Non Natural Nucleic Acids

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Non Natural Nucleic Acids

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Author : Nathaniel Shank
language : en
Publisher:
Release Date : 2019

Non Natural Nucleic Acids written by Nathaniel Shank and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Genetics categories.

This volume provides relevant synthetic strategies, incorporation, and applications of non-natural nucleic acids. Chapters detail monomer synthesis, oligomer synthesis/construction, and applications allowing researchers to explore and determine which methodology or methodologies are relevant to their needs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Non-Natural Nucleic Acids: Methods and Protocols aims to serve as a guide for researchers exploring their own inquiries and to provide a springboard for new endeavors.

Probing Ribonuclease A Catalysis Using Non Natural Nucleic Acids

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Author : Bradley Roger Kelemen
language : en
Publisher:
Release Date : 1999

Probing Ribonuclease A Catalysis Using Non Natural Nucleic Acids written by Bradley Roger Kelemen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.

Chemistry And Biology Of Artificial Nucleic Acids

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Author : Martin Egli
language : en
Publisher: Wiley-VCH
Release Date : 2012-04-16

Chemistry And Biology Of Artificial Nucleic Acids written by Martin Egli and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-16 with Science categories.

This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. Covering a tremendous amount of literature on the chemistry, biology, and structure of artificial nucleic acids, it will constitute an invaluable source of information for the specialist and for young researchers interested in starting a career in this fascinating field of research alike. This book combines the contributions of many of the major players in this research field, and covers the synthesis of sugar-, base- and backbone-modified nucleic acids, their structural characteristics studied by X-ray crystallography, and NMR in solution as well as their chemical and biological properties.

Enzymatic And Chemical Synthesis Of Nucleic Acid Derivatives

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Author : Jesús Fernández Lucas
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-29

Enzymatic And Chemical Synthesis Of Nucleic Acid Derivatives written by Jesús Fernández Lucas and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Science categories.

A review of innovative tools for creative nucleic acid chemists that open the door to novel probes and therapeutic agents Nucleic acids continue to gain importance as novel diagnostic and therapeutic agents. With contributions from noted scientists and scholars, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practical reference that includes a wide range of approaches for the synthesis of designer nucleic acids and their derivatives. The book covers enzymatic (including chemo-enzymatic) methods, with a focus on the synthesis and incorporation of modified nucleosides. The authors also offer a review of innovative approaches for the non-enzymatic chemical synthesis of nucleic acids and their analogs and derivatives, highlighting especially challenging species. The book offers a concise review of the methods that prepare novel and heavily modified polynucleotides in sufficient amount and purity for most clinical and research applications. This important book: -Presents a timely and topical guide to the synthesis of designer nucleic acids and their derivatives -Addresses the growing market for nucleotide-derived pharmaceuticals used as anti-infectives and chemotherapeutic agents, as well as fungicides and other agrochemicals. -Covers novel methods and the most recent trends in the field -Contains contributions from an international panel of noted scientistics Written for biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practice-oriented guide that reviews innovative methods for the enzymatic as well as non-enzymatic synthesis of nucleic acid species.

Synthesis And Survey Of Non Natural Bases In Nucleic Acids

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Author : Dominic Francis Qualley
language : en
Publisher:
Release Date : 2007

Synthesis And Survey Of Non Natural Bases In Nucleic Acids written by Dominic Francis Qualley and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Chemistry And Biology Of Non Canonical Nucleic Acids

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Author : Naoki Sugimoto
language : en
Publisher: John Wiley & Sons
Release Date : 2021-03-16

Chemistry And Biology Of Non Canonical Nucleic Acids written by Naoki Sugimoto and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-16 with Science categories.

Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

Synthesis Of Non Natural Base Pairs

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Author : Helena Stubbe Buchanan
language : en
Publisher:
Release Date : 2021

Synthesis Of Non Natural Base Pairs written by Helena Stubbe Buchanan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.

Computational Studies Of Natural And Nonnatural Nucleic Acids

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Author : Andrew T. Johnson
language : en
Publisher:
Release Date : 2011

Computational Studies Of Natural And Nonnatural Nucleic Acids written by Andrew T. Johnson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Modified Nucleic Acids

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Author : Kazuhiko Nakatani
language : en
Publisher: Springer
Release Date : 2016-04-04

Modified Nucleic Acids written by Kazuhiko Nakatani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-04 with Science categories.

This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Intercalator Mediated Assembly Of Nucleic Acids

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Author : Eric D. Horowitz
language : en
Publisher:
Release Date : 2009

Intercalator Mediated Assembly Of Nucleic Acids written by Eric D. Horowitz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Life categories.

In this thesis, I explore the role of the sugar-phosphate backbone in dictating the structure and thermodynamics of nucleic acid intercalation by using 20́ø,50́ø-linked RNA intercalation as a model system of non-natural nucleic acid intercalation. The solution structure of an intercalator-bound 20́ø,50́ø RNA duplex reveals structural and thermodynamic aspects of intercalation that provide insight into the origin of the nearest-neighbor exclusion principle, a principle that is uniformly obeyed upon the intercalation of natural (i.e. 30́ø,50́ø-linked) RNA and DNA. I also demonstrate the ability of intercalator-mediated assembly to circumvent the strand-cyclization problem, a problem that otherwise greatly limits the polymerization of short oligonucleotides into long polymers. Together, the data presented in this thesis illustrate the important role that the nucleic acid backbone plays in governing the thermodynamics of intercalation, and provide support for the proposed role of intercalator-mediated assembly in the prebiotic formation of nucleic acids.