Polymeric Micelles Principles Perspectives And Practices
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Polymeric Micelles Principles Perspectives And Practices
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Author : Sachin Kumar Singh
language : en
Publisher: Springer Nature
Release Date : 2023-04-08
Polymeric Micelles Principles Perspectives And Practices written by Sachin Kumar Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-08 with Medical categories.
This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
Block Co Polymeric Nanocarriers Design Concept And Therapeutic Applications
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Author : Neeraj Mishra
language : en
Publisher: Springer Nature
Release Date : 2023-11-29
Block Co Polymeric Nanocarriers Design Concept And Therapeutic Applications written by Neeraj Mishra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-29 with Medical categories.
This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.
New Insights Into The Fabrication Of Drug Loaded Polymeric Micelles
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Author : Morteza Rasoulianboroujeni
language : en
Publisher:
Release Date : 2023
New Insights Into The Fabrication Of Drug Loaded Polymeric Micelles written by Morteza Rasoulianboroujeni and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
This study aimed to develop a safe and scalable method for fabricating drug-loaded polymeric micelles while addressing the challenges of long-term storage. Current fabrication methods present serious challenges in the development procedure, including the utilization of toxic solvents, the requirement for specialized equipment, and difficulties in solid form production. We hypothesized that by utilizing low molecular weight PEGs, known for their ability to dissolve hydrophobic drugs at elevated temperatures, as an alternative solvent, these challenges could be overcome in the production of drug-loaded micelles.We first focused on investigating micelle formation in a copolymer/PEG/water mixture using a model based on mean-field lattice theory. The model considered the free energy and translational entropy of the micelles, revealing the existence of entropy-driven liquid-liquid phase separation (LLPS) preceding micelle formation. This event can be controlled by varying the degree of polymerization. Experimental validation confirmed the accuracy of the model using PEG4kDa-b-PLA2.2kDa as the copolymer and PEG as the solvent. Building on this system, we introduced the "PEG-assist" method for fabricating drug-loaded polymeric micelles by hydrating a mixture of PEG, copolymer, and drug. The properties of the resulting micelles were influenced by the molecular weight of PEG and temperature, both areknown to impact LLPS and solvation power of PEG. The method's adaptability to other drugs and copolymers, scalability, freeze-drying feasibility, and stability were also proved. Furthermore, we proposed a formulation strategy for producing drug-loaded polymeric micelles directly from solid drug-loaded copolymer crystals. The crystals formed through crystallization from a supersaturated solution of the copolymer and drug in low molecular weight PEG. Parameters like PEG molecular weight and crystallization conditions were found to impact the formation of drug-loaded micelles through hydration and the properties of the resulting micelles. In summary, this study presents a comprehensive approach for fabricating drug-loaded polymeric micelles from a physical chemistry perspective, providing alternatives to current fabrication methods.
Polymer Modification
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Author : John Meister
language : en
Publisher: CRC Press
Release Date : 2000-07-25
Polymer Modification written by John Meister and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-07-25 with Science categories.
"Describes new modification methods and applications for natural, synthetic, thermoplastic, and thermoset polymers that result from economic forces, commercial processes, and the latest research and development. Features chemical and physical technologies such as sulfonation, alkylation, acid/base hydrolysis, hydrogenation, stress orienting, anneal
Biogenic Nanomaterials For Environmental Sustainability Principles Practices And Opportunities
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Author : Maulin P. Shah
language : en
Publisher: Springer Nature
Release Date : 2024-01-03
Biogenic Nanomaterials For Environmental Sustainability Principles Practices And Opportunities written by Maulin P. Shah and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-03 with Science categories.
Environmental pollution is a worldwide concern now. A major section of the world population is struggling for drinking water. Polluted soil is resulting into low agricultural productivity and thus creating challenges in the way of sustainable livelihood of a large section of human population. Biological treatment can offer both green solutions for wastewater treatment and resource recovery as well. Like algal-based systems can be utilized for wastewater treatment and production of biofuels from the biomass grown on the wastewater. Bio-based nanomaterials have been extensively studied for their employability in the health care, process optimization, water resource management, dealing with environmental pollutants, biosensors, and many others. Bioprospecting of novel biological agents, bio-based products, and bioresource recovery are paving the way for sustainable development as they are providing local solutions for a number of problems. In this proposed book, we start with the introduction to bio-nanotechnological principles and later on discuss bio-based nanomaterials employability for a diverse range of applications from environment to energy to health care. This book provides with current trends in bio-nanotechnology for anthropogonic purposes, prospects, challenges, and way forward.
