Non Coding Rna And Coronary Artery Disease
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Non Coding Rna And Coronary Artery Disease
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Author : En-Zhi Jia
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-18
Non Coding Rna And Coronary Artery Disease written by En-Zhi Jia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-18 with Medical categories.
Non Coding Rnas In Cardiovascular Diseases
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Author : Junjie Xiao
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Non Coding Rnas In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Science categories.
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Non Coding Rnas In The Vasculature
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Author : Thomas Thum
language : en
Publisher: Springer
Release Date : 2017-03-15
Non Coding Rnas In The Vasculature written by Thomas Thum and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Medical categories.
This book focuses on the importance of regulatory RNAs in the vasculature. The main topics discussed include the role of regRNAs in vascular development and angiogenesis, ischemic cardiovascular disease and repair mechanisms, diabetic and metabolic vascular disease, atherosclerosis and vascular inflammation, as well as diagnostics of vascular disease using circulating miRNAs. Lastly, it offers an overview of emerging topics such as microvesicle-mediated miRNA cellular trafficking and the vascular importance of long non-coding RNAs. It is an invaluable resource for academics, researchers and students working in the field of vascular biology.
Biomarkers In Cardiovascular Disease
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Author : Vijay Nambi
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-11-27
Biomarkers In Cardiovascular Disease written by Vijay Nambi and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-27 with Medical categories.
Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today’s available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Elucidating The Roles And Mechanisms By Which A Long Non Coding Rna Anril Regulates Endothelial Cell Activities In The Development Of Coronary Artery Disease
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Author : Hyosuk Cho
language : en
Publisher:
Release Date : 2021
Elucidating The Roles And Mechanisms By Which A Long Non Coding Rna Anril Regulates Endothelial Cell Activities In The Development Of Coronary Artery Disease written by Hyosuk Cho and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Coronary heart disease categories.
Coronary artery disease (CAD) is the leading cause of death worldwide. CAD is caused by atherosclerosis in the coronary arteries, and genetic factors are critical to the development of CAD. Although genome-wide association studies emphasized the importance of 9p21.3 locus as the first and most robust locus of CAD, the causal genes at this locus and their molecular mechanisms remain to be identified. In our studies with the long non-coding RNA gene, ANRIL, located within the 9p21.3 locus, we focused on the trafficking of monocytes across the endothelium, the critical cellular processes of CAD. First, we highlight our key findings that overexpression of the most abundant transcript of ANRIL, DQ485454, significantly reduces the trafficking of monocytes. In contrast, siRNA-mediated ANRIL knockdown (KD) has the opposite effect by modulating the expression levels of CLIP1, EZR, and LYVE1. Although microarray and follow-up quantitative RT-PCR analyses revealed multiple downstream genes of ANRIL, our mechanistic studies demonstrated that overexpression of CLIP1, EZR, and LYVE1 reversed the effects of ANRIL KD on trafficking of monocytes. Next, we further describe our discovery that ANRIL KD upregulates the expression of TMEM106B genes. Mechanistic studies disclosed that KD of TMEM106B reversed the effects of ANRIL KD on monocyte trafficking. Furthermore, the decreased trafficking of monocytes induced by ANRIL overexpression was fully reversed by overexpressing TMEM106B, which shows that TMEM106B is a necessary player in changing the cell processes that lead to CAD. Interestingly, we found that genomic variants in TMEM106B are highly associated with CAD, and significant gene-gene interaction was detected between rs2383207 in ANRIL and rs3807865 in TMEM106B, which suggests that ANRIL regulates EC functions by modulating TMEM106B expression. We further report that the two major splice variants of ANRIL, DQ485454 and NR_003529, demonstrate antagonizing effects on the endothelial cell activities associated with CAD. Modulating the expression level of the transcripts in the opposite direction maximized the observed changes in cellular activities we acquired in the previous studies. The transcripts also demonstrated expression regulation of the key downstream genes of ANRIL in the opposite direction. Altogether, these data suggest that ANRIL is the causal gene for CAD at the 9p21.3 locus that regulates EC functions directly related to CAD, and provide in vitro evidence that splice variants of ANRIL are the essential components of the gene in modulating the CAD risk by regulating the expression of the downstream genes, CLIP1, EZR, LYVE1, and TMEM106B.
