Non Coding Rnas In Breast Cancer
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Non Coding Rnas In Breast Cancer
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Author : Wenwen Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-06
Non Coding Rnas In Breast Cancer written by Wenwen Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Medical categories.
Non Coding Rnas In Breast Cancer Volume Ii
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Author : Wenwen Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-21
Non Coding Rnas In Breast Cancer Volume Ii written by Wenwen Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-21 with Medical categories.
Breast cancer (BC) is the most common malignancy among females worldwide. Breast cancer is a highly heterogeneous malignant tumor which is constitutive of different subtypes according to the status of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2), with diverse clinical performance, biological characteristics and prognosis. Despite early diagnosis and comprehensive treatment, especially the development of endocrine therapy, molecular targeted therapy and the emerging immunotherapies, the mortality of breast cancer has still remained relatively high. Therefore, identification of novel biomarkers for therapeutic targets and efficacy prediction of breast cancer is urgently required. The vast majority of the human genome is made up of non-coding RNA (ncRNA), apart from about 2% protein-coding genes. ncRNAs, including circular RNA (circRNA), circular RNAs (circRNAs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs), have been one of the hot spots in recent years. So far, a large number of ncRNAs have been recognized and found to be dysregulated in various types of cancer including breast cancer. Several ncRNAs have been reported to play critical roles in various biological processes of breast cancer, including cell proliferation, apoptosis, migration, invasion, angiogenesis, differentiation and drug resistance. Moreover, the potential of ncRNAs as diagnostic, prognostic biomarkers, and therapeutic targets has also been explored extensively in breast cancer. Accumulating studies indicating the significance of ncRNAs in the regulation of breast cancer development and drug resistance accelerated the investigation to explore the potential ncRNAs-based therapeutics in breast cancer patients. The main advantage of ncRNA based therapeutics is that it can target multiple coding or non-coding genes that regulate specific or redundant pathways involved in cancer development. However, therapeutics based on ncRNAs encounter some obstacles, such as problems associated with the delivery, potential off-target effects, and safety.
Long Non Coding Rnas In Cancer
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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2021-06-24
Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Medical categories.
This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Breast Cancer Metastasis And Drug Resistance
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Author : Aamir Ahmad
language : en
Publisher: Springer
Release Date : 2020-09-05
Breast Cancer Metastasis And Drug Resistance written by Aamir Ahmad and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-05 with Medical categories.
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Expertsalso discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
Role Of Long Non Coding Rnas In Breast Cancer Progression
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Author : Mahdieh Jadaliha
language : en
Publisher:
Release Date : 2018
Role Of Long Non Coding Rnas In Breast Cancer Progression written by Mahdieh Jadaliha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Clinical Applications Of Noncoding Rnas In Cancer
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Author : Subash Gupta
language : en
Publisher: Academic Press
Release Date : 2022-01-19
Clinical Applications Of Noncoding Rnas In Cancer written by Subash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-19 with Science categories.
Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. - Presents a beginning chapter summary to help readers understand the content thoroughly - Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy - Discusses one cancer type per chapter making the content easy to reference
Non Coding Rna As Prognostic And Diagnostic Biomarkers In Thoracic Oncology
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Author : Desi Shang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09
Non Coding Rna As Prognostic And Diagnostic Biomarkers In Thoracic Oncology written by Desi Shang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Medical categories.
Cancer And Noncoding Rnas
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Author : Jayprokas Chakrabarti
language : en
Publisher: Academic Press
Release Date : 2017-10-13
Cancer And Noncoding Rnas written by Jayprokas Chakrabarti and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-13 with Medical categories.
Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. - Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics - Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis - Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies - Features contributions by leading experts in the field
The Role Of Ncrnas Non Coding Rnas In Regulating Tumor Immune Microenvironment
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Author : Yanyan Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-14
The Role Of Ncrnas Non Coding Rnas In Regulating Tumor Immune Microenvironment written by Yanyan Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-14 with Science categories.
Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease
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Author : Amanda Salviano-Silva
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-11
Genetic And Epigenetic Aspects Of Non Coding Rnas In Physiology And Disease written by Amanda Salviano-Silva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-11 with Science categories.