Next Generation Linkage Analysis
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Next Generation Linkage Analysis
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Author : Veronica J. Vieland
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2011
Next Generation Linkage Analysis written by Veronica J. Vieland and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Human genetics categories.
With the advent of affordable high-throughput genetic sequence, the human genetics community is returning to a focus on family data. Sequencing family members can facilitate data cleaning by identifying non-Mendelizing putative variants. It can provide a powerful mechanism for discerning the relevant sequence variants, by focusing on those segregating with the phenotype of interest. By the same token, sequencing holds out the possibility of capitalizing on earlier gene localization findings based on analyses of family data - findings that have provided numerous tantalizing loci for a wide range of complex phenotypes, but to date have resulted in relatively little definitive identifications of specific causal genes. This special issue of 'Human Heredity' is intended to showcase some of the advances in the statistical and computational technologies now available for linkage analysis. As the field returns to an appreciation of the power of linkage analysis, the collection of papers will convey the flavor of what is now possible. Human geneticists and scientists involved in gene mapping studies will gather information on new methods and computer programs available for linkage analysis to parallel sequencing experiments.
Encyclopedia Of Bioinformatics And Computational Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2018-08-21
Encyclopedia Of Bioinformatics And Computational Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-21 with Medical categories.
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases
Advances In The Understanding Of Biological Sciences Using Next Generation Sequencing Ngs Approaches
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Author : Gaurav Sablok
language : en
Publisher: Springer
Release Date : 2015-07-16
Advances In The Understanding Of Biological Sciences Using Next Generation Sequencing Ngs Approaches written by Gaurav Sablok and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-16 with Science categories.
Provides a global view of the recent advances in the biological sciences and the adaption of the pathogen to the host plants revealed using NGS. Molecular Omic’s is now a major driving force to learn the adaption genetics and a great challenge to the scientific community, which can be resolved through the application of the NGS technologies. The availability of complete genome sequences, the respective model species for dicot and monocot plant groups, presents a global opportunity to delineate the identification, function and the expression of the genes, to develop new tools for the identification of the new genes and pathway identification. Genome-wide research tools, resources and approaches such as data mining for structural similarities, gene expression profiling at the DNA and RNA level with rapid increase in available genome sequencing efforts, expressed sequence tags (ESTs), RNA-seq, gene expression profiling, induced deletion mutants and insertional mutants, and gene expression knock-down (gene silencing) studies with RNAi and microRNAs have become integral parts of plant molecular omic’s. Molecular diversity and mutational approaches present the first line of approach to unravel the genetic and molecular basis for several traits, QTL related to disease resistance, which includes host approaches to combat the pathogens and to understand the adaptation of the pathogen to the plant host. Using NGS technologies, understanding of adaptation genetics towards stress tolerance has been correlated to the epigenetics. Naturally occurring allelic variations, genome shuffling and variations induced by chemical or radiation mutagenesis are also being used in functional genomics to elucidate the pathway for the pathogen and stress tolerance and is widely illustrated in demonstrating the identification of the genes responsible for tolerance in plants, bacterial and fungal species.
Next Generation Sequencing And Whole Genome Selection In Aquaculture
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Author : Zhanjiang (John) Liu
language : en
Publisher: John Wiley and Sons
Release Date : 2010-12-01
Next Generation Sequencing And Whole Genome Selection In Aquaculture written by Zhanjiang (John) Liu and has been published by John Wiley and Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Technology & Engineering categories.
Recent developments in DNA marker technologies, in particular the emergence of Single Nucleotide Polymorphism (SNP) discovery, have rendered some of the traditional methods of genetic research outdated. Next Generation Sequencing and Whole Genome Selection in Aquaculture comprehensively covers the current state of research in whole genome selection and applies these discoveries to the aquaculture industry specifically. The text begins with a thorough review of SNP and transitions into topics such as next generation sequencing, EST data mining, SNP quality assessment, and whole genome selection principles. Ending with a discussion of the technology's specific applications to the industry, this text will be a valuable reference for those involved in all aspects of aquaculture research. Special Features: Unique linking of SNP technologies, next generation sequencing technologies, and whole genome selection in the context of aquaculture research Thorough review of Single Nucleotide Polymorphism and existing research 8-page color plate section featuring detailed illustrations
Next Generation Sequencing
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Author : Jerzy Kulski
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-01-14
Next Generation Sequencing written by Jerzy Kulski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-14 with Medical categories.
Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.
Analysis Of Genetic Association Studies
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Author : Gang Zheng
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-11
Analysis Of Genetic Association Studies written by Gang Zheng and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-11 with Medical categories.
Analysis of Genetic Association Studies is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in Analysis of Genetic Association Studies particularly relevant. The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology. In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications. Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge. The organization of this work allows for both casual reference and close study.
Applied Computational Genomics
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Author : Yin Yao Shugart
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-30
Applied Computational Genomics written by Yin Yao Shugart and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-30 with Medical categories.
"Applied Computational Genomics" focuses on an in-depth review of statistical development and application in the area of human genomics including candidate gene mapping, linkage analysis, population-based, genome-wide association, exon sequencing and whole genome sequencing analysis. The authors are extremely experienced in the area of statistical genomics and will give a detailed introduction of the evolution in the field and critical evaluations of the advantages and disadvantages of the statistical models proposed. They will also share their views on a future shift toward translational biology. The book will be of value to human geneticists, medical doctors, health educators, policy makers, and graduate students majoring in biology, biostatistics, and bioinformatics. Dr. Yin Yao Shugart is investigator in the Intramural Research Program at the National Institute of Mental Health, Bethesda, Maryland USA.
The Genetics And Development Of Scoliosis
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Author : Kenro Kusumi
language : en
Publisher: Springer
Release Date : 2018-06-12
The Genetics And Development Of Scoliosis written by Kenro Kusumi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with Medical categories.
Our understanding of the genetic and developmental mechanisms underlying scoliosis is rapidly evolving, this timely second edition of The Genetics and Development of Scoliosis is to provide researchers, clinicians, and students with the most current views in this field. This volume brings together leaders in understanding congenital and idiopathic scoliosis to present the current state of research, and to compare the genetic etiology of these conditions, in order to identify potential shared developmental mechanisms. This book will summarize the recent advances in studies of spinal development and how disruptions during embryogenesis in embryonic segmentation can lead to congenital vertebral defects. In addition, recent reports of genetic loci predisposing patients to develop juvenile and adolescent idiopathic scoliosis will be presented, and key clinical features are reviewed. Finally, there will be discussion of how genetic heterogeneity and gene-environment interactions may contribute to congenital scoliosis and isolated vertebral malformations.
Next Generation Sequencing Ngs For Rare Diseases Diagnosis Volume Ii
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Author : Xiu-An Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-31
Next Generation Sequencing Ngs For Rare Diseases Diagnosis Volume Ii written by Xiu-An Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with Science categories.
Next Generation Sequencing Based Clinical Molecular Diagnosis Of Human Genetic Disorders
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Author : Lee-Jun C. Wong
language : en
Publisher: Springer
Release Date : 2017-05-15
Next Generation Sequencing Based Clinical Molecular Diagnosis Of Human Genetic Disorders written by Lee-Jun C. Wong and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-15 with Science categories.
Next Generation Sequencing technology has been applied to clinical diagnoses in the past three to five years using various approaches, including target gene panels and whole exomes. The purpose of this book is to summarize the experiences, the results, advantages and disadvantages, along with future development in the area of NGS-based molecular diagnosis. This up-to-date volume will not only provide the readers working with Next Generation Sequencing the basics on how to apply the technology to molecular diagnosis, but will present the results and experience of practical application.