Non Invasive Optical Detection Of Epithelial Cancer Using Oblique Incidence Diffuse Reflectance Spectroscopy
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Non Invasive Optical Detection Of Epithelial Cancer Using Oblique Incidence Diffuse Reflectance Spectroscopy
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Author : Alejandro Garcia-Uribe
language : en
Publisher:
Release Date : 2010
Non Invasive Optical Detection Of Epithelial Cancer Using Oblique Incidence Diffuse Reflectance Spectroscopy written by Alejandro Garcia-Uribe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
This dissertation describes the design, fabrication and testing of an oblique incidence diffuse reflectance spectrometry (OIDRS) system for in-vivo and noninvasive detection of epithelial cancer. Two probes were fabricated using micromachining technology, which plays a significant role in the probe development by enabling device miniaturization, low-cost fabrication and precise assembly. The fist probe was developed and clinically tested for skin cancer detection. This probe consists of three source fibers, two linear array of collection fibers and four micromachined positioning devices for accurate alignment of the fibers. The spatially resolved diffuse reflectance spectra from 167 pigmented and 78 non-pigmented skin abnormalities were measured and used to design a set of classifiers to separate them into benign or malignant ones. These classifiers perform with an overall classification rate of 91%. The absorption and reduced scattering coefficient spectra were estimated to link the anatomic and physiologic properties of the lesions with the optical diagnosis. The melanoma cases presented larger average absorption and reduced scattering spectra than the dysplastic and benign ones. A second probe was designed to demonstrate the feasibility of a miniaturized?side viewing? optical sensor probe for OIDRS. The sensor probe consists of a lithographically patterned polymer waveguides chip and two micromachined positioning substrates. This miniaturize probe was used to measure twenty ex-vivo esophageal samples. Two statistical classifiers were designed to separate the esophageal cases. The first one distinguishes benign and low dysplastic from high dysplastic and cancerous lesions. The second classifier separates benign lesions from low dysplastic ones. Both classifiers generated a classification rate of 100%.
Optical Imaging For Biomedical And Clinical Applications
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Author : Ahmad Fadzil Mohamad Hani
language : en
Publisher: CRC Press
Release Date : 2017-10-30
Optical Imaging For Biomedical And Clinical Applications written by Ahmad Fadzil Mohamad Hani and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-30 with Medical categories.
Optical imaging is a rapidly emerging imaging technique that has been successfjully translated into biomedical applications ranging from clinical diagnosis to molecular biology. This book includes an introductory section to explore various optical imaging devices and their functionality and roles for biomedical applications such as dermatology and ophthalmology. Recent developments as exemplified with the authors research are explored in detail. In depth discussion of other disease conditions and their diagnosis with optical imaging techniques are also covered.
Handbook Of Biomedical Optics
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Author : David A. Boas
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Handbook Of Biomedical Optics written by David A. Boas and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamental
Biomedical Optics In Otorhinolaryngology
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Author : Brian J.-F. Wong
language : en
Publisher: Springer
Release Date : 2016-08-22
Biomedical Optics In Otorhinolaryngology written by Brian J.-F. Wong and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-22 with Medical categories.
Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past 15 years, optical diagnostics and head and neck PDT (photodynamic therapy) are usually entirely overlooked. This book contains a basic introduction into the physics of light and its propagation, lasers and low-coherent light sources, and photon-tissue interaction in relation to therapeutic and diagnostic use. The principles of various imaging techniques are also discussed ( i.e. optical coherence tomography in its variations), as well as the principles and practice of lasers for surgical use on the therapeutic side.
Intelligent Energy Field Manufacturing
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Author : Wenwu Zhang
language : en
Publisher: CRC Press
Release Date : 2018-10-03
Intelligent Energy Field Manufacturing written by Wenwu Zhang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-03 with Technology & Engineering categories.
Edited by prominent researchers and with contributions from experts in their individual areas, Intelligent Energy Field Manufacturing: Interdisciplinary Process Innovations explores a new philosophy of engineering. An in-depth introduction to Intelligent Energy Field Manufacturing (EFM), this book explores a fresh engineering methodology that not only integrates but goes beyond methodologies such as Design for Six Sigma, Lean Manufacturing, Concurrent Engineering, TRIZ, green and sustainable manufacturing, and more. This book gives a systematic introduction to classic non-mechanical manufacturing processes as well as offering big pictures of some technical frontiers in modern engineering. The book suggests that any manufacturing process is actually a process of injecting human intelligence into the interaction between material and the various energy fields in order to transfer the material into desired configurations. It discusses technological innovation, dynamic M-PIE flows, the generalities of energy fields, logic functional materials and intelligence, the open scheme of intelligent EFM implementation, and the principles of intelligent EFM. The book takes a highly interdisciplinary approach that includes research frontiers such as micro/nano fabrication, high strain rate processes, laser shock forming, materials science and engineering, bioengineering, etc., in addition to a detailed treatment of the so called "non-traditional" manufacturing processes, which covers waterjet machining, laser material processing, ultrasonic material processing, EDM/ECM, etc. Filled with illustrative pictures, figures, and tables that make technical materials more absorbable, the book cuts across multiple engineering disciplines. The majority of books in this area report the facts of proven knowledge, while the behind-the-scenes thinking is usually neglected. This book examines the big picture of manufacturing in depth before diving into the deta
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Diffuse Reflectance Endoscopic Imaging For Bladder Early Stage Cancer And Pre Cancer Diagnosis
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Author : Nina Kalyagina
language : en
Publisher:
Release Date : 2012
Diffuse Reflectance Endoscopic Imaging For Bladder Early Stage Cancer And Pre Cancer Diagnosis written by Nina Kalyagina and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The present thesis aimed to evaluate the performance of non-invasive optical method for bladder pre- and early- cancer detection by means of diffuse-reflected laser light analysis. The analysis of light distribution at the surface of multi-layered bladder phantoms with different scattering and absorption properties showed that the changes in the optical properties lead to increase or decrease of the diffuse-reflected light spot area, detectable by a video camera. It was also determined, that the presented method is capable of detection of the photosensitizer accumulation, and can be applied for both (diffuse-reflected laser and fluorescence) studies simultaneously. The calculations for spherical and ?coated?-spherical tissue scatterers, based on the electromagnetic wave theory, allowed for obtaining optical parameters of three-layered biological phantoms and of bladder tissues at different states. These parameters served as inputs for Monte Carlo simulations, which provided us with matrices of diffuse-reflected light distributions. The study showed that the measurements of non-polarized back-scattered laser light can provide useful information on the tissue state.
