacental passage of pathogenic microorganisms and possibly also in order to reject maternal cells occasionally crossing the placental nd barrier. This is actually what occurs, at least in part, during the 2 and Jfd month of gestation when the fetus begins to acquire his biological individuality and at the same time the role of a "biological ego" resulting from the attain ment by the immune system of the capacity to discriminate between self and nonself.
The Immunity Of The Human Foetus And Newborn Infant
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Author : Ivo Miler
language : en
Publisher: Springer
Release Date : 1983
The Immunity Of The Human Foetus And Newborn Infant written by Ivo Miler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Family & Relationships categories.
7 Introduction - what is ontogenesis? 9 Ontogenesis of immunity of the human foetus 12 Development of the cellular substrate of the immune system . . . . . . . 13 Development of the lymphatic system . . . . . . . . . . . . . . . . 14 Synthesis of immunologically active proteins - the complement components and immunoglobulins - in the foetal period 18 Complement components. . . . . . . . . . . . . 18 Immunoglobulin synthesis . . . . . . . . . . . . 23 B lymphocytes with surface membrane immunoglobulins 26 Transmission of antibodies ami immunoglobulins from mother to foetus 29 Transplacental transmission of specific antibodies . . . . . . . * 29 Transplacental transmission of immunoglobulins . . . . . . . . . 33 Physiological conditions for the transmission of immunoglobulins from mother to foetus . . . . . . . . . . . . . . . . . . . . . . . . . 36 Mechanism of transplacental transmission of IgG . . . . . . . . . . 39 Role of the Fc fragment of the IgG molecule and of cell receptors in the transplacental transmission of IgG . . . . . 42 Antibacterial mechanisms of the amniotic fluid . . . . . . . . . . . . 45 Ontogenesis of the foetus's cellular immunity . . . . . . . . . . . . 47 Incidence in the foetus of T lymphocytes forming spontaneous E rosettes 48 Functional activity of the T cell system . . . . . . . . . . . . . . . 49 Response offoetallymphocytes to phytohaemagglutinin (PHA) stimulation in vitro . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Proliferative response of foetal lymphocytes to stimulation by allogenic cells in mi. xed lymphocyte cultures . . . . . . . . . . . . . . . . 51 Effector activity of foetal lymphocytes - cytotoxicity . . . . . . . . 52 Chronological survey of the commencement of foetal immunocompetence 53 Immunity of the physiological neonate Natural (nonspecific) neonatal immunity . , . . . . . . . . . . . . . 61 Cellular factors of natural neonatal immunity. The function of poly morp- nuclear (PMN) leucocytes - the inflammatory reaction . . . . .
Reducing Neonatal Infectious Morbidity And Mortality Joining Up Our Thinking
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Author : Christine Elizabeth Jones
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-25
Reducing Neonatal Infectious Morbidity And Mortality Joining Up Our Thinking written by Christine Elizabeth Jones and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with categories.
The Neonatal Immune System A Unique Host Microbial Interface
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Author : Joseph M. Bliss
language : en
Publisher: Frontiers Media SA
Release Date : 2018-01-25
The Neonatal Immune System A Unique Host Microbial Interface written by Joseph M. Bliss and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-25 with categories.
Emerging from the protective environment of the uterus, the newborn is exposed to a myriad of microbes, and quickly establishes a complex microbiome that shapes the infant’s biology in ways that are only now beginning to come to light. Among these exposures are a number of potential pathogens. The host responses to these pathogens in the neonatal period are unique, reflecting a developing immune system even with delivery at term. Preterm infants are delivered at a time when host defense mechanisms are even less developed and therefore face additional risk. As such, the organisms that cause disease in this period are different from the pathogens that are common in other age groups, or the disease they cause manifests in more severe fashion. Developmental alterations in both innate and adaptive immune responses in neonates have been documented among many cell types and pathways over the last several decades. Contemporary insights into the human immune system and methodologies that allow an “omics” approach to these questions have continued to provide new information regarding the mechanisms that underlie the human neonate as an “immunocompromised host.” This Research Topic highlights studies related to this unique host-pathogen interface. Contributions include those related to the innate or adaptive immune system of neonates, their response to microbial colonization or infection, and/or the pathogenesis of microbes causing disease in neonates.
Immunology Of Milk And The Neonate
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Author : Jiri Mestecky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunology Of Milk And The Neonate written by Jiri Mestecky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the course of history, humans have attempted to interrupt the physiological and psychological bond formed between a nursing mother and her child by substituting breastfeeding with artificial formulas. A growing body of evidence indicates that breast milk, quite apart from its unsurpassed nutritive value, contains a large number of substances that protect the offspring from common infectious agents and allergens and promote the maturation of the gastrointestinal tract and the immune system. In addition to well described milk antibodies and soluble mediators of innate immunity, milk cells and pluripotent secreted factors - cytokines - are currently in the forefront of extensive research with respect to their importance in milk immunology. The purpose of this conference was to critically evaluate the current state of our knowledge concerning the protective role of immune agents found in milk, to provide up-to-date information of milk factors with respect to their role in the maturation of immunological defense systems in the neonate, and to reassess the importance of breastfeeding in the prevention of allergies in formula-fed infants. We hope that the work presented by international participants will prompt many new ideas and stimulate further research in this important area. This conference was sponsored primarily by the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. We would like to thank Drs. Sumner Yaffe and Delbert Dayton for their efforts with the organization, planning, and support of this conference.
Foetal And Neonatal Immunology
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Author : J. B. Solomon
language : en
Publisher:
Release Date : 1971
Foetal And Neonatal Immunology written by J. B. Solomon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Developmental immunology categories.
Neonatal Hematology
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Author : Pedro A. de Alarcón
language : en
Publisher: Cambridge University Press
Release Date : 2021-02-18
Neonatal Hematology written by Pedro A. de Alarcón and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-18 with Medical categories.
An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.
Neonatal Haematology And Immunology Ii
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Author : Marietta Xanthou
language : en
Publisher:
Release Date : 1993
Neonatal Haematology And Immunology Ii written by Marietta Xanthou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Family & Relationships categories.
Outlines the main topics on foetal and neonatal haematology and immunology. The authors propose methods to prevent and treat neonatal illnesses, including severe infections.
Neonatal Haematology And Immunology
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Author : Marietta Xanthou
language : en
Publisher:
Release Date : 1990
Neonatal Haematology And Immunology written by Marietta Xanthou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
This book outlines main topics on foetal and neonatal haematology and immunology, based on the most recent knowledge available. Top-specialists from all around the world describe the ontogeny of haemopoiesis and host-defence mechanisms as well as their development during the neonatal period. According to their most recent research findings the authors propose methods to prevent and treat important neonatal illnesses, like severe infections. This proceedings is an invaluable reference guide for those dealing with haematologic and immunologic deficiences during the perinatal period. Extensive photographs, tables and figures are included. Haematologists, immunologists and neonatologists will find this book an excellent reference for their work, while paediatricians, obstetricians, microbiologists, gastroenterologists, virologists, intensivistes neurologists and physiologists will also find it of great value.