Long Non Coding Rna
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Author : Syed Mudasir Andrabi
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2020-09-03
Long Non Coding Rna written by Syed Mudasir Andrabi and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-03 with Science categories.
Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.
An Investigation Into The Relationships Between Novel Y Chromosome Linked Long Non Coding Rnas And Coronary Artery Disease
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Author : Elsa Molina
language : en
Publisher:
Release Date : 2016
An Investigation Into The Relationships Between Novel Y Chromosome Linked Long Non Coding Rnas And Coronary Artery Disease written by Elsa Molina and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Blood-vessels categories.
"Background: Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality globally. However, the pathogenesis of CAD is still poorly understood. Previous studies have shown that genetic variation within the Y chromosome is associated with an increased risk of developing CAD independent of traditional cardiovascular risk factors; possibly through a modulating effect of an adaptive immunity and inflammatory response by macrophages in men. Long non-coding RNAs (lncRNAs) have recently gained focused attention as a new class of regulatory RNA molecules involved in cardiovascular function and associated disease, particularly long intergenic non-coding RNAs (lincRNAs), the largest class of lncRNA described so far. To date, Y chromosome-linked lincRNAs are poorly characterised and the potential link between these RNAs and CAD in men has not been investigated. Aims: The aim of this study is to better understand the potential function of novel Y-linked lincRNAs in men, especially in white blood cells (WBCs) as an effector tissue for CAD. Methods: From the first reference catalogue on human Y chromosomelinked lincRNAs, primers for nine Y-linked lincRNA transcripts (lnc-KDM5D-4:1, lnc- ZFY-1:1, lnc-ZFY-1:3, lnc-ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4, lnc-RBMY1J- 1:1, lnc-RBMY1J-1:2 and lnc-RBMY1J-1:3) were designed using the web-based tool Primer-BLAST from the DNA template sequence available on the LNCipedia, the first database with annotated human Y-linked lncRNAs [in January 2013]. Then, the lincRNA transcripts were analysed by quantitative PCR (qPCR) for differential expression in WBCs 49 from healthy men and in a tissue panel of 20 different normal, human tissues. Results: PCR primers for Y-linked lincRNAs were able to be designed from the DNA template sequence, and qPCR analysis identified distinct tissue-specific expression profiles. The Y chromosome-linked lincRNA transcripts lnc-KDM5D-4:1, lnc-ZFY-1:1, lnc-ZFY-1:3, lnc- ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4 and lnc-RBMY1J-1:3 were found to be expressed in WBCs in healthy men. Conclusion: This is the first study to use gene expression analysis to characterise the expression of Y-linked lincRNAs in humans by providing an expression pattern for the Y-linked lincRNA transcripts, lnc-KDM5D-4:1, lnc-ZFY-1:1, lnc-ZFY-1:3, lnc-ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4, lnc- RBMY1J-1:1, lnc-RBMY1J-1:2 and lnc-RBMY1J-1:3, across 20 human healthy tissues and in blood. Finally, the Y-linked lincRNA transcripts lnc-KDM5D-4:1, lnc-ZFY-1:1, lnc- ZFY-1:3, lnc-ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4, and lnc-RBMY1J-1:3 should be further studied, especially in WBCs such as macrophages, as they could be potential candidates for CAD."--Abstract.
Long Non Coding Rnas In Human Disease
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Author : Kevin V. Morris
language : en
Publisher: Springer
Release Date : 2016-04-13
Long Non Coding Rnas In Human Disease written by Kevin V. Morris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-13 with Medical categories.
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Non Coding Rnas At The Cross Road Of Cardiometabolic Diseases And Cancer
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Author : Paul Holvoet
language : en
Publisher: Springer Nature
Release Date : 2021-03-26
Non Coding Rnas At The Cross Road Of Cardiometabolic Diseases And Cancer written by Paul Holvoet and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-26 with Medical categories.
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
Small Extracellular Vesicle Associated Long Noncoding Rna Punisher As A Novel Plasma Based Biomarker In Coronary Artery Disease
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Author : Qian Li
language : en
Publisher:
Release Date : 2019
Small Extracellular Vesicle Associated Long Noncoding Rna Punisher As A Novel Plasma Based Biomarker In Coronary Artery Disease written by Qian Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.