Neuronal Nicotinic Acetylcholine Receptors In The Human Thalamus And Related Brain Areas In Health And Disease
DOWNLOAD
Download Neuronal Nicotinic Acetylcholine Receptors In The Human Thalamus And Related Brain Areas In Health And Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Neuronal Nicotinic Acetylcholine Receptors In The Human Thalamus And Related Brain Areas In Health And Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Neuronal Nicotinic Acetylcholine Receptors In The Human Thalamus And Related Brain Areas In Health And Disease
DOWNLOAD
Author : Melissa Ray
language : en
Publisher:
Release Date : 2005
Neuronal Nicotinic Acetylcholine Receptors In The Human Thalamus And Related Brain Areas In Health And Disease written by Melissa Ray and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Nicotinic Acetylcholine Receptors In Health And Disease
DOWNLOAD
Author : R. Thomas Boyd
language : en
Publisher: Academic Press
Release Date : 2023-03-14
Nicotinic Acetylcholine Receptors In Health And Disease written by R. Thomas Boyd and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders. Describes the roles, expression and function of nicotinic receptors Includes receptor involvement, both inside and outside the nervous system Details nicotinic receptor involvement in Alzheimer’s, Parkinson’s, Cancer, Schizophrenia, and more Emphasizes future treatment prospects of disorders via modulation of nAChR signaling
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection
DOWNLOAD
Author : Akinori Akaike
language : en
Publisher: Springer
Release Date : 2018-04-04
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection written by Akinori Akaike and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-04 with Medical categories.
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
Acetylcholine In The Cerebral Cortex
DOWNLOAD
Author : L. Descarries
language : en
Publisher: Elsevier
Release Date : 2004
Acetylcholine In The Cerebral Cortex written by L. Descarries and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Comprehensive exposé, by leading neuroscientists, of current knowledge on the neurotransmitter acetylcholine in the cerebral cortex. All aspects of the subject are covered, from its most elementary, at the molecular and cellular levels, to its systemic and holistic implications, including its role in cognition and involvement in human diseases and therapeutics. The twenty-two chapters are grouped under four main headings : I. Functional Morphology of the Acetylcholine Innervation in Cerebral Cortex (Including Hippocampus); II. Modes of Action of Acetylcholine in the Cerebral Cortex; III. Cortical Properties and Functions Modulated by Acetylcholine, and IV. Clinical, Pathological and Therapeutic Implications. This broad perspective updates the reader on recent advances and future trends in the study of a major neuromodulatory system in brain.
Nicotinic Acetylcholine Receptors In The Nervous System
DOWNLOAD
Author : Francesco Clementi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Nicotinic Acetylcholine Receptors In The Nervous System written by Francesco Clementi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled by acetylcholine. It is a key molecule in the chemical communication between nerve cells and between nerve cell and muscle. The structure and function of muscular nicotinic receptors have been unraveled in recent years and its beauty and mysteries were reviewed in the Santorini NATO ARW organized by Dr. Maelicke in 1986. The neat, linear structure of this molecule and its conservation throughout evolution, from bacteria to humans, have led to the suggestion that it has reached the optimal structure for performing its function. But when scientists began to look at the nicotinic receptor in the nervous system, they found several surprises. From the beginning, pharmacological and physiological experiments, have made it clear that the functional characteristics of neuronal nicotinic receptors are substantially different from those of muscle receptors. Furthermore, recent sophisticated techniques such as patch clamp and gene cloning have revealed that the nicotinic receptor in the nervous system is not a single molecule but (although there are some important exceptions) a large family of similar molecules, which have in common the property of binding nicotinic agonists or antagonists. Over the last few years, the physiological implications of nicotinic receptors have been reevaluated on the basis of more precise behavioural and pharmacological techniques. Moreover, the involvement of nicotinic receptors in degenerative pathologies of the eNS, such as Parkinson's and Alzheimer's disease, has also been discovered very recently.
Nicotinic Receptors
DOWNLOAD
Author : Robin A.J. Lester
language : en
Publisher: Springer
Release Date : 2014-11-11
Nicotinic Receptors written by Robin A.J. Lester and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-11 with Medical categories.
A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.
Neuronal Nicotinic Receptors
DOWNLOAD
Author : Stephen P. Arneric
language : en
Publisher: Wiley-Liss
Release Date : 1999
Neuronal Nicotinic Receptors written by Stephen P. Arneric and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities Edited by Stephen P. Arneric and Jorge D. Brioni Nicotine's efficacy in the treatment of pain and anxiolysis, and its usefulness as a memory enhancer, have been suspected for many years, but research into the molecular biology of nicotinic acetylcholine receptors (nAChRs) traditionally has focused on smoking cessation. Now, thanks to recent technological advances in the molecular biology and electrophysiology of nAChRs, an abundance of evidence has emerged in support of nAChR ligands in the treatment of a range of CNS disorders, including Alzheimer's disease, Parkinson's disease, neuropathic pain, attention deficit disorder, and depression. Featuring contributions from an international team of experts in the field, this volume provides researchers and clinicians with a comprehensive review of nAChRs, their molecular biology, pharmacology, and clinical implications. Moving from the molecular to the clinical levels, the authors explore the latest developments in all areas of nAChR research, including: Molecular biology and biochemistry of nAChRs The physiological roles of nAChRs Pharmacokinetics of nicotine-like alkaloids Recent breakthroughs and emerging trends in nAChR medicinal chemistry Current and emerging therapeutic applications of novel nAChR ligands. A timely, authoritative review of basic research into nAChRs and their role in the development of new therapeutic strategies in the treatment of a range of various CNS diseases, Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities is required reading for neuroscientists, pharmacologists, medicinal chemists, biological psychiatrists, and psychopharmacologists.
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection
DOWNLOAD
Author : Shun Shimohama
language : en
Publisher:
Release Date : 2020-10-08
Nicotinic Acetylcholine Receptor Signaling In Neuroprotection written by Shun Shimohama and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
The Mechanisms And Pharmacology Of Neuronal Nicotinic Acetylcholine Receptors In The Central Nervous System
DOWNLOAD
Author : Bopanna I. Kalappa
language : en
Publisher:
Release Date : 2012
The Mechanisms And Pharmacology Of Neuronal Nicotinic Acetylcholine Receptors In The Central Nervous System written by Bopanna I. Kalappa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Neuronal nicotinic acetylcholine receptors (nAChRs) are key players in both cognitive and autonomic processes. In the cognitive domains of the brain, destruction of cholinergic inputs or disruption of nAChR function result in cognitive deficits as observed in Alzheimer's disease, schizophrenia, brain trauma and aging. By contrast, moderate activation of nAChRs supports neuroprotection and improves cognitive functions. In addition, neuronal nAChRs are also expressed in important autonomic centers such as the nucleus of the solitary tract (NTS) and the dorsal motor nucleus of the vagus (DMV) that support autonomic visceral reflexes and homeostasis. In this study, the underlying mechanisms of nAChR activation and its pharmacology were investigated in the hippocampus and the NTS, critical brain regions supporting cognitive and autonomic functions, respectively. Collectively, these studies may help in developing new therapeutic strategies to selectively target nAChR-associated pathways that support cognitive and autonomic functions in health and disease.
Neuronal Nicotinic Receptors
DOWNLOAD
Author : F. Clementi
language : en
Publisher: Springer
Release Date : 2012-01-19
Neuronal Nicotinic Receptors written by F. Clementi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-19 with Medical categories.
Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.