Neuroscience Biomarkers And Biosignatures


Neuroscience Biomarkers And Biosignatures
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Neuroscience Biomarkers And Biosignatures


Neuroscience Biomarkers And Biosignatures
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2008-01-08

Neuroscience Biomarkers And Biosignatures written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Medical categories.


Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.



Biomarkers Of Neuroinflammation


Biomarkers Of Neuroinflammation
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2018-03-16

Biomarkers Of Neuroinflammation written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-16 with Medical categories.


Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.



Biomarkers In Alzheimer S Disease


Biomarkers In Alzheimer S Disease
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Author : Tapan Khan
language : en
Publisher: Academic Press
Release Date : 2016-08-02

Biomarkers In Alzheimer S Disease written by Tapan Khan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-02 with Science categories.


Biomarkers in Alzheimer’s Disease provides a comprehensive overview of all modalities of Alzheimer’s disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer’s disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer’s disease, and for differential diagnosis of Alzheimer’s disease with other non-Alzheimer’s dementia. Presents a comprehensive overview detailing all modalities of Alzheimer’s disease biomarkers Written for neuroscience researchers and clinicians studying or treating patients with Alzheimer’s Disease Integrates, in each chapter, the molecular/cellular abnormality due to Alzheimer’s disease and the technological advancement of biomarkers techniques



Neuroscience Trials Of The Future


Neuroscience Trials Of The Future
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-12-07

Neuroscience Trials Of The Future written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-07 with Medical categories.


On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.



Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System


Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-07-05

Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-05 with Medical categories.


Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.



Multimodal Biomarkers For Central Nervous System Disorders


Multimodal Biomarkers For Central Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher:
Release Date : 2024-05-29

Multimodal Biomarkers For Central Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-29 with categories.


A key step towards reducing the burden of central nervous system (CNS) disorders is the identification of disease-specific biomarkers that can help predict, monitor, and guide treatment development. Recent technological advances have led to an increased number of biomarkers for different CNS disorders, providing the opportunity to generate multimodal biomarkers. While multimodal biomarkers can serve as promising tools to better diagnose and make accurate disease assessments, there remain challenges in current data collection, standardization, and validation practices that impede in their development. Recognizing the need for increased CNS biomarker integration, the National Academies Forum on Neuroscience and Nervous System Disorders hosted a public workshop in March 2023 to explore steps toward this goal, including data collection for biomarker discovery, development, validation, and assessment of clinical utility. This Proceedings of a Workshop summarizes the discussions held during the workshop.



Advanced Biomarkers For Neurological Diseases


Advanced Biomarkers For Neurological Diseases
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Author : Noah Benge
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-19

Advanced Biomarkers For Neurological Diseases written by Noah Benge and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Medical categories.


The diseases of the central or peripheral nervous system are called neurological disorders. These disorders include epilepsy, Alzheimer's disease, and other dementias. Cerebrovascular diseases such as stroke, migraine, multiple sclerosis, Parkinson's disease, etc. are also considered as neurological diseases. A biomarker or biological marker is a cell, tissue, or body fluid cell that can be measured and evaluated to indicate a pharmacological response to a normal biological process, pathogenic process, or therapeutic intervention. Biomarkers characterize the progression of the disease from the earliest natural signs of the disease. Biomarkers assess the disease susceptibility and severity enabling prediction of outcomes, deciding interventions, and assessing the therapeutic responses. Based on clinical applications, biomarkers can be categorized as molecular biomarkers, cellular biomarkers, or imaging biomarkers. This book aims to shed light on some of the unexplored aspects of biomarkers. It presents researches and studies performed by experts across the globe on the topic in detail. It attempts to assist those with a goal of furthering their studies in the field of biomarkers and biomarker development.



Biomarkers Of Neurological Diseases


Biomarkers Of Neurological Diseases
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Author : Noah Benge
language : en
Publisher: States Academic Press
Release Date : 2023-09-26

Biomarkers Of Neurological Diseases written by Noah Benge and has been published by States Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Health & Fitness categories.


Neurological diseases are disorders of the nervous system that affect the functioning of the brain and the nerves found throughout the human body and the spinal cord. The most common neurological disorders are epilepsy, Alzheimer's disease, migraine, stroke, Parkinson's disease, multiple sclerosis and cerebral palsy. The term biomarker or biological marker refers to a biological molecule found in blood, tissues or other body fluids, which indicates a normal or abnormal process, a condition, or a disease. Biomarkers help to diagnose a disease or condition, or to detect the disease progression, and record the effect of new drugs and therapeutic strategies as they are generated. Neurological biomarkers are used to diagnose a variety of neurological disorders and to monitor the advancement of these diseases or effect of the treatment. This process aids in predicting outcomes, determining interventions, and evaluating the therapeutic responses. This book is compiled in such a manner, that it will provide an in-depth knowledge about neurological biomarkers. It is a vital tool for all researching or studying the biomarkers of neurological diseases.



Handbook Of Medical Sociology Sixth Edition


Handbook Of Medical Sociology Sixth Edition
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Author : Chloe E. Bird
language : en
Publisher: Vanderbilt University Press
Release Date : 2010-11-29

Handbook Of Medical Sociology Sixth Edition written by Chloe E. Bird and has been published by Vanderbilt University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-29 with Medical categories.


The latest version of an important academic resource published about once a decade since 1963



Drug Delivery Strategies In Neurological Disorders Challenges And Opportunities


Drug Delivery Strategies In Neurological Disorders Challenges And Opportunities
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Author : Awanish Mishra
language : en
Publisher: Springer Nature
Release Date :

Drug Delivery Strategies In Neurological Disorders Challenges And Opportunities written by Awanish Mishra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.