Neuronal Guidance
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Neuronal Guidance
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Author : Marc Tessier-Lavigne
language : en
Publisher:
Release Date : 2011
Neuronal Guidance written by Marc Tessier-Lavigne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
During the development of the brain growing nerves send out neuronal processes (axons and dendrites) that connect them to other nerve cells, sensory organs, and muscle tissue. Correct targeting of these is the basis for wiring of the entire nervous system and depends on attractive and repulsive molecular cues that guide the developing neurons to the appropriate destination. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the mechanisms underlying neuronal guidance and branching and their roles in the development and function of the nervous system. The contributors examine the major guidance cues and their receptors, the intracellular signaling pathways they activate, and their function in the context of important phenomena such as laminar organization and dendrite spacing. Other chapters consider the roles of guidance cues in development of neuronal circuits dedicated to the processing of particular sensory stimuli, such as the visual and olfactory systems. In addition, they cover the roles played by guidance cues and their receptors in neuronal regeneration and human genetic disorders, revealing important clinical implications of work in this field. The book also contains chapters discussing the function of guidance molecules in other processes, such as neuronal cell body migration, axon pruning, and regulation of neuronal cell death. In addition, it explores their roles outside the nervous system for example, in development of the vasculature. This volume is thus of general interest to cell and developmental biologists, as well as all neurobiologists interested in how the nervous system develops and functions.
Axon Growth And Guidance
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Author : Dominique Bagnard
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-10
Axon Growth And Guidance written by Dominique Bagnard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-10 with Medical categories.
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Guidance Cues In The Developing Brain
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Author : Ivica Kostovic
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Guidance Cues In The Developing Brain written by Ivica Kostovic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Many complex molecular interactions are involved in the development of the mammalian brain. Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment. In addition, most guidance cue molecules are also involved in plasticity, damage repair and regeneration in the adult brain. This volume reviews current knowledge on major classes of molecules involved in: guidance of growing axons; tau proteins involved in the establishment of axonal polarity, outgrowth and contact recognition; gangliosides and lectins involved in neuronal migration, neurite outgrowth and contact recognition; and myelin molecules that inhibit nerve regeneration.
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections
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Author : L. Izzi
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-06
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections written by L. Izzi and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Medical categories.
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections
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Author : F. Beaubien
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-06
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections written by F. Beaubien and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Medical categories.
The Neuronal Guidance Molecules Reelin And Flrt2 Orchestrate Neurovascular Development In The Central Nervous System
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Author : Cecília Llaó Cid
language : en
Publisher:
Release Date : 2021
The Neuronal Guidance Molecules Reelin And Flrt2 Orchestrate Neurovascular Development In The Central Nervous System written by Cecília Llaó Cid and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Axon Guidance Signaling In C Elegans Motor Neurons And Its Application To Understanding Neurological Disorders
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Author : Shih-Yu Chen
language : en
Publisher:
Release Date : 2012
Axon Guidance Signaling In C Elegans Motor Neurons And Its Application To Understanding Neurological Disorders written by Shih-Yu Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The hallmark of the nervous system is its ability to process information. This unique feature relies on proper establishment of the entire network of neuronal connections. Axon guidance is one of the early developmental processes that are essential for establishing functional neuronal connections throughout the nervous system. The goal of my work is to understand the molecular mechanisms of axon guidance and its implications in human disorders. During axon guidance the growing axon has to constantly regulate its receptors in order to properly sense concentration differences across a gradient set by a guidance cue. My results showed that the axon guidance signaling molecule MAX-1 is SUMOylated by its interacting partner GEI-17 and regulates UNC-5 receptor through APB-3 containing AP-3 complex in Caenorhabditis elegans motor neurons. The data collected from my studies lead to a model that MAX-1 and APB-3 signaling pathway modulate the dynamic trafficking of axon guidance receptor UNC-5 when axon is guided across a concentration gradient. Defects in neuronal connectivity of the brain are well documented among schizophrenia patients. Although the schizophrenia susceptibility gene Disrupted-in-Schizophrenia 1 (DISC1) has been implicated in various neurodevelopmental processes, its role in regulating axonal connections remains elusive. Using a relatively simple and well-characterized Caenorhabditis elegans motor neurons system, I established a heterologous DISC1 transgenic model to investigate whether DISC1 regulates axon guidance during development. My results revealed a previously unknown function of DISC1 to shape axonal connectivity in the developing nervous system by exploiting the TRIO-RAC-PAK signaling pathway.
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections
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Author : J. Falk
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-06
Comprehensive Developmental Neuroscience Cellular Migration And Formation Of Neuronal Connections written by J. Falk and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Medical categories.
Neuronal Mechanics And Transport
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Author : Daniel M. Suter
language : en
Publisher: Frontiers Media SA
Release Date : 2016-05-26
Neuronal Mechanics And Transport written by Daniel M. Suter and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-26 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Understanding the underlying mechanisms of how axons and dendrites develop is a fundamental problem in neuroscience and a main goal of research on nervous system development and regeneration. Previous studies have provided a tremendous amount of information on signaling and cytoskeletal proteins regulating axonal and dendritic growth and guidance. However, relatively little is known about the relative contribution and role of cytoskeletal dynamics, transport of organelles and cytoskeletal components, and force generation to axonal elongation. Advancing the knowledge of these biomechanical processes is critical to better understand the development of the nervous system, the pathological progression of neurodegenerative diseases, acute traumatic injury, and for designing novel approaches to promote neuronal regeneration following disease, stroke, or trauma. Mechanical properties and forces shape the development of the nervous system from the cellular up to the organ level. Recent advances in quantitative live cell imaging, biophysical, and nanotechnological methods such as traction force microscopy, optical tweezers, and atomic force microscopy have enabled researchers to gain better insights into how cytoskeletal dynamics and motor-driven transport, membrane-dynamics, adhesion, and substrate rigidity influence axonal elongation. Given the complexity and mechanical nature of this problem, mathematical modeling contributes significantly to our understanding of neuronal mechanics. Nonetheless, there has been limited direct interaction and discussions between experimentalists and theoreticians in this research area. The purpose of this Frontiers Research Topic is to highlight exciting, and important work that is currently developing in the fields of neuronal cell biology, neuronal mechanics, intracellular transport, and mathematical modeling in the form of primary research articles, reviews, perspectives, and commentaries.
Mechanisms Of Axon Guidance And Neuronal Asymmetry In The Nematode Caenorhabditis Elegans
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Author : Yanli Hou
language : en
Publisher:
Release Date : 2007
Mechanisms Of Axon Guidance And Neuronal Asymmetry In The Nematode Caenorhabditis Elegans written by Yanli Hou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.