An Investigation Into The Relationships Between Novel Y Chromosome Linked Long Non Coding Rnas And Coronary Artery Disease
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An Investigation Into The Relationships Between Novel Y Chromosome Linked Long Non Coding Rnas And Coronary Artery Disease
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Author : Elsa Molina
language : en
Publisher:
Release Date : 2016
An Investigation Into The Relationships Between Novel Y Chromosome Linked Long Non Coding Rnas And Coronary Artery Disease written by Elsa Molina and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Blood-vessels categories.
"Background: Coronary artery disease (CAD) is one of the leading causes of morbidity and mortality globally. However, the pathogenesis of CAD is still poorly understood. Previous studies have shown that genetic variation within the Y chromosome is associated with an increased risk of developing CAD independent of traditional cardiovascular risk factors; possibly through a modulating effect of an adaptive immunity and inflammatory response by macrophages in men. Long non-coding RNAs (lncRNAs) have recently gained focused attention as a new class of regulatory RNA molecules involved in cardiovascular function and associated disease, particularly long intergenic non-coding RNAs (lincRNAs), the largest class of lncRNA described so far. To date, Y chromosome-linked lincRNAs are poorly characterised and the potential link between these RNAs and CAD in men has not been investigated. Aims: The aim of this study is to better understand the potential function of novel Y-linked lincRNAs in men, especially in white blood cells (WBCs) as an effector tissue for CAD. Methods: From the first reference catalogue on human Y chromosomelinked lincRNAs, primers for nine Y-linked lincRNA transcripts (lnc-KDM5D-4:1, lnc- ZFY-1:1, lnc-ZFY-1:3, lnc-ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4, lnc-RBMY1J- 1:1, lnc-RBMY1J-1:2 and lnc-RBMY1J-1:3) were designed using the web-based tool Primer-BLAST from the DNA template sequence available on the LNCipedia, the first database with annotated human Y-linked lncRNAs [in January 2013]. Then, the lincRNA transcripts were analysed by quantitative PCR (qPCR) for differential expression in WBCs 49 from healthy men and in a tissue panel of 20 different normal, human tissues. Results: PCR primers for Y-linked lincRNAs were able to be designed from the DNA template sequence, and qPCR analysis identified distinct tissue-specific expression profiles. The Y chromosome-linked lincRNA transcripts lnc-KDM5D-4:1, lnc-ZFY-1:1, lnc-ZFY-1:3, lnc- ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4 and lnc-RBMY1J-1:3 were found to be expressed in WBCs in healthy men. Conclusion: This is the first study to use gene expression analysis to characterise the expression of Y-linked lincRNAs in humans by providing an expression pattern for the Y-linked lincRNA transcripts, lnc-KDM5D-4:1, lnc-ZFY-1:1, lnc-ZFY-1:3, lnc-ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4, lnc- RBMY1J-1:1, lnc-RBMY1J-1:2 and lnc-RBMY1J-1:3, across 20 human healthy tissues and in blood. Finally, the Y-linked lincRNA transcripts lnc-KDM5D-4:1, lnc-ZFY-1:1, lnc- ZFY-1:3, lnc-ZFY-2:1, lnc-RBMY1B-1:1, lnc-RBMY1B-1:4, and lnc-RBMY1J-1:3 should be further studied, especially in WBCs such as macrophages, as they could be potential candidates for CAD."--Abstract.
Non Coding Rnas In Cardiovascular Diseases
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Author : Junjie Xiao
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Non Coding Rnas In Cardiovascular Diseases written by Junjie Xiao and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Science categories.
This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Non Coding Rnas At The Cross Road Of Cardiometabolic Diseases And Cancer
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Author : Paul Holvoet
language : en
Publisher: Springer Nature
Release Date : 2021-03-26
Non Coding Rnas At The Cross Road Of Cardiometabolic Diseases And Cancer written by Paul Holvoet and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-26 with Medical categories.
This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
Biomarkers In Cardiovascular Disease
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Author : Vijay Nambi
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-11-27
Biomarkers In Cardiovascular Disease written by Vijay Nambi and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-27 with Medical categories.
Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today’s available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Circulating Micrornas
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Author : Takahiro Ochiya
language : en
Publisher: Humana Press
Release Date : 2013-05-30
Circulating Micrornas written by Takahiro Ochiya and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-30 with Medical categories.
microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.
Molecular Biology Of Long Non Coding Rnas
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Author : Ahmad M. Khalil
language : en
Publisher: Springer
Release Date : 2019-06-06
Molecular Biology Of Long Non Coding Rnas written by Ahmad M. Khalil and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-06 with Medical categories.
This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.
Long Non Coding Rnas In Cancer
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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2022-06-25
Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-25 with Medical categories.
This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
The Role Of Epigenetic Modifications In Cancer Progression
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Author : Lei Chang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-17
The Role Of Epigenetic Modifications In Cancer Progression written by Lei Chang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-17 with Science categories.
Non Coding Rnas In Breast Cancer
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Author : Wenwen Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-06
Non Coding Rnas In Breast Cancer written by Wenwen Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Medical categories.
Long Non Coding Rna Biology
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Author : M.R.S. Rao
language : en
Publisher: Springer
Release Date : 2017-08-16
Long Non Coding Rna Biology written by M.R.S. Rao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Medical categories.
This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.