Encyclopedia Of Spectroscopy And Spectrometry
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-09-22
Encyclopedia Of Spectroscopy And Spectrometry written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-22 with Science categories.
This third edition of the Encyclopedia of Spectroscopy and Spectrometry, Three Volume Set provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas
Diagn Stico Por Imagen En Dermatolog A
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Author : Michael R. Hamblin
language : en
Publisher: Elsevier
Release Date : 2017-06-24
Diagn Stico Por Imagen En Dermatolog A written by Michael R. Hamblin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-24 with categories.
Diagnóstico por imagen en dermatología cubre las más importantes técnicas de imagen diagnóstica empleadas en la especialidad, tanto desde un punto de vista clínico como por lo que respecta a las implicaciones de su uso en investigación. Se abordan no solo las aplicaciones actuales sino también las tendencias futuras de este campo en constante y rápida evolución, proporcionando a clínicos e investigadores una comprensión clara y precisa de las ventajas y retos del empleo actual de las diversas técnicas de imagen en dermatología, incluyendo sus efectos a nivel celular y molecular. Proporciona información sobre un extenso repertorio de técnicas, desde las más convencionales hasta las más novedosas, desde un punto de vista clínico y de investigación. Aborda el diagnóstico por imagen de enfermedades como la queratosis actínica, el melanoma cutáneo, el carcinoma de células de Merkel, la hidradenitis supurativa, etc. Es de fácil consulta gracias a la estructura clara y sistemática de la información, ilustrada con numerosas fotografías e imágenes en color. Se dirige a dermatólogos clínicos y a investigadores en las áreas de dermatología, radiología, farmacéutica, biología molecular, diagnóstico y tratamiento del cáncer, y biotecnología. Obra que contiene toda la información esencial para el empleo de las técnicas de imagen en el diagnósticos, tratamiento, monitorización y an ́ ́alisis de las enfermedades cutáneas, de la mano de un prestigiosos equipo de expertos. Cubre las más importantes técnicas de imagen diagnóstica empleadas en la especialidad, tanto des un punto de vista clínico como por lo que respecta a las implicaciones de su uso en investigación. Obra de fácil consulta gracias a la estructura clara y sistemática de la información, profusamente ilustrada. Aborda el diagnóstico por imagen de enfermedades como la queratosis actínica, el melanoma cutáneo, el carcinoma de células de Merkel, la hisdradenitis supurativa, etc. Se dirige a dermatólogos clínicos y a investigadores en las áreas de dermatología, radiología, farmacéutica, biología molecular, diagnóstico y tratamiento del cáncer y biotecnología.
Sensitivity Of Diffuse Reflectance Spectroscopy To Dose And Depth Dependent Changes In Tumor Oxygenation After Radiation Therapy
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Author : Daria Semeniak
language : en
Publisher:
Release Date : 2017
Sensitivity Of Diffuse Reflectance Spectroscopy To Dose And Depth Dependent Changes In Tumor Oxygenation After Radiation Therapy written by Daria Semeniak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Cancer categories.
Along with chemotherapy, immunotherapy, and surgery, radiotherapy is one of the most common treatments used against cancer. Around 50% of all cancer patients undergo radiation therapy. While for some patients radiotherapy works efficiently and lead to a complete cancer disappearance, for others treatment outcome may be less favorable due to radioresistance processes happening within a tumor on the molecular level. Radioresistance remains a big challenge for modern oncology. The ability to identify radioresistance at the early stage of radiotherapy would help physicians to improve therapy efficiency. At the current moment, despite the rapid progress in cancer understanding and diagnostic modalities, there is no established technique that would enable early identification of tumor radioresistance. Tumor oxygenation plays a crucial role for radiotherapy efficiency. We hypothesize that diffuse reflectance spectroscopy (DRS) enabling repeated non-invasive measurements of tumor vascular oxygen saturation can provide surrogate measures of tumor oxygenation to predict tumor response to therapy. The goal of this study is to determine the sensitivity of diffuse reflectance spectroscopy to changes in tumor oxygenation after single-dose radiation therapy in a preclinical tumor xenograft model. We established three specific aims addressing the ability of DRS to provide accurate measures of tumor properties. The first aim is to determine the effect skin thickness on the extraction of optical parameters using one-layer Lookup Table (LUT) model. The second aim is to determine depth- and dose-dependent changes in DRS-measured vascular oxygenation during radiotherapy. The third aim is to determine the association between DRS-measured vascular oxygenation and immunohistochemically assessed intracellular hypoxia. Our results demonstrate a significant impact of skin thickness on the extraction of optical parameters for short source-detector separations caused by the one-layer assumption of the LUT model. We also detected LUT model failure to identify the absence of melanin when skin is mechanically removed. These findings suggest that existing LUT model needs to be modified to account for the effect of the skin layer. Measurements with different source-detector separations revealed higher concentration of hemoglobin in superficial layer of tumors and blood supply disruption after exposure to 8 Gy of radiation.