Nitrates Iii
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Nitrates Iii
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Author : P. Lichtlen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nitrates Iii written by P. Lichtlen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. This is surprising in view of the fact that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gained into the pharmacology, pharmacokinetics and pharmacodynamics of nitrates, as well as into their clinical effects in acute and chronic ischemic heart diseases and in severe congestive heart failure. Relatively little progress, however, was observed in research into the basic action of nitrates. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined. In contrast, dose-dependent differences in venous and arteriolar tone have long been clearly established. Treatment was again in the main stream of discussion. The question of tolerance following long-term administration was discussed in depth and the term "pseudotolerance" was introduced to describe the adaptation of the body's circulatory system to chronic vasodilation. This is especially important in long term prophylactic antiischemic treatment in stable, as well as in unstable angina pectoris (i.e. during increased vasomotor tone - spasm).
Note On The Oxidation Of Pu Iii By Nitrate Ion
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Author : R. E. Connick
language : en
Publisher:
Release Date : 1946
Note On The Oxidation Of Pu Iii By Nitrate Ion written by R. E. Connick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1946 with Nitrates categories.
Polymorphic Changes Under Pressure Of The Univalent Nitrates
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Author : Percy Williams Bridgman
language : en
Publisher:
Release Date : 1916
Polymorphic Changes Under Pressure Of The Univalent Nitrates written by Percy Williams Bridgman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1916 with Crystallography categories.
Nitrate Ii
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Author : Werner Rudolph
language : en
Publisher:
Release Date : 1980
Nitrate Ii written by Werner Rudolph and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Cardiovascular agents categories.
Organic Nitrates
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Author : P. Needleman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Organic Nitrates written by P. Needleman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.
A Dictionary Of Chemistry And The Allied Branches Of Other Sciences
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Author : Henry Watts
language : en
Publisher:
Release Date : 1877
A Dictionary Of Chemistry And The Allied Branches Of Other Sciences written by Henry Watts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1877 with Chemistry categories.
A Dictionary Of Chemistry And The Allied Branches Of Other Sciences
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Author : Henry Watts (F.C.S.)
language : en
Publisher:
Release Date : 1877
A Dictionary Of Chemistry And The Allied Branches Of Other Sciences written by Henry Watts (F.C.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1877 with categories.
A Dictionary Of Chemistry And The Allied Branches Of Other Sciences V 4 1883
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Author : Henry Watts
language : en
Publisher:
Release Date : 1883
A Dictionary Of Chemistry And The Allied Branches Of Other Sciences V 4 1883 written by Henry Watts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1883 with categories.
Nitrates And Nitrate Tolerance In Angina Pectoris
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Author : M. Kaltenbach
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nitrates And Nitrate Tolerance In Angina Pectoris written by M. Kaltenbach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Although nitroglycerin is one of the oldest drugs in cardiology the problem of tolerance is a scientific challenge of today. The proceedings of this symposium highlight the most re cent questions related to this topic. Apparently, partial tolerance, or rather partial decrease in sensitivity, can arise during nitrate therapy. Probably this is the consequence of a partial readjustment of the vascular system. This readjustment refers particularly to the arterial system, i.e., to the hypoten sive effect of nitrates in the standing position. A similar effect on the venous side is not present. On the other hand, the results assembled in this volume confirm the experience of many decades that long-term antianginal therapy with nitrates remains effective even when high doses are applied. Thus partial tolerance which also occurs after other vasodilators such as prazosin, does not imply tolerance against antianginal effectiveness. From the information available to day it is reasonable to treat patients with angina pectoris acutely as well as chronically with nitrates in individually adjusted doses. Frankfurt, November 1982 M. Kaltenbach v Contents Foreword ... V Session 1-Pharmacology Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpoints N. Rietbrock, A. Lassmann, B.G. Woodcock ... 3 Does Tolerance Develop During Long-Acting Nitrate Therapy? A Critical Review J. Abrams ... 13 Pharmacokinetics of Isosorbide Dinitrate During Tolerance Development Ho-Leung Fung ... 25 Discussion ... . 29 ... Session II - Hemodynamics Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure Joseph A. Franciosa ... 35 Discussion ... 41 ...
Nitrates Nitrites And Methemoglobinemia
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Author : National Institute of Environmental Health Sciences
language : en
Publisher:
Release Date : 1970
Nitrates Nitrites And Methemoglobinemia written by National Institute of Environmental Health Sciences and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Children categories.