Neuronal Network Dynamics In 2d And 3d In Vitro Neuroengineered Systems
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Stem Cell And Tissue Engineering
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Author : Song Li
language : en
Publisher: World Scientific
Release Date : 2011-01-14
Stem Cell And Tissue Engineering written by Song Li and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-14 with Science categories.
Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.
Inorganic Nanoparticles
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Author : Claudia Altavilla
language : en
Publisher: CRC Press
Release Date : 2017-12-19
Inorganic Nanoparticles written by Claudia Altavilla and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-19 with Technology & Engineering categories.
Among the various nanomaterials, inorganic nanoparticles are extremely important in modern technologies. They can be easily and cheaply synthesized and mass produced, and for this reason, they can also be more readily integrated into applications. Inorganic Nanoparticles: Synthesis, Applications, and Perspectives presents an overview of these special materials and explores the myriad ways in which they are used. It addresses a wide range of topics, including: Application of nanoparticles in magnetic storage media Use of metal and oxide nanoparticles to improve performance of oxide thin films as conducting media in commercial gas and vapor sensors Advances in semiconductors for light-emitting devices and other areas related to the energy sector, such as solar energy and energy storage devices (fuel cells, rechargeable batteries, etc.) The expanding role of nanosized particles in the field of catalysis, art conservation, and biomedicine The book’s contributors address the growing global interest in the application of inorganic nanoparticles in various technological sectors. Discussing advances in materials, device fabrication, and large-scale production—all of which are urgently required to reduce global energy demands—they cover innovations in areas such as solid-state lighting, detailing how it still offers higher efficiency but higher costs, compared to conventional lighting. They also address the impact of nanotechnology in the biomedical field, focusing on topics such as quantum dots for bioimaging, nanoparticle-based cancer therapy, drug delivery, antibacterial agents, and more. Fills the informational gap on the wide range of applications for inorganic nanoparticles in areas including biomedicine, electronics, storage media, conservation of cultural heritage, optics, textiles, and cosmetics Assembling work from an array of experts at the top of their respective fields, this book delivers a useful analysis of the vast scope of existing and potential applications for inorganic nanoparticles. Versatile as either a professional research resource or textbook, this effective tool elucidates fundamentals and current advances associated with design, characterization, and application development of this promising and ever-evolving device.
Neuronal Network Dynamics In 2d And 3d In Vitro Neuroengineered Systems
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Author : Monica Frega
language : en
Publisher: Springer
Release Date : 2016-03-01
Neuronal Network Dynamics In 2d And 3d In Vitro Neuroengineered Systems written by Monica Frega and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-01 with Technology & Engineering categories.
The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.
Nanobioengineering
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Author : Bhupinder Singh
language : en
Publisher: CRC Press
Release Date : 2018-11-02
Nanobioengineering written by Bhupinder Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-02 with Science categories.
The objective of this book is to provide the fundamental comprehension of a broad range of topics in an integrated volume such that readership hailing from diverse disciplines can rapidly acquire the necessary background for applying it in pertinent research and development field.
Introductory Bioelectronics
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Author : Ronald R. Pethig
language : en
Publisher: John Wiley & Sons
Release Date : 2012-08-22
Introductory Bioelectronics written by Ronald R. Pethig and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-22 with Science categories.
Bioelectronics is a rich field of research involving the application of electronics engineering principles to biology, medicine, and the health sciences. With its interdisciplinary nature, bioelectronics spans state-of-the-art research at the interface between the life sciences, engineering and physical sciences. Introductory Bioelectronics offers a concise overview of the field and teaches the fundamentals of biochemical, biophysical, electrical, and physiological concepts relevant to bioelectronics. It is the first book to bring together these various topics, and to explain the basic theory and practical applications at an introductory level. The authors describe and contextualise the science by examining recent research and commercial applications. They also cover the design methods and forms of instrumentation that are required in the application of bioelectronics technology. The result is a unique book with the following key features: an interdisciplinary approach, which develops theory through practical examples and clinical applications, and delivers the necessary biological knowledge from an electronic engineer’s perspective a problem section in each chapter that readers can use for self-assessment, with model answers given at the end of the book along with references to key scientific publications discussions of new developments in the bioelectronics and biosensors fields, such as microfluidic devices and nanotechnology Supplying the tools to succeed, this text is the best resource for engineering and physical sciences students in bioelectronics, biomedical engineering and micro/nano-engineering. Not only that, it is also a resource for researchers without formal training in biology, who are entering PhD programmes or working on industrial projects in these areas.
