Statistical Data Analysis Of Microbiomes And Metabolomics

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Statistical Data Analysis Of Microbiomes And Metabolomics

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Author : Yinglin Xia
language : en
Publisher: American Chemical Society
Release Date : 2022-02-03

Statistical Data Analysis Of Microbiomes And Metabolomics written by Yinglin Xia and has been published by American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-03 with Science categories.

Compared with other research fields, both microbiome and metabolomics data are complicated and have some unique characteristics, respectively. Thus, choosing an appropriate statistical test or method is a very important step in the analysis of microbiome and metabolomics data. However, this is still a difficult task for those biomedical researchers without a statistical background and for those biostatisticians who do not have research experiences in these fields. Graduate students studying microbiome and metabolomics; statisticians, working on microbiome and metabolomics projects, either for their own research, or for their collaborative research for experimental design, grant application, and data analysis; and researchers who investigate biomedical and biochemical projects with the microbiome, metabolome, and multi-omics data analysis will benefit from reading this work.

An Integrated Analysis Of Microbiomes And Metabolomics

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Author : Yinglin Xia
language : en
Publisher: American Chemical Society
Release Date : 2022-03-25

An Integrated Analysis Of Microbiomes And Metabolomics written by Yinglin Xia and has been published by American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-25 with Science categories.

Because the microbial community is dynamic, an individual’s microbiota at a given time is varied, and many factors, including age, host genetics, diet, and the local environment, significantly change the microbiota. Thus, microbiome researchers have naturally expanded their research to look for insights into the interaction of the microbiome with other “omics”. Metabolites (small molecules) are the intermediate or end products of metabolism. Metabolites have various functions. The microbial-derived metabolites play an important role in the function of the microbiome. Thus, the advancement in microbiome studies is becoming particularly critical for the integration of microbial DNA sequencing data with other omics data, especially microbiome-metabolomics integration.

Bioinformatic And Statistical Analysis Of Microbiome Data

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Author : Yinglin Xia
language : en
Publisher: Springer Nature
Release Date : 2023-06-16

Bioinformatic And Statistical Analysis Of Microbiome Data written by Yinglin Xia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-16 with Science categories.

This unique book addresses the bioinformatic and statistical modelling and also the analysis of microbiome data using cutting-edge QIIME 2 and R software. It covers core analysis topics in both bioinformatics and statistics, which provides a complete workflow for microbiome data analysis: from raw sequencing reads to community analysis and statistical hypothesis testing. It includes real-world data from the authors’ research and from the public domain, and discusses the implementation of QIIME 2 and R for data analysis step-by-step. The data as well as QIIME 2 and R computer programs are publicly available, allowing readers to replicate the model development and data analysis presented in each chapter so that these new methods can be readily applied in their own research. Bioinformatic and Statistical Analysis of Microbiome Data is an ideal book for advanced graduate students and researchers in the clinical, biomedical, agricultural, and environmental fields, as well as those studying bioinformatics, statistics, and big data analysis.

Applied Microbiome Statistics

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Author : Yinglin Xia
language : en
Publisher: CRC Press
Release Date : 2024-07-22

Applied Microbiome Statistics written by Yinglin Xia and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-22 with Mathematics categories.

This unique book officially defines microbiome statistics as a specific new field of statistics and addresses the statistical analysis of correlation, association, interaction, and composition in microbiome research. It also defines the study of the microbiome as a hypothesis-driven experimental science and describes two microbiome research themes and six unique characteristics of microbiome data, as well as investigating challenges for statistical analysis of microbiome data using the standard statistical methods. This book is useful for researchers of biostatistics, ecology, and data analysts. Presents a thorough overview of statistical methods in microbiome statistics of parametric and nonparametric correlation, association, interaction, and composition adopted from classical statistics and ecology and specifically designed for microbiome research. Performs step-by-step statistical analysis of correlation, association, interaction, and composition in microbiome data. Discusses the issues of statistical analysis of microbiome data: high dimensionality, compositionality, sparsity, overdispersion, zero-inflation, and heterogeneity. Investigates statistical methods on multiple comparisons and multiple hypothesis testing and applications to microbiome data. Introduces a series of exploratory tools to visualize composition and correlation of microbial taxa by barplot, heatmap, and correlation plot. Employs the Kruskal–Wallis rank-sum test to perform model selection for further multi-omics data integration. Offers R code and the datasets from the authors’ real microbiome research and publicly available data for the analysis used. Remarks on the advantages and disadvantages of each of the methods used.

