Novel Antipsychotics Within And Beyond Clinical Trials The Treatment Of Overlapping Psychiatric Disorders With D3 D2 Partial Agonists
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Novel Antipsychotics Within And Beyond Clinical Trials The Treatment Of Overlapping Psychiatric Disorders With D3 D2 Partial Agonists
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Author : György Németh
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-10
Novel Antipsychotics Within And Beyond Clinical Trials The Treatment Of Overlapping Psychiatric Disorders With D3 D2 Partial Agonists written by György Németh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-10 with Medical categories.
Polypharmacology
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Author : Jens-Uwe Peters
language : en
Publisher: John Wiley & Sons
Release Date : 2025-01-09
Polypharmacology written by Jens-Uwe Peters and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-09 with Medical categories.
Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examples Polypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer. The book provides practical guidelines and advice to help readers design drugs that have multiple targets while minimizing unwanted off-target effects, discusses important disease areas like viral infection, diabetes, and obesity that have advanced significantly in the last decade, and guides researchers in neighboring areas to polypharmacology. The book is divided into four parts. Part A covers the link between off-targets and adverse drug reactions, how to screen for off-target activity, and how to recognize and optimize compounds with a potential for off-target activity. Part B discusses disease areas which benefit from polypharmacological approaches. Part C highlights important approaches, such as compound design, data mining with web-based tools, and multi-target peptides. Part D provides case study coverage on topics like CDK4/6 inhibitors for cancer treatment, the potential of multi-target ligands for COVID, and protein degraders and PROTACs. Sample topics discussed in Polypharmacology include: Molecular properties and structural motifs in pharmacological promiscuity, covering lipophilicity, molecular weight, and other parameters Kinase liabilities in early drug discovery, covering core kinases driving the cell division cycle and consequences of interference, and cell cycle checkpoints controlling cell division Treatment of major depressive disorder, covering tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin and norepinephrine reuptake inhibitors Trends in the field, such as novel antipsychotics, standardization of screening tools, and the SmartCube System®, as well as lessons from history Delivering the latest research developments in the field, Polypharmacology is an essential reference on the subject for medicinal chemists, pharmacologists, biochemists, computational chemists, and biologists, as well as pharmaceutical professionals involved in drug discovery programs.
Novel Antischizophrenia Treatments
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Author : Mark A. Geyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-08-31
Novel Antischizophrenia Treatments written by Mark A. Geyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with Medical categories.
This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. The volume will concentrate on reviewing the ongoing research attempting to identify novel treatments for the cognitive deficits and negative symptoms of schizophrenia, which are not treated adequately by current antipsychotic medications.
Practical Psychopharmacology
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Author : Joseph F. Goldberg
language : en
Publisher: Cambridge University Press
Release Date : 2021-04-29
Practical Psychopharmacology written by Joseph F. Goldberg and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-29 with Medical categories.
A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.
Gabbard S Treatments Of Psychiatric Disorders Fifth Edition
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Author : Glen O. Gabbard, M.D.
language : en
Publisher: American Psychiatric Pub
Release Date : 2014-05-05
Gabbard S Treatments Of Psychiatric Disorders Fifth Edition written by Glen O. Gabbard, M.D. and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-05 with Medical categories.
The definitive treatment textbook in psychiatry, this fifth edition of Gabbard's Treatments of Psychiatric Disorders has been thoroughly restructured to reflect the new DSM-5® categories, preserving its value as a state-of-the-art resource and increasing its utility in the field. The editors have produced a volume that is both comprehensive and concise, meeting the needs of clinicians who prefer a single, user-friendly volume. In the service of brevity, the book focuses on treatment over diagnostic considerations, and addresses both empirically-validated treatments and accumulated clinical wisdom where research is lacking. Noteworthy features include the following: *Content is organized according to DSM-5® categories to make for rapid retrieval of relevant treatment information for the busy clinician.*Outcome studies and expert opinion are presented in an accessible way to help the clinician know what treatment to use for which disorder, and how to tailor the treatment to the patient.*Content is restricted to the major psychiatric conditions seen in clinical practice while leaving out less common conditions and those that have limited outcome research related to the disorder, resulting in a more streamlined and affordable text.*Chapters are meticulously referenced and include dozens of tables, figures, and other illustrative features that enhance comprehension and recall. An authoritative resource for psychiatrists, psychologists, and psychiatric nurses, and an outstanding reference for students in the mental health professions, Gabbard's Treatments of Psychiatric Disorders, Fifth Edition, will prove indispensable to clinicians seeking to provide excellent care while transitioning to a DSM-5® world.