Triboelectric Nanogenerators
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Author : Yunlong Zi
language : en
Publisher: John Wiley & Sons
Release Date : 2025-06-16
Triboelectric Nanogenerators written by Yunlong Zi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-16 with Technology & Engineering categories.
Comprehensive resource on the fundamentals, recent research developments, and applications of triboelectric nanogenerators (TENGs) Triboelectric Nanogenerators delivers a comprehensive overview of a lightweight, low cost, and high-efficiency sustainable mechanical energy harvesting technique that draws from the ambient environment and has high output and extremely flexible structural designs. The book starts with an introduction on triboelectric nanogenerator technology, then continues to discuss the latest fundamental studies about TENGs, including models of triboelectric effect, the discharge effect, and standardized evaluation. The next part explains new output performance promotion of TENGs for power generation applications, including output promotion through multiple methods, as well as power management and effective energy storage. The last part explores new concepts inspired by the field of TENGs, including applications in sensing, actuation, data science, artificial intelligence (AI), the Internet of Things (IoT), and smart cities. Written by a team of highly qualified academics with significant research experience in the field, Triboelectric Nanogenerators includes information on: Triboelectric charge generation and discharge, highlighting how electrostatic energy is often wasted Energy potential of TENGs in comparison to other sources such as lithium-ion batteries and other types of batteries Methods to promote and configure output performance, such as through gas environments, liquid-solid interfaces, and electromechanical structures High-voltage output from TENGs and its potential for new applications in areas such as breakdown charge triggering, electrospraying, field emissions, and others Triboelectric Nanogenerators is an essential reference for scientists, engineers, students, and professionals in related fields seeking to understand this exciting energy harvesting technique and gain all of the knowledge needed to help further progress in the field.
Converging Technologies For Improving Human Performance
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Author : Mihail C. Roco
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Converging Technologies For Improving Human Performance written by Mihail C. Roco and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Technology & Engineering categories.
M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
Advanced 3d Printed Systems And Nanosystems For Drug Delivery And Tissue Engineering
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Author : Lisa C. du Toit
language : en
Publisher: Elsevier
Release Date : 2020-03-08
Advanced 3d Printed Systems And Nanosystems For Drug Delivery And Tissue Engineering written by Lisa C. du Toit and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-08 with Technology & Engineering categories.
Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. - Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient - Explores the current generation of nanostructured 3D printed medical devices - Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals
Optical Fiber Technology And Applications Recent Advances
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Author : Mario F. S. Ferreira
language : en
Publisher: IOP Publishing Limited
Release Date : 2021-08-11
Optical Fiber Technology And Applications Recent Advances written by Mario F. S. Ferreira and has been published by IOP Publishing Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-11 with Science categories.
Optical Fiber Technology and Applications: Recent Advances, comprised of 10 chapters written by leading experts in the field, documents the cutting-edge work of new material composition and waveguide design-based specialty optical fibers and their photonic devices. Highlighting the most recent progress and trends in optical fiber technology, this book covers important topics such as specialty optical fibers, optical amplifiers, radiation dosimetry, borosilicate glass, radiation effect, fiber optic temperature sensors, pulsed fiber laser, non-linear fiber optics, solitons, supercontinuum generation, and fiber-optic-based 5G networks. Solely devoted to the most recent achievements in the development of different varieties of specialty optical fibers, this book serves as a universal resource for future development in the field while providing students, researchers, and technology managers with valuable, timely, and unbiased information on the subject. Key Features Up-to-date overview of optical fiber materials and their wide applications. Broad scope with insights from experts in the field. Serves as a universal resource for future development in the field while providing students, researchers, and technology managers with valuable, timely, and unbiased information on the subject.
