Neuropharmacology Of Cyclic Nucleotides
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Neuropharmacology Of Cyclic Nucleotides
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Author :
language : en
Publisher:
Release Date : 1977
Neuropharmacology Of Cyclic Nucleotides written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Neuropharmacology Of Cyclic Nucleotides
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Author : Gene C. Palmer
language : en
Publisher: Urban & Schwarzenberg
Release Date : 1979
Neuropharmacology Of Cyclic Nucleotides written by Gene C. Palmer and has been published by Urban & Schwarzenberg this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.
Neuropharmacology Of Cyclic Nucleotides
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Author : Gene C. Palmer
language : en
Publisher:
Release Date : 1979
Neuropharmacology Of Cyclic Nucleotides written by Gene C. Palmer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
Cyclic Nucleotides
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Author : P. D. Kebabian
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides written by P. D. Kebabian and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cyclic nucleotides are intimately involved in the consequences of either stimulation or blockade of receptors; therefore, an understanding of the biochemistry of cyclic nucleotides ought to be important for pharmacologists. Pharmacology is a science that among other things investigates chemical compounds that affect the physiology of cells, tissues and organs. Frequently pharmacologists account for the effect of low concentrations of a drug upon a tissue by invoking the presence of a receptor upon the surface of the cell. Traditional pharmacologists excelled at identifying and classifying the properties of receptors. A. J. CLARK'S monograph in the earlier series of the Handbook of Experimental Pharmacology (CLARK 1937) summarized the mathematics underlying the traditional pharmacological approach towards receptors. By its nature, however, classic pharmacology provided little useful information about the intracellular events occurring as a consequence of occupying a receptor; for example, ALQUIST (1948) identified the beta-adrenocep tor, but he did not provide any insight into how stimulation of the receptor produces tissue-specific physiological responses. The discovery of cyclic AMP by RALL and SUTHERLAND (see RALL, Vol. I) led to biochemical investigations of many different receptors (including ALQUIST'S beta-adrenoceptor) that share a cyclic nucleotide as a common factor in the biochemical mechanisms that translate the occupancy of receptors into physiological effects. Ten years ago, in the introduction to their monograph on cyclic nucleotides, ROBISON et al. (1971) commented on the rapid growth of interest in cyclic nucleotides over the preceding years.
Cyclic Nucleotides In The Nervous System
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Author : John Daly
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides In The Nervous System written by John Daly and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
Cyclic Nucleotides And Therapeutic Perspectives
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Author : G. Cehovic
language : en
Publisher: Pergamon
Release Date : 1979
Cyclic Nucleotides And Therapeutic Perspectives written by G. Cehovic and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.
Cyclic Nucleotides
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Author : J W Kebabian
language : en
Publisher:
Release Date : 1982-03-01
Cyclic Nucleotides written by J W Kebabian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-03-01 with categories.
Non Canonical Cyclic Nucleotides
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Author : Roland Seifert
language : en
Publisher: Springer
Release Date : 2017-04-28
Non Canonical Cyclic Nucleotides written by Roland Seifert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-28 with Medical categories.
The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.
The Biochemical Basis Of Neuropharmacology
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Author : Jack R. Cooper
language : en
Publisher: Oxford University Press, USA
Release Date : 1978
The Biochemical Basis Of Neuropharmacology written by Jack R. Cooper and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Autonomic drugs categories.
This classic text gives a uniquely lucid and lively view of neurotransmitters, their role in nervous system function, and their involvement in the mechanisms of psychiatric drug action. For three decades it has served as an essential guide for students of neuroscience and psychopharmacology, residents in psychiatry and neurology, and clinicians and scientists. Both authoriative and very readable, it has been thoroughly updated for each edition. In the 8th Edition more space is devoted to clinical examples, subclasses of receptors that provide targets for new drugs, molecular genetics, the major problem of drug delivery to the brain, and the growing recognition of nicotin receptors in the brain and their possible involvement in Alxheimer's and Parkinson's diseases. In addition, the book's format has been enlarged and a second color added to many of the illustrations.
Cholinergic Mechanisms And Psychopharmacology
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Author : D. Jenden
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Cholinergic Mechanisms And Psychopharmacology written by D. Jenden and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Psychology categories.
This volume represents a collection of papers which were contributed by participants at a Symposium for Cholinergic Mechanisms and Psycho pharmacology, held in La Jolla, California on March 28-30, 1977. The were chosen to emphasize areas in which there has been substantial topics progress in the past 2-3 years and fall into seven major groups dealingwith: cholinergiC receptors; chemistry, histochemistry and enzymology; cyclic nucleotides and cholinergiC mechanisms; storage, compartmentation and release of acetylcholine; regulatory mechanisms in acetylcholine metab olism; modulation of acetylcholine metabolism; and behavioral and clin ical manifestations of cholinergiC function and dysfunction. Each group contains one or more reviews and a number of shorter contributions de scribing current work. This symposium was the third in a series of which the first two were held in Skokloster, Sweden in 1970 and Boldern, Switzerland in 1974. The Proceedings of the meetings indicate a rapid development of knowledge of cholinergiC mechanisms which for many years lagged behind that of other neurotransmitters and neuroregulators. The inclusion of a large section in the present volume dealing with clinical manifestations of cholinergiC dysfunction reflects one of the most important trends in current research on cholinergiC mechanisms, namely the close inter-relationship and mutual support of basic science and clinical investigation. I hope that this volume will be of value to all those whose work relates to cholinergiC function, at both basic and clinicalleve18, and will continue to stimulate the vigorous exchange of ideas which was such a prominent feature of the Symposium.