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New Insights Into Microbial Ecology Through Subtle Nucleotide Variation


New Insights Into Microbial Ecology Through Subtle Nucleotide Variation
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New Insights Into Microbial Ecology Through Subtle Nucleotide Variation


New Insights Into Microbial Ecology Through Subtle Nucleotide Variation
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Author : A. Murat Eren
language : en
Publisher: Frontiers Media SA
Release Date : 2016-10-26

New Insights Into Microbial Ecology Through Subtle Nucleotide Variation written by A. Murat Eren and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-26 with Microbiology categories.


The 16S ribosomal RNA gene commonly serves as a molecular marker for investigating microbial community composition and structure. Vast amounts of 16S rRNA amplicon data generated from environmental samples thanks to the recent advances in sequencing technologies allowed microbial ecologists to explore microbial community dynamics over temporal and spatial scales deeper than ever before. However, widely used methods for the analysis of bacterial communities generally ignore subtle nucleotide variations among high-throughput sequencing reads and often fail to resolve ecologically meaningful differences between closely related organisms in complex microbial datasets. Lack of proper partitioning of the sequencing data into relevant units often masks important ecological patterns. Our research topic contains articles that use oligotyping to demonstrate the importantance of high-resolution analyses of marker gene data, and providides further evidence why microbial ecologists should open the "black box" of OTUs identified through arbitrary sequence similarity thresholds.



An Integrated Analysis Of Microbiomes And Metabolomics


An Integrated Analysis Of Microbiomes And Metabolomics
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Author : Yinglin Xia
language : en
Publisher: American Chemical Society
Release Date : 2022-03-25

An Integrated Analysis Of Microbiomes And Metabolomics written by Yinglin Xia and has been published by American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-25 with Science categories.


Because the microbial community is dynamic, an individual’s microbiota at a given time is varied, and many factors, including age, host genetics, diet, and the local environment, significantly change the microbiota. Thus, microbiome researchers have naturally expanded their research to look for insights into the interaction of the microbiome with other “omics”. Metabolites (small molecules) are the intermediate or end products of metabolism. Metabolites have various functions. The microbial-derived metabolites play an important role in the function of the microbiome. Thus, the advancement in microbiome studies is becoming particularly critical for the integration of microbial DNA sequencing data with other omics data, especially microbiome-metabolomics integration.



Bioinformatic And Statistical Analysis Of Microbiome Data


Bioinformatic And Statistical Analysis Of Microbiome Data
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Author : Yinglin Xia
language : en
Publisher: Springer Nature
Release Date : 2023-06-16

Bioinformatic And Statistical Analysis Of Microbiome Data written by Yinglin Xia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-16 with Science categories.


This unique book addresses the bioinformatic and statistical modelling and also the analysis of microbiome data using cutting-edge QIIME 2 and R software. It covers core analysis topics in both bioinformatics and statistics, which provides a complete workflow for microbiome data analysis: from raw sequencing reads to community analysis and statistical hypothesis testing. It includes real-world data from the authors’ research and from the public domain, and discusses the implementation of QIIME 2 and R for data analysis step-by-step. The data as well as QIIME 2 and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter so that these new methods can be readily applied in their own research. Bioinformatic and Statistical Analysis of Microbiome Data is an ideal book for advanced graduate students and researchers in the clinical, biomedical, agricultural, and environmental fields, as well as those studying bioinformatics, statistics, and big data analysis.



Statistical Data Analysis Of Microbiomes And Metabolomics


Statistical Data Analysis Of Microbiomes And Metabolomics
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Author : Yinglin Xia
language : en
Publisher: American Chemical Society
Release Date : 2022-02-03

Statistical Data Analysis Of Microbiomes And Metabolomics written by Yinglin Xia and has been published by American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-03 with Science categories.


Compared with other research fields, both microbiome and metabolomics data are complicated and have some unique characteristics, respectively. Thus, choosing an appropriate statistical test or method is a very important step in the analysis of microbiome and metabolomics data. However, this is still a difficult task for those biomedical researchers without a statistical background and for those biostatisticians who do not have research experiences in these fields. Graduate students studying microbiome and metabolomics; statisticians, working on microbiome and metabolomics projects, either for their own research, or for their collaborative research for experimental design, grant application, and data analysis; and researchers who investigate biomedical and biochemical projects with the microbiome, metabolome, and multi-omics data analysis will benefit from reading this work.



New Insights Into Microbial Ecology Through Subtle Nucleotide Variation


New Insights Into Microbial Ecology Through Subtle Nucleotide Variation
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Author :
language : en
Publisher:
Release Date : 2016

New Insights Into Microbial Ecology Through Subtle Nucleotide Variation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.


The 16S ribosomal RNA gene commonly serves as a molecular marker for investigating microbial community composition and structure. Vast amounts of 16S rRNA amplicon data generated from environmental samples thanks to the recent advances in sequencing technologies allowed microbial ecologists to explore microbial community dynamics over temporal and spatial scales deeper than ever before. However, widely used methods for the analysis of bacterial communities generally ignore subtle nucleotide variations among high-throughput sequencing reads and often fail to resolve ecologically meaningful differences between closely related organisms in complex microbial datasets. Lack of proper partitioning of the sequencing data into relevant units often masks important ecological patterns. Our research topic contains articles that use oligotyping to demonstrate the importantance of high-resolution analyses of marker gene data, and providides further evidence why microbial ecologists should open the "black box" of OTUs identified through arbitrary sequence similarity thresholds.



