New Aspects Of Axonal Structure And Function
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New Aspects Of Axonal Structure And Function
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Author : Dirk Feldmeyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-18
New Aspects Of Axonal Structure And Function written by Dirk Feldmeyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-18 with Medical categories.
Axons are neuronal output elements and are responsible for the transfer and processing of signals from one neuron to another, even over very large distances. For a given neuronal cell type, axons are unique and display very heterogeneous patterns with respect to shape, length and target structure. Axons are the usually long process of a nerve fiber that generally conducts impulses away from the body of the nerve cell. This book is intended to summarize recent findings covering morphological, physiological, developmental, computational and pathophysiological aspects of axons. It attempts to cover new findings concerning axonal structure and functions together with their implications for signal transduction, processes implicated in the formation of axonal arbors and the transport of subcellular elements to their targets, and finally how a dysfunction in one or several of these steps could lead to axonal degeneration and ultimately to neurodegenerative diseases.
New Aspects In Analyzing The Synaptic Organization Of The Brain
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Author : Joachim H.R. Lübke
language : en
Publisher: Springer Nature
Release Date : 2024-08-27
New Aspects In Analyzing The Synaptic Organization Of The Brain written by Joachim H.R. Lübke and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-27 with Science categories.
This volume looks at the latest methodological developments used in the field to investigate the synaptic organization of the brain from different viewpoints including structural, structural/functional, molecular, and computational methods. The chapters in this book are organized into five parts and cover topics such as preparation of brain tissue and techniques; connectivity; synaptic vesicles; phenomenological modeling; and dendritic spines. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and thorough, New Aspects in Analyzing the Synaptic Organization of the Brain is a valuable resource that will help students, post-docs, and even expert researchers learn more about the discipline of cellular and synaptic neuroscience.
Axons And Brain Architecture
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Author : Kathleen Rockland
language : en
Publisher: Academic Press
Release Date : 2015-11-21
Axons And Brain Architecture written by Kathleen Rockland and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-21 with Science categories.
Several excellent monographs exist which deal with axons. These, however, focus either on the cellular and molecular biology of axons proper or on network organization of connections, the latter with only an incidental or abstract reference to axons per se. Still relatively neglected, however, is the middle ground of terminations and trajectories of single axons in the mammalian central nervous system. This middle level of connectivity, between networks on the one hand and local, in vitro investigations on the other, is to some extent represented by retrograde tracer studies and labeled neurons, but there have so far been many fewer of the complementary anterograde studies, with total visualization of the axonal arborization. The present volume brings together in one source an interrelated treatment of single axons from the perspective of microcircuitry and as substrates of larger scale organization (tractography). Especially for the former area - axons in microcircuitry - an abundance of published data exists, but these are typically in specialty journals that are not often accessed by the broader community. By highlighting and unifying the span from microcircuitry to tractography, the proposed volume serves as a convenient reference source and in addition inspires further interactions between what currently tend to be separate communities. The volume also redresses the imbalance between in vitro/local connectivity and long-distance connections. Focusing on mammalian systems, Part 1 of this book is devoted to anatomical investigations of connections at the single axon level, drawing on modern techniques and classical methods from the 1990s. A particular emphasis is on broad coverage of cortical and subcortical connections from different species, so that common patterns of divergence, convergence, and collateralization can be easily appreciated. Part 2 addresses mechanisms of axon guidance, as these seem particularly relevant to pathways and branching patterns. Part 3 covers axon dynamics and functional aspects; and Part 4 focuses on tractography, notably including comparisons between histological substrates and imaging. - A novel innovative reference on the axon as a connectional unit, encompassing microcircuitry, axon guidance, and function - Featuring chapters from leading researchers in the field - Full-colour text that includes both an overview of axon function and the multiple underlying molecular mechanisms - The only volume to bring together the configuration of individual axons at a circuit level and to relate the histological geometry of axons and axon bundles to in vivo tractography imaging studies
Neuroanatomy For The Xxist Century
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Author : Kathleen S. Rockland
language : en
Publisher: Frontiers Media SA
Release Date : 2016-08-15
Neuroanatomy For The Xxist Century written by Kathleen S. Rockland and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-15 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the newer techniques. A second goal is to showcase what has become the conspicuous interdisciplinary reach of the field: neuroanatomical standards and the close association of structure-function and underlying circuitry mechanisms are increasingly relevant to investigations in development, physiology, and disease. Another feature of this Research Topic is that it includes a breadth of cross-species contributions from investigators working with rodent, nonhuman primate, and human brains. This is important since most of our current knowledge of brain structure has been obtained from experimental animals. However, recent technical advances, coupled with researcher willingness to use the human tissue available, will undoubtedly lead to major advances in the near future regarding human brain mapping and connectomes. Thus, of particular interest will be the methods that can help to define general wiring principles in the brain, both structural and functional. Overall, the state of the field is: exciting.
Basic Neurochemistry
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Author : R. Wayne Albers
language : en
Publisher: Academic Press
Release Date : 2011-11-02
Basic Neurochemistry written by R. Wayne Albers and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Science categories.
Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. - Completely updated text with new authors and material, and many entirely new chapters - Over 400 fully revised figures in splendid color - 61 chapters covering the range of cellular, molecular and medical neuroscience - Translational science boxes emphasizing the connections between basic and clinical neuroscience - Companion website at http://elsevierdirect.com/companions/9780123749475
Neuroproteomics
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Author : Oscar Alzate
language : en
Publisher: CRC Press
Release Date : 2009-10-26
Neuroproteomics written by Oscar Alzate and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-26 with Medical categories.
In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg
Translational Research In Traumatic Brain Injury
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Author : Daniel Laskowitz
language : en
Publisher: CRC Press
Release Date : 2016-04-21
Translational Research In Traumatic Brain Injury written by Daniel Laskowitz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-21 with Medical categories.
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Nolte S The Human Brain E Book
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Author : Todd W. Vanderah
language : en
Publisher: Elsevier Health Sciences
Release Date : 2020-02-05
Nolte S The Human Brain E Book written by Todd W. Vanderah and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-05 with Medical categories.
Throughout seven popular editions, Nolte's The Human Brain has accomplished the challenging task of demystifying the complexities of the gross anatomy of the brain, spinal cord, and brainstem. A clear writing style, interesting examples, and high-quality visual cues bring this complicated subject to life and make it more understandable and enjoyable to learn. You'll get the depth of coverage you need with a well-rounded presentation of all key topics in functional neuroanatomy and neuroscience. - Features highly templated, concise chapters that reinforce and expand your knowledge. - Provides a real-life perspective through clinically relevant examples, up-to-date neuroimaging techniques, and superb illustrations that support and explain the text. - Features a glossary of key terms that elucidates every part of the text, complimented by 3-dimensional images of the brain and the most up-to-date terminology throughout. - Helps you gauge your mastery of the material and build confidence with over 100 multiple choice questions available online that provide effective chapter review and quick practice for your exams. - New! Clinical Focus Boxes, including neuropathology and neuropharmacology. - New! Integrated coverage of neurogenetics and neuroimmunology. - Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.
Computational Modelling Of The Brain
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Author : Michele Giugliano
language : en
Publisher: Springer Nature
Release Date : 2022-04-26
Computational Modelling Of The Brain written by Michele Giugliano and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Medical categories.
This volume offers an up-to-date overview of essential concepts and modern approaches to computational modelling, including the use of experimental techniques related to or directly inspired by them. The book introduces, at increasing levels of complexity and with the non-specialist in mind, state-of-the-art topics ranging from single-cell and molecular descriptions to circuits and networks. Four major themes are covered, including subcellular modelling of ion channels and signalling pathways at the molecular level, single-cell modelling at different levels of spatial complexity, network modelling from local microcircuits to large-scale simulations of entire brain areas and practical examples. Each chapter presents a systematic overview of a specific topic and provides the reader with the fundamental tools needed to understand the computational modelling of neural dynamics. This book is aimed at experimenters and graduate students with little or no prior knowledge of modelling who are interested in learning about computational models from the single molecule to the inter-areal communication of brain structures. The book will appeal to computational neuroscientists, engineers, physicists and mathematicians interested in contributing to the field of neuroscience. Chapters 6, 10 and 11 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Structure And Function In Excitable Cells
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Author : Donald Cheng
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Structure And Function In Excitable Cells written by Donald Cheng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
This book is a collection of up-to-date research reviews dealing with various aspects of the structure and function of excitable cells. Its overall objective is to further the search for a better understanding of the mechanism of excitation on a structural and physicochemical basis. The chapters are written by active investigators from a variety of disciplines, repre senting many different points of view. Their complementary fields of expertise give this book the rare feature of extraordinary breadth. Excitability is a fundamental property of many biological systems. The mechanisms by which nerve impulses are initiated and propagated, and by which rhythmical activities are produced in nerve, muscle, and cardiac cells, can be fully elucidated only when the process of excitation is derived from fundamental principles applied to known structural forms, at both the macroscopic and the molecular level. The problems of excitation are complex, requiring knowledge of many aspects of cells, including their morphology, elec trobiology, chemical physics, and biochemistry.