Dynamics And Effective Connectivity In Bi And Three Dimensional Neuronal Cultures
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Author : Estefanía Estévez Priego
language : en
Publisher:
Release Date : 2020
Dynamics And Effective Connectivity In Bi And Three Dimensional Neuronal Cultures written by Estefanía Estévez Priego and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
"This thesis was part of the European consortium MESOBRAIN, a team of 5 organizations that joined efforts in nanofabrication, cell culturing, imaging and data analysis to build tailored human 3D networks. The thesis timing was limited to 3 years, and several of the resources needed for its development were built from scratch. The main objective of this Ph.D. thesis was to explore complex characteristics of cortical neuronal cultures in terms of effective connectivity and exhaustive network analyses. This objective comprised four research lines: (i) The evaluation of neuronal network resilience and emerging plasticity mechanisms, (ii) the characterization of functional development to underline crucial timepoints in healthy neuronal networks, (iii) the study of 3D network interactions of neurons embedded inside an ECM--like environment, and (iv) the design, construction and viability inspection of neurons seeded on tiny 3D nanoprinted solid scaffold structures as a first step towards recreating cortical columns in vitro.For these multiple lines, we used either primary rat cultures (i,iii,iv) or human--derived neurons (ii). The former group corresponds to cultures with long established protocols that have been thoroughly studied in the field. The latter group corresponds to human neurons derived from iPSCs, a relatively novel model with promising and thrilling applications in regenerative medicine. Despite the increasing use of stem cells in neuroscience, complex systems and medicine, they still lack a thorough exploration in terms of neuronal and circuit formation as well as the properties of the emergent activity patterns. With either primary or stem cells, we explored the formation of neuronal circuits in 2D and 3D, characterized the effective connectivity and rendered a number of network traits. This Thesis combines experiments of highly difficult implementation with detailed data analysis. It was necessary to develop brand new protocols for culturing 3D neuronal networks and for human-derived neurons, the use of different microscopy setups the programming of object detection and tracking software and advance the analysis toolbox of calcium fluorescence data. First, resilience experiments on primary clustered neuronal cultures consisted on progressive perturbations through chemical receptor antagonists. This study represents an inspiring numerical--experimental model to comprehend the impact of plasticity mechanisms in the spontaneous activity of neuronal circuits. The results showed that, upon progressive connectivity blockade through chemical receptors' antagonists, only--excitatory neuronal networks displayed a surprising hyper--efficiency (HE) state for early--onset doses. As plasticity mechanisms influence the response of effective connectivity in the presence of perturbations, these compensatory mechanisms, usually disregarded, must be included in biological modeling as accurately as possible. Otherwise, episodes of functional rewiring and synaptic strengthening could mask important phenomena during experiments that alter channel communication. A simple algorithm that hypothesized an effective synaptic scaling was able to capture the hyper--efficiency state seen in experimental data, while percolation models wrongly predicted a progressive decay.The second research line was a sum of engineering efforts within the MESOBRAIN consortium, the European adventure to build 3D neuronal cultures embedded in hydrogels and with the presence of scaffolds. After several months of biomaterials testing, the candidate D--Clear resulted suitable for the construction of scaffolds, both with primary rat cells and hiPSCs, due to its good optical properties, manageability and biocompatibility. To our knowledge, D--Clear was never used before outside the orthodontic field and could provide a new catalogue of interesting designs for support and guidance of neuronal assemblies. Using this material, we developed a series of designs to offer support and guidance to cortical neurons in a 3D platform.The third research line focused on the study of neuronal development and cell-to-cell interactions in a semi-synthetic hydrogel that resembles the extracellular matrix of the brain. These hydrogel cultures keep the advantages of in vitro models while achieving an effective connectivity and architecture closer to in vivo. Finally, the fourth line of research applied cortical neurons from human-derived pluripotent stem cells to study key developmental stages and characterize the healthy maturation of these cells in vitro. As this technology has tremendous potential for regenerative medicine and to model neuronal diseases, it is urgent to consolidate the capacity of these human neuronal networks to reproduce efficient activity patterns of healthy patients, and explore the differences against the results obtained with animal models." -- TDX.