Novel Delivery Sys For Oral Vaccines
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Novel Delivery Sys For Oral Vaccines
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Author : Derek T. O'Hagan
language : en
Publisher: Springer
Release Date : 1994-04-15
Novel Delivery Sys For Oral Vaccines written by Derek T. O'Hagan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-04-15 with Medical categories.
This one-of-a-kind book represents a timely and detailed assessment of the wide range of alternative "antigen carriers" that are currently being investigated as prospective delivery systems for the development of new and improved oral vaccines. Oral delivery remains the "ideal" approach to vaccination, both for economic reasons and for reasons of patient acceptability. However, the oral route of immunization remains under exploited, clinically, mainly because oral vaccines have traditionally been poorly immunogenic. Nevertheless, recent developments in the formulation of nonliving antigen carrier systems and in the development of live nonpathogenic carrier systems have given rise to real optimism that new oral vaccines will soon be developed. This book looks at these new developments in antigen delivery systems. Each alternative carrier system is assessed, including both its potential advantages and limitations. The book details how these antigen delivery systems might contribute to the development of new and improved oral vaccines for human use.
Nanoparticulate Vaccine Delivery Systems
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Author : Martin J. D'Souza
language : en
Publisher: CRC Press
Release Date : 2015-06-01
Nanoparticulate Vaccine Delivery Systems written by Martin J. D'Souza and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Medical categories.
Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formula
Vaccine Adjuvants And Delivery Systems
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Author : Manmohan Singh
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-03
Vaccine Adjuvants And Delivery Systems written by Manmohan Singh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-03 with Science categories.
The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.
Subunit Vaccine Delivery
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Author : Camilla Foged
language : en
Publisher: Springer
Release Date : 2014-11-22
Subunit Vaccine Delivery written by Camilla Foged and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-22 with Medical categories.
This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.
Delivery Of Vaccines And Therapeutics To Treat Infectious Diseases
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Author : Tarik Ali Khan
language : en
Publisher:
Release Date : 2012
Delivery Of Vaccines And Therapeutics To Treat Infectious Diseases written by Tarik Ali Khan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Efficient delivery of vaccines and therapeutic agents in vivo is a critical aspect for ensuring a desired immunological or biological response is achieved. This work focuses on developing effective delivery systems for vaccines and therapeutics to achieve biological potency while maintaining patient friendly administration. Traditional vaccines are administered via parenteral injection, which requires skilled personnel for administration and does not elicit strong mucosal immune responses. An alternative approach is to develop an oral vaccine; however, this requires antigens to be protected during transit through the gastrointestinal tract and be transported across specialized intestinal sampling cells called M cells. These M cells are extremely rare, making them an important target for oral vaccines. The protein invasin, from Yersinia psuedotuberculosis, naturally binds [mathematical symbols] integrin, a receptor found exclusively on M cells within the gastrointestinal tract. Therefore, we generated combinatorial libraries of invasin, followed by a directed evolution and high-throughput screening strategy to identify invasin variants with increased affinity towards [mathematical symbols] integrin. This process led to the creation of an invasin variant exhibiting a nine-fold decrease in EC50, which could be used for targeted oral vaccine systems. In order to test for increased vaccine efficacy due to the engineered invasin ligand, we developed a polymeric microparticle delivery system. These microparticles were formulated to encapsulate the model antigen ovalbumin and be decorated with the invasin targeting ligands. To measure physiological trafficking and intestinal retention, novel fluorescent nanocrystals were loaded into particles conjugated to invasin. These nanocrystals served as a contrast agent for in vivo imaging in mice. While these particles were unsuccessful in generating an antibody response toward ovalbumin when administered to mice, a response directed to the targeting ligand itself was observed. These findings provide insights for further optimizing a delivery system for oral vaccination. In addition to developing an oral vaccine delivery system, we created a high concentration therapeutic protein formulation, suitable for low-volume subcutaneous administration. By adding crowding agents, we were able to generate reversible protein nanoclusters with low viscosity. These nanoclusters were found to revert to monomer upon dilution and pharmacokinetic profiles similar to solutions.
Nanocarrier Vaccines
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Author : Vivek P. Chavda
language : en
Publisher: John Wiley & Sons
Release Date : 2024-02-19
Nanocarrier Vaccines written by Vivek P. Chavda and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-19 with Science categories.
NANOCARRIER VACCINES This book details the benefits, restrictions, and types of nanoparticles used in the creation of vaccines for the treatment and prevention of illnesses. In nanomedicine and nano-delivery systems, materials in the nanoscale range are used as diagnostic instruments or to administer therapeutic compounds to particular targeted regions in a controlled manner. By delivering precise medications to specified locations and targets, nanotechnology provides several advantages in treating chronic human illnesses. The use of nanomedicine (including chemotherapeutic medicines, biological agents, immunotherapeutic agents, etc.) in the treatment of various diseases has recently seen many notable applications. This book aims to be a single source material for understanding all the current and novel advancements in the field of nanotechnology. In this groundbreaking book the reader will find: biodegradable and non-biodegradable formulations and properties such as size, shape, charge, inertness, efficacy, morphology, and more; show how different nanoparticles, such as lipid-based, viral vector-based, and metal, uphold very significant properties individually, suggesting applicability in various management tactics; examines how genetic information-carrying entities are becoming the norm for eradicating some diseases; gathers an exhaustive amount of information on routes of administration such as the oral route, mucosal immunity, intramuscular, subcutaneous, and intradermal; explores the legal regulations for nanotechnology-based approaches. Audience Researchers and pharmacy students in biomedical engineering and chemical engineering, biotechnology, as well as pharmaceutical and biopharmaceutical industry engineers working in drug discovery, chemical biology, computational chemistry, medicinal chemistry, and bioinformatics.
Development Of Novel Delivery Technologies For Vaccination Through Oral Administration Of Farmed Salmon
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Author : Zainab Ali
language : en
Publisher:
Release Date : 2019
Development Of Novel Delivery Technologies For Vaccination Through Oral Administration Of Farmed Salmon written by Zainab Ali and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Novel Formulation
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Author : Angkana Tantituvanont
language : en
Publisher:
Release Date : 2003
Novel Formulation written by Angkana Tantituvanont and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with DNA vaccines categories.
Advances In Drug Delivery Systems 6
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Author : James M. Anderson
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Advances In Drug Delivery Systems 6 written by James M. Anderson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Discussions focus on therapeutic efficiency of fatty acylated antiviral antibodies; effect of artificial fatty acylation on protein binding and uptake; and controlled release of proteins from lipid microcylinders. The text then elaborates on mucosal delivery of macromolecules and targeted delivery of diagnostic agents by surface-modified liposomes. The book examines the factors on in vitro micelle stability of adriamycin-block copolymer conjugates; vaginal and reproductive system treatments using a bioadhesive polymer; and control of the disposition profiles of proteins in the kidney via chemical modification. The publication also takes a look at drug delivery using biodegradable microspheres; approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer; and biodegradable microspheres for the delivery of oral vaccines. The selection is a valuable source material for scientists and readers interested in the advances in the systems of drug delivery.
Mucosal Delivery Of Drugs And Biologics In Nanoparticles
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Author : Pavan Muttil
language : en
Publisher: Springer Nature
Release Date : 2020-03-18
Mucosal Delivery Of Drugs And Biologics In Nanoparticles written by Pavan Muttil and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-18 with Medical categories.
Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.