Non Coding Rnas In The Vasculature
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Non Coding Rnas In The Vasculature
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Author : Thomas Thum
language : en
Publisher: Springer
Release Date : 2017-03-15
Non Coding Rnas In The Vasculature written by Thomas Thum and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Medical categories.
This book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology.
Non Coding Rnas In Cardiovascular Diseases
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Author : Junjie Xiao
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Non Coding Rnas In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Science categories.
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
The Role Of Non Coding Rnas In Vascular Damage In Hypertension And Ckd
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Author : Kugeng Huo
language : en
Publisher:
Release Date : 2018
The Role Of Non Coding Rnas In Vascular Damage In Hypertension And Ckd written by Kugeng Huo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
"Hypertension and chronic kidney disease (CKD) are two of the most prevalent global health concerns that account for millions of deaths per year. They are both associated with vascular damage that is characterized by vascular remodeling and stiffening, as well as endothelial dysfunction, which contribute to further development of the disease and lead to end organ damage. MicroRNAs (miRNAs) are important non-coding RNA regulators of gene expression that cause translational repression and transcript degradation upon binding to their target mRNAs. miRNAs have been demonstrated to be associated with hypertension and CKD, and play a critical role in vascular cell development and function. However, their role in vascular damage is still poorly studied. We hypothesized that vascular and circulating miRNAs are dysregulated in hypertension and CKD; the dysregulation of vascular miRNAs is a key driving force of pathological gene expression changes that contribute to vascular damage; key dysregulated vascular miRNAs are potential therapeutic targets and key dysregulated circulating miRNAs are potential biomarkers for vascular damage in hypertension and CKD. The thesis contains 3 studies testing our hypotheses.In the first study, we profiled miRNAs using RNA sequencing in mesenteric arteries of mice infused or not with angiotensin (Ang) II for 7 or 14 days. We observed that both 7-day and 14-day Ang II infusion induced blood pressure (BP) elevation, oxidative stress and vascular stiffening, whereas only 14-day Ang II-infusion caused endothelial dysfunction and vascular remodeling. Using a candidate approach, we have identified miR-431-5p and its target Ets Homologous Factor (Ehf) as key regulators in Ang II-induced hypertension and vascular damage. miR-431-5p and Ehf were up- and down-regulated by 14-day Ang II-infusion, respectively, and were both correlated with BP. We demonstrated that miR-431-5p targets EHF in human aortic vascular smooth muscle cells, where EHF down-regulates collagen type I alpha 1 chain (Col1a1), and miR-382-5p. Intravenous injection of miR-431-5p inhibitors down-regulated miR-431-5p, Col1a1 and miR-382-5p, and up-regulated Ehf in mesenteric arteries, delayed BP elevation and reduced vascular damage in mice infused with Ang II for 14 days.In the second study, we profiled miRNAs as above but this time in small arteries dissected from subcutaneous gluteal biopsies performed in normotensive, hypertensive and CKD subjects to identify differentially expressed vascular miRNAs. Combined with the data from the first study, we found a common miRNA, miR-145-3p, that was down-regulated in both 7-day Ang II-infused mice and CKD patients. Whether miR-145-3p mediates vascular damage in Ang II-induced hypertension model and CKD remains to be elucidated.In the third study, we profiled circulating miRNAs from plasma of the same cohort of normotensive hypertensive and CKD subjects as in the second study. We identified and validated 4 differentially expressed miRNAs, let-7g-5p, miR-26a-5p, miR-191-5p and let-7b-5p, among which let-7g-5p was correlated with estimated glomerular filtration rate. We also found a correlation between circulating let-7g-5p and genes that were differentially expressed in small arteries of CKD patients.To summarize, miR-431-5p and its target Ehf are potential important regulators in the pathophysiology of vascular damage in hypertension, and may serve as novel therapeutic targets in the clinic. miR-145-3p may play a role in the development of Ang II-induced and CKD-associated vascular injury. Let-7g-5p has potential clinical value to serve as a biomarker for vascular damage in CKD." --
Understanding The Role Of Long Non Coding Rna Lncrna In Vascular Pathology
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Author : Margaret Ballantyne
language : en
Publisher:
Release Date : 2017
Understanding The Role Of Long Non Coding Rna Lncrna In Vascular Pathology written by Margaret Ballantyne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Atherosclerosis categories.
Non Coding Rna And Coronary Artery Disease
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Author : En-Zhi Jia
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-18
Non Coding Rna And Coronary Artery Disease written by En-Zhi Jia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-18 with Medical categories.
Long Non Coding Rna Fingerprint Regulated By Cyclic Mechanical Stress In Vascular Smooth Muscle Cells
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Author : Laura-Eve Mantella
language : en
Publisher:
Release Date : 2016
Long Non Coding Rna Fingerprint Regulated By Cyclic Mechanical Stress In Vascular Smooth Muscle Cells written by Laura-Eve Mantella and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Long noncoding RNAs (lncRNAs) are a new class of noncoding RNA and emerging evidence suggests that they represent a cellular hub for coordination of various cellular processes involved in health and disease. We hypothesized that lncRNAs may be involved in mechanical stretch-induced alterations in human aortic smooth muscle cells (HASMCs), which play a critical role in the pathophysiology of aneurysms and hypertension. Transcriptome analysis was performed on HASMCs that had been subjected to mechanical stretch. Human long intergenic non-coding RNA-p21 (hLincRNA-p21) was found to be significantly up-regulated in stretched HASMCs as well as in aneurysmal samples from patients undergoing aortic valve replacement (both P.
Non Coding Rnas At The Cross Road Of Cardiometabolic Diseases And Cancer
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Author : Paul Holvoet
language : en
Publisher: Springer Nature
Release Date : 2021-03-26
Non Coding Rnas At The Cross Road Of Cardiometabolic Diseases And Cancer written by Paul Holvoet and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-26 with Medical categories.
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
Non Coding Rna Based Therapeutics And Biomarkers For Treatment And Detection Of Vascular Disease
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Author : Greg Winski
language : en
Publisher:
Release Date : 2021
Non Coding Rna Based Therapeutics And Biomarkers For Treatment And Detection Of Vascular Disease written by Greg Winski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
The Identification Of Non Protein Coding Rna In The Tumour Vasculature
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Author : Klarke Michael Sample
language : en
Publisher:
Release Date : 2016
The Identification Of Non Protein Coding Rna In The Tumour Vasculature written by Klarke Michael Sample and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Understanding The Role Of The Long Non Coding Rna Mir503hg In Endothelial To Mesenchymal Transition During Vascular Remodelling
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Author : João Pedro Pinho Monteiro
language : en
Publisher:
Release Date : 2020
Understanding The Role Of The Long Non Coding Rna Mir503hg In Endothelial To Mesenchymal Transition During Vascular Remodelling written by João Pedro Pinho Monteiro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.