New High Throughput Technologies For Dna Sequences And Genomics Vol 2
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New High Throughput Technologies For Dna Sequences And Genomics Vol 2
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Author : Keith R. Mitchelson
language : en
Publisher:
Release Date : 2006
New High Throughput Technologies For Dna Sequences And Genomics Vol 2 written by Keith R. Mitchelson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
New High Throughput Technologies For Dna Sequencing And Genomics
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Author : Keith R. Mitchelson
language : en
Publisher: Elsevier
Release Date : 2011-09-22
New High Throughput Technologies For Dna Sequencing And Genomics written by Keith R. Mitchelson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Science categories.
Since the independent invention of DNA sequencing by Sanger and by Gilbert 30 years ago, it has grown from a small scale technique capable of reading several kilobase-pair of sequence per day into today's multibillion dollar industry. This growth has spurred the development of new sequencing technologies that do not involve either electrophoresis or Sanger sequencing chemistries. Sequencing by Synthesis (SBS) involves multiple parallel micro-sequencing addition events occurring on a surface, where data from each round is detected by imaging. New High Throughput Technologies for DNA Sequencing and Genomics is the second volume in the Perspectives in Bioanalysis series, which looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century. Reviews of complementary developments in Sanger and SBS sequencing chemistries, capillary electrophoresis and microdevice integration, MS sequencing and applications set the framework for the book. * 'Hot Topic' with DNA sequencing continuing as a major research activity in many areas of life science and medicine. * Bringing together new developments in DNA sequencing technology * Reviewing issues relevant to the new applications used
Next Generation Sequencing
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Author : Jerzy Kulski
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-01-14
Next Generation Sequencing written by Jerzy Kulski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-14 with Medical categories.
Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
Field Guidelines For Genetic Experimental Designs In High Throughput Sequencing
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Author : Ana M. Aransay
language : en
Publisher: Springer
Release Date : 2016-06-02
Field Guidelines For Genetic Experimental Designs In High Throughput Sequencing written by Ana M. Aransay and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-02 with Medical categories.
High throughput sequencing (HTS) technologies have conquered the genomics and epigenomics worlds. The applications of HTS methods are wide, and can be used to sequence everything from whole or partial genomes, transcriptomes, non-coding RNAs, ribosome profiling, to single-cell sequencing. Having such diversity of alternatives, there is a demand for information by research scientists without experience in HTS that need to choose the most suitable methodology or combination of platforms and to define their experimental designs to achieve their specific objectives. Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing aims to collect in a single volume all aspects that should be taken into account when HTS technologies are being incorporated into a research project and the reasons behind them. Moreover, examples of several successful strategies will be analyzed to make the point of the crucial features. This book will be of use to all scientist that are unfamiliar with HTS and want to incorporate such technologies to their research.
Dna Sequencing Ii
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Author : Jan Kieleczawa
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2006
Dna Sequencing Ii written by Jan Kieleczawa and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with DNA categories.
Dr. Kieleczawa's second volume, DNA Sequencing II: Optimizing the Preparation and Clean-Up, is devoted to the various methods used for extraction, clean-up, quantification, and analysis of DNA. This volume is divided into four comprehensive sections - DNA Purification, Cleanup of DNA Fragments, Storage of DNA, and Quantifying DNA and RNA - and offers the reader an in-depth presentation of DNA technologies. The text also touches upon the many tools and software programs that are found in a typical modern biology laboratory. This fascinating text is a wonderful addition to your molecular biology library.
Next Generation Sequencing In Cancer Research
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Author : Wei Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-04
Next Generation Sequencing In Cancer Research written by Wei Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-04 with Medical categories.
This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.
Next Generation Sequencing Technologies And Challenges In Sequence Assembly
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Author : Sara El-Metwally
language : en
Publisher: Springer Science & Business
Release Date : 2014-04-19
Next Generation Sequencing Technologies And Challenges In Sequence Assembly written by Sara El-Metwally and has been published by Springer Science & Business this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-19 with Science categories.
The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
Genomics Ii
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Author : Iconcept Press
language : en
Publisher: CreateSpace
Release Date : 2013-10
Genomics Ii written by Iconcept Press and has been published by CreateSpace this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10 with Medical categories.
Genomics is the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping efforts. It is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes. Genomics II - Bacteria, Viruses and Metabolic Pathways is the second volume of our Genomics series. There are totally three volumes in this series. Chapter 1 describes an analysis and statistical scoring approach for cellular assay data based on single-cell information. In Chapter 2, the concept of metabolic pathways analysis is introduced. The mathematic principle of extreme pathway and elementary flux mode are compared. Chapter 3 is dedicated to the Pathway- and Network-based analysis of the high-throughput genomic data. The author introduced Reactome FI Cytoscape plugin that can construct a network based on the list of genes of interest, cluster the constructed network, and annotate network modules based on pathways and Gene Ontology terms. Chapter 4 provides a review of microarray and RNA-seq techniques for high-throughput gene expression measurements, discusses the strategies and issues of high-level analysis on gene expression data, and introduces a new algorithm for analyzing microarray data. Chapter 5 summarizes our current understanding of the intracellular defenses by APOBEC family against invading nucleic acids including endogenous retroelements that make up more than 40% of the mammalian genome. Chapter 6 discusses immunoinformatics software that can be employed to study the evolution of antigenic epitopes. Chapter 7 discusses the integration of retroviral genome into host DNA, which is a critical step in the life cycle of a retrovirus. The authors developed an assay using some target DNA sequences from common MLV integration sites in the genome of murine lymphomas and an HIV-1 integration site in the genome of T cell integrated into the target DNA in vitro. Chapter 8 discusses how microarray can be as a promising new technology for broad-spectrum pathogen detection, making it possible to test for the presence of thousands of viruses simultaneously. Chapter 9 discusses the origin of the unilateral aminoacylation specificity based on mt SerRS as a typical example. Mitochondrial (mt) aminoacyl-tRNA synthetases (aaRSs) are able to charge both mt and bacterial cognate tRNAs, whereas most bacterial synthetases including serine (Ser) are only able to charge bacterial cognate tRNAs, whose phenomenon is termed unilateral aminoacylation specificity between mitochondria and bacteria. In Chapter 10, the authors chosen Cytoplasmic polyhedrosis virus (CPV) and hepatitis B virus (HBV) to demonstrate how we can using structural biology techniques to explore the viral genome, such as genome package and distribution, and mRNA transcribing/capping/releasing of viruses. Chapter 11 provides an overview of the steps required to correctly perform the genotypic resistance test; a detailed description of computational programs used for the interpretation of this assay is reported. Chapter 12 discusses Influenza C virus, which is a member of the Orthomyxoviridae, a family comprising viruses with segmented single-stranded RNA genomes of negative polarity. Chapter 13 provides comprehensive essential genes of Streptococcus sanguinis and compares them among streptococcal species. A model has been created to predict essential genes in bacteria. Chapter 14 discusses Lactobacillus casei Zhang, which was a new probiotic bacterium isolated from traditional home-made koumiss in Inner Mongolia of China. Chapter 15 discusses how the association of comparative genome analysis and protein structure prediction methods could help in high-throughput genome analysis aiming the structure-based rational drug design.
Next Generation Genome Sequencing
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Author : Michal Janitz
language : en
Publisher: Wiley-Blackwell
Release Date : 2008-10-20
Next Generation Genome Sequencing written by Michal Janitz and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-20 with Science categories.
Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.
Next Generation Genome Sequencing
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Author : Michal Janitz
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-24
Next Generation Genome Sequencing written by Michal Janitz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-24 with Science categories.
Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.