Nitric Oxide Donors
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Nitric Oxide Donors
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Author : Peng George Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2005-08-16
Nitric Oxide Donors written by Peng George Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-16 with Science categories.
Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.
Nitric Oxide Donors
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Author : Amedea Seabra
language : en
Publisher: Academic Press
Release Date : 2017-03-17
Nitric Oxide Donors written by Amedea Seabra and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-17 with Medical categories.
Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval
Endogenous And Therapeutic Nitric Oxide Donors
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Author : Thomas Felix Lüscher
language : en
Publisher:
Release Date : 1991
Endogenous And Therapeutic Nitric Oxide Donors written by Thomas Felix Lüscher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Blood-vessels categories.
Nitric Oxide Donor Induced In Chemosensitization
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Author : Benjamin Bonavida
language : en
Publisher: Academic Press
Release Date : 2017-06-28
Nitric Oxide Donor Induced In Chemosensitization written by Benjamin Bonavida and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-28 with Medical categories.
Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations
Nitric Oxide And The Cardiovascular System
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Author : Joseph Loscalzo
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-03-29
Nitric Oxide And The Cardiovascular System written by Joseph Loscalzo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-29 with Medical categories.
Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.
Nitric Oxide In Health And Disease
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Author : Lucia Morbidelli
language : en
Publisher: Elsevier
Release Date : 2023-04-13
Nitric Oxide In Health And Disease written by Lucia Morbidelli and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-13 with Computers categories.
Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases Encompasses real-world examples of recent research related to NO and cancer
Therapeutic Application Of Nitric Oxide In Cancer And Inflammatory Disorders
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Author : Lucia Morbidelli
language : en
Publisher: Academic Press
Release Date : 2019-02-09
Therapeutic Application Of Nitric Oxide In Cancer And Inflammatory Disorders written by Lucia Morbidelli and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-09 with Medical categories.
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
Shock Sepsis And Organ Failure Nitric Oxide
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Author : Günther Schlag
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Shock Sepsis And Organ Failure Nitric Oxide written by Günther Schlag and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
International experts examine the role of nitric oxide in various metabolic events such as septic shock, cardiovascular dysfunction, and trauma and hemorrhagic shock. The nitric oxide pathway and nitric oxide synthesis regulation are also discussed.
Functionalised Cardiovascular Stents
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Author : Gerard Wall
language : en
Publisher: Woodhead Publishing
Release Date : 2018-02-06
Functionalised Cardiovascular Stents written by Gerard Wall and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-06 with Medical categories.
Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. Provides a specific focus on cardiovascular stents Includes a range of topics covering the fundamentals, surface modification and biofunctionalization Provides essential knowledge for researchers on advances in the field
Management Of Chronic Musculoskeletal Conditions In The Foot And Lower Leg
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Author : Keith Rome
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-09-18
Management Of Chronic Musculoskeletal Conditions In The Foot And Lower Leg written by Keith Rome and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-18 with Medical categories.
Bridging the gap between undergraduate and postgraduate knowledge and experience, this new full colour resource uses an interdisciplinary approach to help manage chronic conditions – osteoarthritis, Achilles tendinopathy, gout, rheumatic diseases, forefoot/rearfoot entities, stress fractures/reactions, cerebral palsy – in the lower limb and foot. Each chapter includes sections on predisposing factors, diagnosis, impairments, function, quality of life and management strategies while highlighting any complex features of a condition which may present. The latest advances are discussed with suggestions for new paths of research – ‘future directions’. The text is further supported by additional commentaries from internationally renowned researchers who highlight the key elements of the work and provide a supplementary perspective of the particular clinical condition. A general view of the patient’s needs is offered throughout, connecting clinical realities to real-world patient experiences. Management of Chronic Conditions in the Foot and Lower Leg is a comprehensive, practical tool that can be used to inform daily decision making in practice as well as to support those who build policy and management strategies in the clinical areas covered. Clear content and structure supported by full colour illustrations Includes less discussed conditions such as gout and cerebral palsy Focus on pain, impairment, function, quality of life and management strategies Critical reflections by experts highlight current clinical practice and thinking in research Provides a sound interpretation of research findings Features patient-reported outcome measures and health related behaviour strategies