Medication Induced Movement Disorders
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Author : Joseph H. Friedman
language : en
Publisher: Cambridge University Press
Release Date : 2015-06-17
Medication Induced Movement Disorders written by Joseph H. Friedman and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-17 with Medical categories.
Medications that may produce movement disorders are widely used. The resulting disorders are often highly disconcerting for the patient and their relatives, especially when the connection between medication and disorder is not recognized. However, ascribing an adverse drug effect to medication exposure is often difficult, especially when the side effect is rare. Covering various drugs - including the major classes of medications working primarily on the brain, specifically antipsychotics and antidepressants – this all-encompassing review of medication-induced movement disorders aids early recognition and improved treatment. The problem of what to do when the offending medication cannot be reduced is also reviewed. It discusses the best options for evaluation and treatment, including medical imaging and deep brain stimulation, and guides the clinician in managing the disorder, making this a vital reference for medical specialists and consultants in neurology and neuropharmacology and any clinician seeing patients on medications crossing the blood-brain barrier.
Early Intervention In Psychotic Disorders
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Author : Tandy Miller
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-05-31
Early Intervention In Psychotic Disorders written by Tandy Miller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-31 with Medical categories.
Proceedings of the NATO Advanced Research Workshop on Early Intervention in Psychiatric Disorders, Prague, Czech Republic, October 22-27, 1998
Mastering Psychiatry A Core Textbook For Undergraduates
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Author : Melvyn WB Zhang
language : en
Publisher: Lulu.com
Release Date : 2013-11-07
Mastering Psychiatry A Core Textbook For Undergraduates written by Melvyn WB Zhang and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-07 with Science categories.
This comprehensive textbook covers common psychiatric conditions encountered in adults, children, adolescents and old people. This book provides core information you need for undergraduate examination and future clinical practices. A smartphone application is now available for free download on both the Apple ITunes store as well as on the Android Play Market. https: //itunes.apple.com/us/app/mastering-psychiatry-core/id720709591?mt=8 https: //play.google.com/store/apps/details?id=com.tiseno.psychiatry Or simply search "Mastering Psychiatry" and you will be able to get a free preview copy of the entire book with all the multimedia features.
First Episode Psychosis
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Author : Katherine J. Aitchison
language : en
Publisher: CRC Press
Release Date : 1999-02-17
First Episode Psychosis written by Katherine J. Aitchison and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-02-17 with Medical categories.
The new edition of this popular handbook has been thoroughly updated to include the latest data concerning treatment of first-episode patients. Drawing from their experience, the authors discuss the presentation and assessment of the first psychotic episode and review the appropriate use of antipsychotic agents and psychosocial approaches in effective management.
Obsessive Compulsive Symptoms In Schizophrenia
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Author : Lieuwe De Haan
language : en
Publisher: Springer
Release Date : 2015-02-26
Obsessive Compulsive Symptoms In Schizophrenia written by Lieuwe De Haan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-26 with Medical categories.
This book summarizes scientific advances in our understanding of the interrelationship between obsessive-compulsive symptoms and schizophrenia and reflects on the implications for future research directions. In addition, guidelines are provided on practical assessment, diagnosis and treatment interventions, covering both pharmacotherapy and psychotherapy. The book acknowledges the need for a perspective that recognizes heterogeneous subgroups and diverse neurobiological explanations; accordingly, multidimensional research-based conceptual frameworks are provided that incorporate recent epidemiological, neurocognitive, neurogenetic and pharmacodynamic findings. Obsessive-Compulsive Symptoms in Schizophrenia has been written by an international team of experts who offer insights gained through their extensive experience. It will be an invaluable guide to this frequent and clinically important comorbidity and will be particularly useful for mental health practitioners.