Nitric Oxide And The Cardiovascular System
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Nitric Oxide And The Cardiovascular System
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Author : Joseph Loscalzo
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-03-29
Nitric Oxide And The Cardiovascular System written by Joseph Loscalzo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-29 with Medical categories.
Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.
Reactive Oxygen Species And The Cardiovascular System
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Author : Augusto C. Montezano
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2012
Reactive Oxygen Species And The Cardiovascular System written by Augusto C. Montezano and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
Reactive oxygen species (ROS) influence various physiological processes including host defense, hormone biosynthesis, and cellular signaling. Increased ROS production (oxidative stress) is implicated in many diseases of the cardiovascular system, including hypertension, atherosclerosis, cardiac failure, stroke, diabetes, and kidney disease. ROS are produced throughout the cardiovascular system, in the kidney and central and peripheral nervous system. A major source for cardiovascular, renal, and neural ROS is a family of non-phagocytic NAD(P)H oxidases, including the prototypic Nox2 homologue-based NAD(P)H oxidase, as well as other NAD(P)H oxidases, such as Nox1 and Nox4. Other possible sources include mitochondrial electron transport enzymes, xanthine oxidase, cyclooxygenase, lipoxygenase, and uncoupled nitric oxide synthase (NOS). NAD(P)H oxidase-derived ROS is important in regulating endothelial function and vascular tone and oxidative stress is implicated in endothelial dysfunction, inflammation, hypertrophy, apoptosis, migration, fibrosis, angiogenesis and rarefaction, important processes involved in vascular remodeling in cardiovascular disease. These findings have evoked considerable interest because of the possibilities that therapies targeted against non-phagocytic NAD(P)H oxidase to decrease ROS generation and/or strategies to increase nitric oxide (NO) availability and antioxidants may be useful in minimizing vascular injury and thereby prevent or regress target organ damage associated with hypertension and other cardiovascular diseases.
No More Heart Disease
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Author : Louis Ignarro
language : en
Publisher: St. Martin's Press
Release Date : 2006-01-24
No More Heart Disease written by Louis Ignarro and has been published by St. Martin's Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-24 with Health & Fitness categories.
Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well. NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor. The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.
The Role Of Nitric Oxide In Heart Failure
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Author : Bodh I. Jugdutt
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08
The Role Of Nitric Oxide In Heart Failure written by Bodh I. Jugdutt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Medical categories.
Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.
Nitric Oxide And The Regulation Of The Peripheral Circulation
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Author : Philip J. Kadowitz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nitric Oxide And The Regulation Of The Peripheral Circulation written by Philip J. Kadowitz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Haemodynamic Effects Of Nitric Oxide
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Author : Robert T Mathie
language : en
Publisher: World Scientific
Release Date : 1999-08-30
The Haemodynamic Effects Of Nitric Oxide written by Robert T Mathie and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-30 with Science categories.
Since the discovery of nitric oxide as an endothelium-derived relaxing factor in 1987, investigations on its precise modes of action have been carried out at an extraordinary rate. Nitric oxide is now implicated in many physiological and pathological processes — not just in the control of vascular resistance, but in nerve transmission, cell proliferation, inflammatory responses and so on. Despite such rapid progress, no attempt has been made to combine the current knowledge of this subject matter in a single textbook. This volume has been written with the above in mind and presents a topical, comprehensive overview of the biochemistry and the physiological and pathophysiological effects of nitric oxide as they relate to the cardiovascular system. The therapeutic implications of nitric oxide are also considered. The text comprises contributions from many of the leading international authorities on the topic including Professor L J Ignarro, winner of the 1998 Nobel Prize in Physiology or Medicine. Contents:Physiology and Biochemistry of Nitric Oxide:Chemistry and Molecular Biology of Nitric Oxide Synthesis (A J Hobbs & L J Ignarro)Nitric Oxide Synthases Biology: Insights Gained from ‘Knockout’ Mice (A Papapetropoulos et al.)Inhibitors of Nitric Oxide Biosynthesis (G J Southan et al.)Peripheral Vascular Effects of Nitric Oxide:The Role of Nitric Oxide in Cerebrovascular Regulation and Stroke (C Iadecola)The Physiological and Pathophysiological Effects of Nitric Oxide in the Coronary Circulation (P Groves)The Effect of Nitric Oxide on Myocardial Function and Dysfunction (B D Prendergast & A M Shah)Clinical Implications of Nitric Oxide:Oxidative Tissue Injury, Nitric Oxide and Atherosclerosis (R P Patel et al.)Endothelial Dysfunction Associated with Cardiovascular Disease and Transplantation (G J Dusting & A M Dart)The Role and Therapeutic Implications of Nitric Oxide in Systemic Hypertension (P Forte & N Benjamin)and other papers Readership: Students and researchers in physiology, biochemistry and clinical methods/ laboratory medicine. Keywords:Endothelium;Vascular Smooth Muscle;Nitric Oxide Synthase;Nitrovasodilator;Shear Stress;Atherosclerosis;Hypertension;Septic Shock;Microcirculation;Coronary Circulation;Cerebal Circulation;Renal Circulation;Hepatic Circulation;Intestinal Circulation
Pathophysiology And Clinical Applications Of Nitric Oxide
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Author : Gabor M. Rubanyi
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Pathophysiology And Clinical Applications Of Nitric Oxide written by Gabor M. Rubanyi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.
Carbon Monoxide And Cardiovascular Functions
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Author : Rui Wang
language : en
Publisher: CRC Press
Release Date : 2001-10-30
Carbon Monoxide And Cardiovascular Functions written by Rui Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-30 with Medical categories.
Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive
Nitric Oxide In Health And Disease
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Author : Jill Lincoln
language : en
Publisher: Cambridge University Press
Release Date : 1997-08-28
Nitric Oxide In Health And Disease written by Jill Lincoln and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-08-28 with Medical categories.
Nitric oxide has a tantalizing role in health and disease: while many of its wide-ranging effects are well known, there remains much more to explore and to learn about the interactions of this fascinating molecule in physiological and pathophysiological processes. The volume reviews the myriad effects of nitric oxide as a chemical messenger in the central nervous system, peripheral nervous system, immune system and cardiovascular system. Furthermore, it provides a very practical introduction to the procedures and experimental protocols necessary to work with and study nitric oxide and its synthesizing enzyme, nitric oxide synthase, in the laboratory. In this respect the volume is unique, providing as it does a complete single-volume review of the role of nitric oxide in health and disease, and a very practical introduction to the methods and protocols involved in this intriguing and active area of biomedical research.
Nitric Oxide
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Author : Louis J. Ignarro
language : en
Publisher: Academic Press
Release Date : 2000-09-13
Nitric Oxide written by Louis J. Ignarro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-13 with Science categories.
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense