New Insights Into The Fabrication Of Drug Loaded Polymeric Micelles
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New Insights Into The Fabrication Of Drug Loaded Polymeric Micelles
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Author : Morteza Rasoulianboroujeni
language : en
Publisher:
Release Date : 2023
New Insights Into The Fabrication Of Drug Loaded Polymeric Micelles written by Morteza Rasoulianboroujeni and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
This study aimed to develop a safe and scalable method for fabricating drug-loaded polymeric micelles while addressing the challenges of long-term storage. Current fabrication methods present serious challenges in the development procedure, including the utilization of toxic solvents, the requirement for specialized equipment, and difficulties in solid form production. We hypothesized that by utilizing low molecular weight PEGs, known for their ability to dissolve hydrophobic drugs at elevated temperatures, as an alternative solvent, these challenges could be overcome in the production of drug-loaded micelles.We first focused on investigating micelle formation in a copolymer/PEG/water mixture using a model based on mean-field lattice theory. The model considered the free energy and translational entropy of the micelles, revealing the existence of entropy-driven liquid-liquid phase separation (LLPS) preceding micelle formation. This event can be controlled by varying the degree of polymerization. Experimental validation confirmed the accuracy of the model using PEG4kDa-b-PLA2.2kDa as the copolymer and PEG as the solvent. Building on this system, we introduced the "PEG-assist" method for fabricating drug-loaded polymeric micelles by hydrating a mixture of PEG, copolymer, and drug. The properties of the resulting micelles were influenced by the molecular weight of PEG and temperature, both areknown to impact LLPS and solvation power of PEG. The method's adaptability to other drugs and copolymers, scalability, freeze-drying feasibility, and stability were also proved. Furthermore, we proposed a formulation strategy for producing drug-loaded polymeric micelles directly from solid drug-loaded copolymer crystals. The crystals formed through crystallization from a supersaturated solution of the copolymer and drug in low molecular weight PEG. Parameters like PEG molecular weight and crystallization conditions were found to impact the formation of drug-loaded micelles through hydration and the properties of the resulting micelles. In summary, this study presents a comprehensive approach for fabricating drug-loaded polymeric micelles from a physical chemistry perspective, providing alternatives to current fabrication methods.
Polymeric Micelles For Drug Delivery
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Author : Prashant Kesharwani
language : en
Publisher: Woodhead Publishing
Release Date : 2022-08-18
Polymeric Micelles For Drug Delivery written by Prashant Kesharwani and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-18 with Technology & Engineering categories.
Polymeric Micelles for Drug Delivery provides a comprehensive overview on the synthesis, characterization and application of polymeric micelles in drug delivery applications. The use of nanomedicines and carriers, such as polymeric micelles, has made it possible to deliver drugs, genes and therapeutic agents to localized disease sites to maximize clinical benefit while limiting unwanted side effects. This book thoroughly reviews the development and application of polymeric micelles for drug delivery, covering various polymer types and the synthesis, characterization and pharmacokinetics of different micelles. Subsequent chapters go on to look at the range of drug delivery applications of polymeric micelles – such as mucosal and transdermal – and the assorted stimuli-responsive micelles available. The book concludes with an important analysis of the environmental and regulatory aspects associated with micelle development and clinical translation. Explores how polymeric micelles can be utilized in a range of different drug delivery approaches, from traditional oral delivery to ocular and dermal delivery Describes the various polymer types used in the synthesis and characterization of polymeric micelles Covers recent advances in polymeric micelles, such as drug co-delivery, triblock polymeric micelles, delivery of genetic materials, and more
Polymeric Micelles Principles Perspectives And Practices
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Author : Sachin Kumar Singh
language : en
Publisher: Springer Nature
Release Date : 2023-04-08
Polymeric Micelles Principles Perspectives And Practices written by Sachin Kumar Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-08 with Medical categories.
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
New Mechanisms For Anti Cancer Drugs
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Author : Ayaz Shahid
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-15
New Mechanisms For Anti Cancer Drugs written by Ayaz Shahid and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-15 with Science categories.
Cancer is the second leading cause of death. Every year, many anticancer drug candidates are discovered and synthesized, but the major challenge lies in identifying, characterizing and evaluating their efficacy. The aim of this Research Topic, "New Mechanisms for Anti-Cancer Drugs" is to collect a group of publications focused on novel chemical compounds exhibiting new modes of actions and/or new target proteins to fulfill their cytotoxic activity on cancer cells. In this context, we will also be pleased to consider studies on drug repurposing, including approved, discontinued, and shelved drugs, when anti-cancer activity results from an unexpected mode of action.
Nano And Microscale Drug Delivery Systems
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Author : Alexandru Mihai Grumezescu
language : en
Publisher: William Andrew
Release Date : 2017-03-27
Nano And Microscale Drug Delivery Systems written by Alexandru Mihai Grumezescu and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems. Shows how micro- and nanomaterials can be engineered to create more effective drug delivery systems Summarizes current nanotechnology research in the field of drug delivery systems Explores the pros and cons of using particular nanomaterials as therapeutic agents Serves as a valuable reference for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems
Biomedical Nanomaterials
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Author : Yuliang Zhao
language : en
Publisher: John Wiley & Sons
Release Date : 2016-12-12
Biomedical Nanomaterials written by Yuliang Zhao and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Science categories.
The book discusses in a detailed manner various nanomaterials used for biomedical applications, including clinical applications, diagnosis and tissue engineering. After the presentation of an overview of biomedical nanomaterials, including their classification and applications, the first part of the book is devoted to biomedical nanomaterials for therapy applications. For example, polymer micelles, dendrimers, polymer-drug conjugates as well as antibody-drug conjugates are discussed with respect to their cancer drug delivery properties. The next parts discuss biomedical nanomaterials that are used for imaging, diagnosis and sensors, as well as for tissue engineering. In the final section, the safety of biomedical nanomaterials is elaborated.
Nanoarchitectonics In Biomedicine
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Author : Alexandru Mihai Grumezescu
language : en
Publisher: William Andrew
Release Date : 2019-03-20
Nanoarchitectonics In Biomedicine written by Alexandru Mihai Grumezescu and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-20 with Medical categories.
Nanoarchitectonics in Biomedicine describes this new area of nanoscience that has emerged as a major branch of nanoscience. The book brings together recent applications and discusses the advantages and disadvantages of each process, offering international perspectives on the technologies based on these findings. It offers new insights for nanoarchitectonics, starting with the currently used methods of synthesis and characterization of such materials, along with their biomedical applications. Authored by a wide range of international scientists, this volume shows how nanoarchitectonics is being used to create more efficient medical treatment solutions. Users will find this to be an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science. Explores how design aspects, smart materials and personalized materials are used in biomedicine today Offers global perspectives on how nanoarchitectonics is used in different regions Presents an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science
Essentials Of 3d Biofabrication And Translation
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Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2015-07-17
Essentials Of 3d Biofabrication And Translation written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-17 with Science categories.
Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms
Design And Development Of New Nanocarriers
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Author : Alexandru Mihai Grumezescu
language : en
Publisher: William Andrew
Release Date : 2017-12-12
Design And Development Of New Nanocarriers written by Alexandru Mihai Grumezescu and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-12 with Science categories.
Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry
Applications Of Targeted Nano Drugs And Delivery Systems
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Author : Shyam Mohapatra
language : en
Publisher: Elsevier
Release Date : 2018-10-05
Applications Of Targeted Nano Drugs And Delivery Systems written by Shyam Mohapatra and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-05 with Science categories.
Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields. Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types