Ngf And Related Molecules In Health And Disease
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Ngf And Related Molecules In Health And Disease
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Author : L. Aloe
language : en
Publisher: Elsevier
Release Date : 2003-12-10
Ngf And Related Molecules In Health And Disease written by L. Aloe and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-10 with Science categories.
The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.
Recent Advances In Ngf And Related Molecules
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Author : Laura Calzà
language : en
Publisher: Springer
Release Date : 2021-09-10
Recent Advances In Ngf And Related Molecules written by Laura Calzà and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-10 with Medical categories.
More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
Recent Advances In Ngf And Related Molecules
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Author : Laura Calzà
language : en
Publisher:
Release Date : 2021
Recent Advances In Ngf And Related Molecules written by Laura Calzà and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
Recent Advances In Ngf And Related Molecules
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Author : Laura Calzà
language : en
Publisher: Springer Nature
Release Date : 2021-08-27
Recent Advances In Ngf And Related Molecules written by Laura Calzà and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-27 with Medical categories.
More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.
Neuroimmunology Research Focus
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Author : Paulo V. Broglio
language : en
Publisher: Nova Publishers
Release Date : 2007
Neuroimmunology Research Focus written by Paulo V. Broglio and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Nervous system categories.
Neuroimmunology is a rapidly-growing branch of biomedical science that studies of all aspects of the interactions between the immune system and nervous system. It deals with, among other things, the physiological functioning of the neuroimmune system in states of both health and disease; malfunctions of the neuroimmune system in disorders (autoimmune diseases, hypersensitivities, immune deficiency), the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo. Despite the brain's status as an immune privileged site, an extensive bi-directional communication takes place between the nervous and the immune system in both health and disease. Immune cells and neuroimmune molecules such as cytokines, chemokines, and growth factors modulate brain function through multiple signalling pathways throughout the lifespan. Immunological, physiological and psychological stressors engage cytokines and other immune molecules as mediators of interactions with neuroendocrine, neuropeptide, and neurotransmitter systems. For example, brain cytokine levels increase following stress exposure, while treatments designed to alleviate stress reverse this effect. This book presents leading research in the field.
Mouse Models Of Development And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-04-20
Mouse Models Of Development And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-20 with Science categories.
Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on Mouse Models of Development and Disease
Neuroblastoma
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Author : Nai-Kong V. Cheung
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-30
Neuroblastoma written by Nai-Kong V. Cheung and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Medical categories.
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Peptides In Energy Balance And Obesity
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Author : Gema Frühbeck
language : en
Publisher: CABI
Release Date : 2009
Peptides In Energy Balance And Obesity written by Gema Frühbeck and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Science categories.
The aim of this book is to provide an updated, detailed and comprehensive account of the field through a cutting-edge analysis by leading experts in the area. To achieve this, the book is divided into three parts, focusing on the peptides operating both centrally and peripherally at the same time as providing an integral and integrated perspective of the multifaceted and complex regulation of energy balance homeostasis. Part I contains three chapters covering the central pathways involved in the control of food intake. The first of these is devoted to the orexigenic neuropeptides, i.e. those that increase or stimulate appetite, while the second is a description of the peptides with anorexigenic effects, i.e. those that decrease or stop food intake. Since this is a rapidly evolving field, the third chapter concentrates on emerging and newly identified factors and their interaction with the already well-known peptides. Part II encompasses six chapters that deal with the peripheral signals participating in energy homeostasis and their control in health and disease. Regulation of body weight was once considered a simple feedback control system in which the hypothalamus modulated food intake and energy expenditure to compensate for fluctuations in body weight. The existing body of evidence has fostered the transition from the classic adipostat, a sensor of body adiposity that informs the hypothalamus about the abundance of energy stores, to a more dynamic and multifactorial model including signals emerging from several different organs such as the gut, the liver, the pancreas and the vascular system. The underlying molecular mechanisms by which adipose tissue enlargement and the subsequent increase in adipokines contribute to the pathophysiological events in the gastrointestinal, hepatic, pancreatic, musculoskeletal, cardiovascular and immune systems are now beginning to be better understood and are covered in detail in this section of the book. Part III contains six chapters providing an integrative approach to current knowledge in energy balance regulation. Adipose tissue biology and the hierarchy of the neural circuitry controlling energy homeostasis deserve special attention, as does the relevance of food reward signals and the links between the homeostatic and hedonic systems. Specific chapters address the available advances in technology to analyse these complex issues, including functional neuroimaging and the whole range of the 'omics' strategies. The final chapter takes a fresh and innovative look at future potential approaches to obesity management.
Pain Novel Targets And New Technologies
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Author : Susan Hua
language : en
Publisher: Frontiers Media SA
Release Date : 2015-01-22
Pain Novel Targets And New Technologies written by Susan Hua and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-22 with Analgesics categories.
The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. This e-Book “PAIN – novel targets and new technologies” has brought together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies across the various types of pain. This information is presented as novel research findings, short communications and review articles. The goal of this e-Book is to generate further collaborative discussion on the future and direction of pain therapies.
Nanoneuroscience And Nanoneuropharmacology
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Author : Hari S. Sharma
language : en
Publisher: Elsevier
Release Date : 2009-12-03
Nanoneuroscience And Nanoneuropharmacology written by Hari S. Sharma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-03 with Science categories.
This volume presents articles from the leading experts in the field in nanobiotechnology, providing students and researchers with a comprehensive review of the newly emerging area of neuroscience. All aspects of nanomaterials induced alteration in brain function are considered. Basic chapters on methods and ways to enhance nano-drug delivery into the brain are presented as well as chapters on functional and structural changes in the CNS, including gene expression and related issues. Particular attention is given to possible therapeutic advancement regarding nano-drug formulation and their role in neuroprotection.