Molecular And Cellular Therapies For Motor Neuron Diseases
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Molecular And Cellular Therapies For Motor Neuron Diseases
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Author : Nicholas M Boulis
language : en
Publisher: Academic Press
Release Date : 2017-01-18
Molecular And Cellular Therapies For Motor Neuron Diseases written by Nicholas M Boulis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-18 with Psychology categories.
Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy
Novel Aspects On Motor Neuron Disease
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Author : Humberto Foyaca Sibat
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-05-20
Novel Aspects On Motor Neuron Disease written by Humberto Foyaca Sibat and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-20 with Medical categories.
Dedicated to our readers, we include novel information (not reported in IntechOpen’s books before) about new contributions of aberrant astrocytes to MND damage and death in the SOD1G93A rat experimental model of ALS; novel genetic studies on ALS; an update of the structural and functional consequences of the spinal muscular atrophy-linked mutations of the survival motor neuron protein; stem cell therapy for MND; and the novel treatment for SMA and ALS in the introductory chapter. This book contains selected peer-reviewed chapters written by international researchers. In this publication, the readers will find a compilation of state-of-the-art reviews about etiology, therapies, investigations, the molecular basis of disease progression and clinical manifestations, and the genetic familial ALS, as well as novel therapeutic modalities. We look forward with confidence and pride to the remarkable role that this book will play for a new vision and mission.
Motor Neuron Disease
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Author : Kevin Talbot
language : en
Publisher: Oxford University Press
Release Date : 2010
Motor Neuron Disease written by Kevin Talbot and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Written and designed to provide comprehensive, easily accessible advice for all healthcare professionals involved in the care of patients with this challenging condition, this book addresses the entire care pathway from presentation to diagnosis to symptom management and end of life issues.
Clinical And Molecular Aspects Of Motor Neuron Disease
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Author : Johnathan Cooper-Knock
language : en
Publisher: Biota Publishing
Release Date : 2013-09-01
Clinical And Molecular Aspects Of Motor Neuron Disease written by Johnathan Cooper-Knock and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-01 with Science categories.
In this e-book, motor neuron disease (MND) shall refer to amyotrophic lateral sclerosis (ALS), the most common neurodegenerative disorder affecting both the upper and lower motor neurons. With the discovery of C9ORF72 expansions in approximately 10% of all MND cases, in certain populations, we stand at the brink of a new era of MND research and hopefully treatment facilitated by the ability to associate a relatively large group of patients with a similar disease mechanism. This review will summarise both current clinical management of MND and our present understanding of the molecular pathogenesis of MND. Study of C9ORF72-MND has the potential to rapidly advance both of these aspects in the coming years.
Cell Press Reviews Stem Cells To Model And Treat Disease
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Author : Cell Press
language : en
Publisher: Elsevier
Release Date : 2013-12-03
Cell Press Reviews Stem Cells To Model And Treat Disease written by Cell Press and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-03 with Science categories.
Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including: Safety and efficacy of stem cell treatments Stem-cell-based organ regeneration Integrating stem cells into personalized drug discovery Using pluripotent stem cells for treating neurological disease Engineering hematopoietic stem cells for innovative therapies Contributions come from leading voices in the field, including: - Shinya Yamanaka, Recipient of the 2012 Nobel Prize for Physiology or Medicine, Recipient of the 2012 Millennium Technology Prize, Professor and Director of the Center for iPS Cell Research and Application at Kyoto University, Senior Investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology and Professor at the University of California, San Francisco - George Q. Daley, Samuel E. Lux IV Professor of Hematology/Oncology at Harvard Medical School and Director for the Stem Cell Transplantation Program at Boston Children’s Hospital - Irving Weissman, Member of National Academy of Sciences, Virgina & D.K Ludwig Professor for Clinical Investigation in Cancer Research, and Director for Institute of Stem Cell Biology and Regenerative Medicine at Stanford University of Medicine Cell Press Reviews: Stem Cells to Model and Treat Disease is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals. Provides timely overviews on a wide range of stem cell applications Offers insight from experts on the key opportunities and challenges facing the field Features reviews on genetic, cellular, and molecular aspects of stem-cell-based applications Includes articles originally published in Cell, Cell Stem Cell, Neuron, Trends in Molecular Medicine, and Trends in Biotechnology
Motor Neuron Disease In Adults
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Author : Mark B. Bromberg
language : en
Publisher: Contemporary Neurology
Release Date : 2014-10-28
Motor Neuron Disease In Adults written by Mark B. Bromberg and has been published by Contemporary Neurology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-28 with Medical categories.
'Motor Neuron Disease in Adults' reviews new information from 1998 as it applies to all aspects of motor neuron disease. Articles included use evidence-based methods to ensure that the new information is solid and advances the topic. The book can be used by anyone who provides any type of care to ALS patients.
Neurodegenerative Diseases
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Author : Uday Kishore
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-05-15
Neurodegenerative Diseases written by Uday Kishore and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-15 with Medical categories.
This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
Gene And Cell Therapy
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Author : Nancy Smyth Templeton
language : en
Publisher: CRC Press
Release Date : 2008-10-06
Gene And Cell Therapy written by Nancy Smyth Templeton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-06 with Science categories.
Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies. The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.
The Future Of Pharmaceuticals
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Author : Sarfaraz K. Niazi
language : en
Publisher: CRC Press
Release Date : 2022-03-01
The Future Of Pharmaceuticals written by Sarfaraz K. Niazi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-01 with Medical categories.
Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.
Understanding Neuromuscular Health And Disease
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Author : William Duddy
language : en
Publisher: Mdpi AG
Release Date : 2021-11-08
Understanding Neuromuscular Health And Disease written by William Duddy and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-08 with Science categories.
This compilation focuses on recent advances in the molecular and cellular understanding of neuromuscular biology, and the treatment of neuromuscular disease. These advances are at the forefront of modern molecular methodologies, often integrating across wet-lab cell and tissue models, dry-lab computational approaches, and clinical studies. The continuing development and application of multiomics methods offer particular challenges and opportunities in the field, not least in the potential for personalized medicine.