Novel Aspects On Motor Neuron Disease
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Novel Aspects On Motor Neuron Disease
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Author : Humberto Foyaca Sibat
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-05-20
Novel Aspects On Motor Neuron Disease written by Humberto Foyaca Sibat and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-20 with Medical categories.
Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.
Clinical And Molecular Aspects Of Motor Neuron Disease
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Author : Johnathan Cooper-Knock
language : en
Publisher: Morgan & Claypool
Release Date : 2013-09-01
Clinical And Molecular Aspects Of Motor Neuron Disease written by Johnathan Cooper-Knock and has been published by Morgan & Claypool this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-01 with HEALTH & FITNESS categories.
In this e-book, motor neuron disease (MND) shall refer to amyotrophic lateral sclerosis (ALS), the most common neurodegenerative disorder affecting both the upper and lower motor neurons. With the discovery of C9ORF72 expansions in approximately 10% of all MND cases, in certain populations, we stand at the brink of a new era of MND research and hopefully treatment facilitated by the ability to associate a relatively large group of patients with a similar disease mechanism. This review will summarise both current clinical management of MND and our present understanding of the molecular pathogenesis of MND. Study of C9ORF72-MND has the potential to rapidly advance both of these aspects in the coming years. In the first section, we will discuss the clinical features of MND and describe how patients with this devastating condition present, are investigated, and managed in the 21st century. Although, currently, management is limited by an incomplete understanding of disease pathophysiology, there is much which can be done to assist and support patients with MND. In the following sections, we will discuss molecular mechanisms implicated in MND, highlighting observations which unify different theories. Particular attention will be given to placing proposed mechanisms within the clinical course of MND. Furthermore, novel therapeutic targets will be discussed. Table of Contents: Clinical Aspects of MND / Molecular Aspects of MND / References / Author Biographies / Titles of Related Interest / Series of Related Interest
Motor Neuron Disease In Adults
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Author : M. B. Bromberg
language : en
Publisher:
Release Date : 2014
Motor Neuron Disease In Adults written by M. B. Bromberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.
Motor Neuron Disease
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Author : P.N. Leigh
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Motor Neuron Disease written by P.N. Leigh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Here is the first book to provide a comprehensive overview of the clinical, pathological, and research aspects of motor neuron disease (MND). The text contains all essential features of the anatomy, physiology, pharmacology and toxicology of the motor system, a full description of MND and its variants, as well as historical developments and a review of the current concepts and controversies. This book comes at a time of increasing interest in neurodegenerative disorders and MND in particular. It will prove a key reference book with an integrated overview of the field, and will be indispensable to practicing neurologists, researchers, and all those with an interest in MND.
Motor Neuron Disease
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Author :
language : en
Publisher:
Release Date : 1994
Motor Neuron Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Motor Neuron Disease In Adults
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Author : Mark B. Bromberg
language : en
Publisher: Contemporary Neurology
Release Date : 2014-10-28
Motor Neuron Disease In Adults written by Mark B. Bromberg and has been published by Contemporary Neurology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-28 with Medical categories.
'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.
Motor Neuron Disease Research Progress
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Author : Raffaele L. Mancini
language : en
Publisher: Nova Publishers
Release Date : 2008
Motor Neuron Disease Research Progress written by Raffaele L. Mancini and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Amyotrophic lateral sclerosis categories.
The motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neurons control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region. Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech. This new book presents the latest research from around the globe.
Molecular And Cellular Therapies For Motor Neuron Diseases
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Author : Nicholas M Boulis
language : en
Publisher: Academic Press
Release Date : 2017-01-18
Molecular And Cellular Therapies For Motor Neuron Diseases written by Nicholas M Boulis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-18 with Psychology categories.
Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy
Amyotrophic Lateral Sclerosis
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Author : V. Cosi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Amyotrophic Lateral Sclerosis written by V. Cosi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
An International Conference on "Therapeutic. Psychological and Research Aspects of Amyotrophic Lateral Sclerosis" was held in Varese. Italy from the 27th to the 31st March 1985. Health care professionals. scientists. patients and their families from twenty countries around the world participated in this meeting. The objectives of the Varese conference were the following: a. To provide a forum for the proponents of the various paths of research into ALS. b. To correlate the useful therapies employed regionally. for the purpose of developing a common guide for patients, families, and supporting professionals. c. To encourage self-examination by the health care professionals into the psychological barriers imposed by a diagnosis of terminal illness for which there is no known cause or cure. Not surprisingly, there were no announcements of "breakthroughs" or "miracle cures", which are nonetheless hoped for in the confrontation of a disease such as ALS. It is fair to say, however, that Varese provided the context for a thorough review of what is known about ALS and we hope that the papers will renew some of the enthusiasm which has characterized this conference. The book contains six sections: Basic Research Aspects, Diagnostic Tools, Clinical Management, Therapeutic Trials, Psychological Aspects and the Epidemiology of ALS. Certain aspects, such as pathological studies and animal models, have not been covered; these subjects were partially treated during the informal sessions. Nevertheless, the large number of papers bears evidence to the growing interest in ALS and to the success of the Varese meeting.
Neuromuscular Function And Disease
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Author :
language : en
Publisher:
Release Date : 2002
Neuromuscular Function And Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Efferent pathways categories.