Neuroimmune Circuits Drugs Of Abuse And Infectious Diseases


Neuroimmune Circuits Drugs Of Abuse And Infectious Diseases
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Neuroimmune Circuits Drugs Of Abuse And Infectious Diseases


Neuroimmune Circuits Drugs Of Abuse And Infectious Diseases
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Author : Herman Friedman
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11

Neuroimmune Circuits Drugs Of Abuse And Infectious Diseases written by Herman Friedman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.


Introduction and Perspectives This volume is based on the proceedings of the 7th annual symposium on the topic Neuroimmune Circuits, Infectious Diseases and Drugs of Abuse, Bethesda, Maryland, Oc- ber 7–9, 1999. This symposium, as in the past, focused on newer knowledge concerning the relationship between the immune and nervous systems with regards to the effects of drugs of abuse and infections, including AIDS, caused by the immunodeficiency virus. Presentations discussed the brain-immune axis from the viewpoint of drugs of abuse rather than from the subject of the brain or immunity alone. The major aim of this series of conferences has been to clarify the consequences of immunomodulation induced by drugs of abuse in regards to susceptibility and pathogenesis of infectious diseases, both in man and in various animal model systems. The recreational use of drugs of abuse such as morphine, cocaine, and marijuana by large numbers of individuals in this country and around the world has continued to arouse serious concerns about the consequences of use of such drugs, especially on the normal physiological responses of an individual, including immune responses. Much of the recent data accumulated by investigators show that drugs of abuse, especially opioids and cannabinoids, markedly alter immune responses in human populations as well as in experimental animals, both in vivo and in vitro.



Diabetes And Cardiovascular Disease


Diabetes And Cardiovascular Disease
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Author : Aubie Angel
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Diabetes And Cardiovascular Disease written by Aubie Angel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.



Immunoendocrinology In Health And Disease


Immunoendocrinology In Health And Disease
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Author : Vincent Geenen
language : en
Publisher: CRC Press
Release Date : 2004-08-30

Immunoendocrinology In Health And Disease written by Vincent Geenen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-30 with Medical categories.


One of the first comprehensive references dealing specifically with this new field of interdisciplinary research in medicine, Immunoendocrinology in Health and Disease offers a full scientific picture of where the immune and neuroendocrine systems intersect-placing current understanding of system components, mechanisms, and functions side by side w



The Neurology Of Aids


The Neurology Of Aids
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Author : Howard E. Gendelman
language : en
Publisher: Oxford University Press, USA
Release Date : 2005

The Neurology Of Aids written by Howard E. Gendelman and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.


The Neurology of AIDS is a compilation of works addressing six major aspects of nervous system disease that commonly follows HIV-1 infection. This includes basic science; clinical science; neuropathology; therapy; neuropsychiatric and prospectives of disease provided by patients.



Biological Reactive Intermediates Vi


Biological Reactive Intermediates Vi
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Author : Patrick M. Dansette
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Biological Reactive Intermediates Vi written by Patrick M. Dansette and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.



Bioactive Components Of Human Milk


Bioactive Components Of Human Milk
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Author : David S. Newburg
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Bioactive Components Of Human Milk written by David S. Newburg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


The major emphasis in this book is a compilation and definition of what is known about components of human milk, including glycoconjugates, that inhibit common pathogens of the infant. Also discussed are other bioactive constituents whose relevant biological roles are also beginning to be defined. Hormonal and cytokine activity, immunomodulating and autoinflammatory agents, xenobiotics, and conditionally essential nutrients in milk could have roles in the protection of the infant, but may also participate in digestive processes, maternal-infant communication, maturation of the gut, central nervous system, and other components of infant growth and development. Like the protective activities, these are discussed in terms of their presence in milk, structures, potential functions, and structure/function relationship. Components whose role is nutritional support during early development of the infant are also included.



Intractable Seizures


Intractable Seizures
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Author : W. McIntyre Burnham
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Intractable Seizures written by W. McIntyre Burnham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.



Genome Instability In Cancer Development


Genome Instability In Cancer Development
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Author : Erich A. Nigg
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-14

Genome Instability In Cancer Development written by Erich A. Nigg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-14 with Medical categories.


Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.



Noninvasive Assessment Of Trabecular Bone Architecture And The Competence Of Bone


Noninvasive Assessment Of Trabecular Bone Architecture And The Competence Of Bone
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Author : Sharmila Majumdar
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Noninvasive Assessment Of Trabecular Bone Architecture And The Competence Of Bone written by Sharmila Majumdar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


The study of bone microarchitecture is flourishing because of a recent shift in perspective that has taken researchers beyond utilizing bone mineral density as the primary source of information about certain matters related to bone. In the area of osteoporosis and skeletal changes, bone mineral density (BMD) is widely used for screening, monitoring and assessing therapeutic efficacy, and yet, it is currently accepted that BMD does not fully explain the pathogenesis of osteoporosis, the process of aging, nor mechanisms of therapeutic efficacy. In this context, the study of trabecular microarchitecture has much to contribute. The emerging field of trabecular microarchitecture, however, is diverse, inter-disciplinary and encompasses many different imaging modalities. This volume represents a compilation of papers from world-renowned researchers, reflecting the most current research in the area of noninvasive assessment of trabecular microcarchitecture. This varied research applies sophisticated imaging tools to questions of bone biomechanics at both the basic science and clinical levels. The authors' works range from review articles and research articles to works in progress. Taken together, they offer a foray into the "state of the art" of investigating bone at its most basic levels.



Hypoxia


Hypoxia
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Author : Robert C. Roach
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17

Hypoxia written by Robert C. Roach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.


Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.