Game Changer Next Generation Sequencing And Its Impact On Food Microbiology


Game Changer Next Generation Sequencing And Its Impact On Food Microbiology
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Author : Jennifer Ronholm
language : en
Publisher: Frontiers Media SA
Release Date : 2018-04-26

Game Changer Next Generation Sequencing And Its Impact On Food Microbiology written by Jennifer Ronholm and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-26 with categories.


Advances in next-generation sequencing technologies (NGS) are revolutionizing the field of food microbiology. Microbial whole genome sequencing (WGS) can provide identification, characterization, and subtyping of pathogens for epidemiological investigations at a level of precision previously not possible. This allows for connections and source attribution to be inferred between related isolates that may be overlooked by traditional techniques. The archiving and global sharing of genome sequences allow for retrospective analysis of virulence genes, antimicrobial resistance markers, mobile genetic elements and other novel genes. The advent of high-throughput 16S rRNA amplicon sequencing, in combination with the advantages offered by massively parallel second-generation sequencing for metagenomics, enable intensive studies on the microbiomes of food products and the impact of foods on the human microbiome. These studies may one day lead to the development of reliable culture-independent methods for food monitoring and surveillance. Similarly, RNA-seq has provided insights into the transcriptomes and hence the behaviour of bacterial pathogens in food, food processing environments, and in interaction with the host at a resolution previously not achieved through the use of microarrays and/or RT-PCR. The vast un-tapped potential applications of NGS along with its rapidly declining costs, give this technology the ability to contribute significantly to consumer protection, global trade facilitation, and increased food safety and security. Despite the rapid advances, challenges remain. How will NGS data be incorporated into our existing global food safety infrastructure? How will massive NGS data be stored and shared globally? What bioinformatics solutions will be used to analyse and optimise these large data sets? This Research Topic discusses recent advances in the field of food microbiology made possible through the use of NGS.



Microbiomes Of The Built Environment


Microbiomes Of The Built Environment
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-10-06

Microbiomes Of The Built Environment written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-06 with Science categories.


People's desire to understand the environments in which they live is a natural one. People spend most of their time in spaces and structures designed, built, and managed by humans, and it is estimated that people in developed countries now spend 90 percent of their lives indoors. As people move from homes to workplaces, traveling in cars and on transit systems, microorganisms are continually with and around them. The human-associated microbes that are shed, along with the human behaviors that affect their transport and removal, make significant contributions to the diversity of the indoor microbiome. The characteristics of "healthy" indoor environments cannot yet be defined, nor do microbial, clinical, and building researchers yet understand how to modify features of indoor environmentsâ€"such as building ventilation systems and the chemistry of building materialsâ€"in ways that would have predictable impacts on microbial communities to promote health and prevent disease. The factors that affect the environments within buildings, the ways in which building characteristics influence the composition and function of indoor microbial communities, and the ways in which these microbial communities relate to human health and well-being are extraordinarily complex and can be explored only as a dynamic, interconnected ecosystem by engaging the fields of microbial biology and ecology, chemistry, building science, and human physiology. This report reviews what is known about the intersection of these disciplines, and how new tools may facilitate advances in understanding the ecosystem of built environments, indoor microbiomes, and effects on human health and well-being. It offers a research agenda to generate the information needed so that stakeholders with an interest in understanding the impacts of built environments will be able to make more informed decisions.



Textbook Of Periodontics


Textbook Of Periodontics
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Author : Shalu Bathla
language : en
Publisher: Jaypee Brothers Medical Publishers
Release Date : 2021-02-10

Textbook Of Periodontics written by Shalu Bathla and has been published by Jaypee Brothers Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-10 with Medical categories.


Section 1: Normal Periodontium Section 2: Classification and Epidemiology Section 3: Etiology Section 4: Pathology of Gingival and Periodontal Diseases Section 5: Diagnosis Section 6: Treatment: Nonsurgical Therapy Section 7: Treatment: Surgical Therapy Section 8: Implantology Section 9: Interdisciplinary Approach Section 10: Recent Advances Section 11: Maintenance Phase Section 12: Miscellaneous



Biological Diversity


Biological Diversity
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Author : L. N. Petrov
language : en
Publisher: Nova Publishers
Release Date : 2003

Biological Diversity written by L. N. Petrov and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Reference categories.


One of the cornerstones of life's wonders is the vast array of species filling the planet. From plants to animals to humans, there is no shortage of beings to provide 'spice of life' variety is said to be. Periodically, scientists announce the discovery of a 'new' form of life, so it seems as if Earth is capable of producing new species just to keep us on our toes. At times, the immense breadth of living things can even feel overwhelming, as one pauses to ponder how numerically insignificant humans are when compared to the insect population. Given the biological diversity of the planet, it is incumbent upon humans to safeguard the natural beauty of the environment. To that end, conservation takes on special importance, necessitating the balancing of industrial expansion with preserving the flora and fauna surrounding us. This book is an important tool in understanding and researching the many different life forms spanning the globe. Collected here is a substantial and carefully selected listing of relevant literature on biological diversity and its conservation. Following this bibliography are author, title, and subject indexes to allow for further access to this information. The sheer bulk of the works about biological diversity can be so intimidating that a book such as this one becomes useful in sorting through the resources about the importance of life's variety.



Pharmaceutical Biotechnology


Pharmaceutical Biotechnology
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Author : Daan J. A. Crommelin
language : en
Publisher: Springer
Release Date : 2019-04-13

Pharmaceutical Biotechnology written by Daan J. A. Crommelin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-13 with Science categories.


This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, and also includes additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech and enzyme replacement therapy.