Microbiome And The Eye

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Author : Anat Galor
language : en
Publisher: Elsevier
Release Date : 2023-06-20

Microbiome And The Eye written by Anat Galor and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-20 with Science categories.

Microbiome and the Eye: What's the connection? highlights how alterations in the gut and eye microbiomes can lead to systemic immune alterations with subsequent effects on the eye. The book is divided into two sections, one highlighting how alterations in the gut microbiome impact various components of health outside the gut, with a focus on the immune system and inflammatory mediators, and the second focusing on studies on a variety of ocular diseases, including ocular surface diseases/dry eye, keratitis, uveitis, glaucoma, and retinopathy to gut dysbiosis. With its translational approach, the book is suitable for both researchers and clinicians. The book will help readers understand the mechanisms in which gut and eye microbiome composition may influence health in multiple compartments, with a focus on eye diseases. - Helps researchers understand the clinical eye diseases that have been linked to gut microbiome abnormalities - Helps clinicians understand the mechanisms in which gut microbiome composition may influence health in multiple compartments - Provides a foundation for future studies that consider gut microbiome manipulations as a treatment for specific eye diseases

Handbook Of Statistical Genomics

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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-09

Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-09 with Science categories.

A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Plant Adaptation To Abiotic Stress From Signaling Pathways And Microbiomes To Molecular Mechanisms

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Author : Radhouane Chaffai
language : en
Publisher: Springer Nature
Release Date : 2024-05-23

Plant Adaptation To Abiotic Stress From Signaling Pathways And Microbiomes To Molecular Mechanisms written by Radhouane Chaffai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-23 with Science categories.

The book “Plant Adaptation to Abiotic Stress: From Signaling Pathways and Microbiomes to Molecular Mechanisms” comprehensively examines abiotic stressors—cold, heat, light, salinity, and water scarcity—across its 18 chapters. Focusing particularly on Arabidopsis thaliana, it investigates abiotic stresses, adaptation strategies, and molecular pathways. Furthermore, it addresses broader issues, including climate challenges, food security, water scarcity, and agricultural concerns such as soil acidity and aluminum stress. It proposes adaptive measures for cultivating stress-resistant crops and sheds light on genetic modification methods such as CRISPR-Cas9, integrating nanotechnology in plant breeding. Emphasizing transcription factors, post-translational protein modifications, and diverse noncoding RNAs (long noncoding RNAs, circular RNAs, microRNAs, and small interfering RNAs), the book highlights their role in regulating gene expression during stress responses. It specifically underscores secondary messengers, plant hormones, and MAPK cascades within intracellular signaling pathways. Additionally, it discusses the roles of endophytic bacteria and microbial interactions in bolstering stress resilience. The book explores state-of-the-art research methodologies in plant breeding, omics approaches, and nanotechnology integration for developing stress-resistant crop varieties, advocating for agricultural sustainability. Tailored for plant physiology scientists, academics, and postgraduate students, it amalgamates diverse research findings, serving as a pivotal resource to comprehend intricate plant responses to environmental challenges.

Statistical And Computational Methods For Microbiome Multi Omics Data

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Author : Himel Mallick
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-19

Statistical And Computational Methods For Microbiome Multi Omics Data written by Himel Mallick and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-19 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Metabolomics

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Author : Vijay Soni
language : en
Publisher: Springer Nature
Release Date : 2023-10-24

Metabolomics written by Vijay Soni and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-24 with Science categories.

This book Introduces the extensive applications of metabolomics from all possible areas of research and development so that not only an undergraduate can understand the advancement of metabolomics, but an entrepreneur can harness the knowledge to address possible problems to make a perfect tool to address their research question. Topics covered include the role of metabolomics in the development of agriculture, plant pathology, and their applications; the generalized application of the metabolomics and use of related technologies in various sectors of industries; and the future of metabolomics and upcoming related technologies that can fill the gap between different -omics and their applications for the betterment of humankind. This is an ideal book for university professors, researchers, and advanced-level scientists who are exploring different avenues in metabolomics. Availability of this concise information in one place will aid scientists by expanding their arsenal of techniques and can be helpful to bring more collaborations and to identify the expert at the global level.

The Plant Holobiont Volume Ii Impacts Of The Rhizosphere On Plant Health

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Author : Nadia Lombardi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-07

The Plant Holobiont Volume Ii Impacts Of The Rhizosphere On Plant Health written by Nadia Lombardi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-07 with Science categories.