Chemically Tailored Polymeric Micelles For Drug Delivery
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Author : Monica L. Adams
language : en
Publisher:
Release Date : 2003
Chemically Tailored Polymeric Micelles For Drug Delivery written by Monica L. Adams and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Drug carriers (Pharmacy) categories.
Surfactant Science
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Author : Steven John Abbott
language : en
Publisher:
Release Date : 2017
Surfactant Science written by Steven John Abbott and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Emulsions categories.
A concise and practical reference for understanding surfactant systems Offers original formulas and phase diagrams for improved surfactant design and performance¿ Equations related to online computer apps allow readers to test their own data Written in a conversational form, with a focus on real-world problems and troubleshooting Applications to detergents, coatings, cosmetics, soil and water remediation, and biosurfactants Full chapter included on foam and anti-foam science
Compendium Of Polymer Terminology And Nomenclature
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Author : Richard G Jones
language : en
Publisher: Royal Society of Chemistry
Release Date : 2009-01-19
Compendium Of Polymer Terminology And Nomenclature written by Richard G Jones and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-19 with Science categories.
The IUPAC system of polymer nomenclature has aided the generation of unambiguous names that re ect the historical development of chemistry. However, the explosion in the circulation of information and the globalization of human activities mean that it is now necessary to have a common language for use in legal situations, patents, export-import regulations, and environmental health and safety information. Rather than recommending a ‘unique name’ for each structure, rules have been developed for assigning ‘preferred IUPAC names’, while continuing to allow alternatives in order to preserve the diversity and adaptability of nomenclature. Compendium of Polymer Terminology and Nomenclature is the only publication to collect the most important work on this subject into a single volume. It serves as a handy compendium for scientists and removes the need for time consuming literature searches. One of a series issued by the International Union of Pure and Applied Chemistry (IUPAC), it covers the terminology used in many and varied aspects of polymer science as well as the nomenclature of several di erent types of polymer including regular and irregular single-strand organic polymers, copolymers and regular double-strand (ladder and spiro) organic polymers.
Fundamental Principles Of Polymeric Materials
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Author : Stephen L. Rosen
language : en
Publisher: Wiley-Interscience
Release Date : 1993
Fundamental Principles Of Polymeric Materials written by Stephen L. Rosen and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Science categories.
Expanded discussion of extended-chain crystals and their commercial developments; phase behavior in polymer-solvent systems; and three-dimensional stress and strain introduction to the Flory-Huggins theory; the "modified Cross" model; and Tobolsky's "Procedure X" for extracting discrete relaxation times and moduli from data. New sections on scaleup calculations for the laminar flow of non-Newtonian fluids; liquid-crystal polymers; and group-transfer polymerization, including a quantitative treatment of Ziegler-Natta polymerization with worked-out examples. All kinetic expressions are written in terms of conversions (rather than monomer concentration) for greater generality and ease of application. Kinetic expressions incorporate the possibility of a variable-volume reaction mass, and feature new examples to illustrate the effects of variable volume.
Principles Of Polymerization
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Author : George Odian
language : en
Publisher: John Wiley & Sons
Release Date : 2004-02-09
Principles Of Polymerization written by George Odian and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-09 with Technology & Engineering categories.
The new edition of a classic text and reference The large chains of molecules known as polymers are currently used in everything from "wash and wear" clothing to rubber tires to protective enamels and paints. Yet the practical applications of polymers are only increasing; innovations in polymer chemistry constantly bring both improved and entirely new uses for polymers onto the technological playing field. Principles of Polymerization, Fourth Edition presents the classic text on polymer synthesis, fully updated to reflect today's state of the art. New and expanded coverage in the Fourth Edition includes: * Metallocene and post-metallocene polymerization catalysts * Living polymerizations (radical, cationic, anionic) * Dendrimer, hyperbranched, brush, and other polymer architectures and assemblies * Graft and block copolymers * High-temperature polymers * Inorganic and organometallic polymers * Conducting polymers * Ring-opening polymer ization * In vivo and in vitro polymerization Appropriate for both novice and advanced students as well as professionals, this comprehensive yet accessible resource enables the reader to achieve an advanced, up-to-date understanding of polymer synthesis. Different methods of polymerization, reaction parameters for synthesis, molecular weight, branching and crosslinking, and the chemical and physical structure of polymers all receive ample coverage. A thorough discussion at the elementary level prefaces each topic, with a more advanced treatment following. Yet the language throughout remains straightforward and geared towards the student. Extensively updated, Principles of Polymerization, Fourth Edition provides an excellent textbook for today's students of polymer chemistry, chemical engineering, and materials science, as well as a current reference for the researcher or other practitioner working in these areas.